Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis

Endo180, a collagen binding receptor, is highly expressed in a subset of cancer-associated fibroblasts. The authors show, using knockout mice and 3D in vitro assays, that Endo180 depletion impairs tumour fibroblast contractility and viability resulting in reduced tumour growth and metastasis.

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Autores principales:	Ute Jungwirth, Antoinette van Weverwijk, Rachel J. Evans, Liam Jenkins, David Vicente, John Alexander, Qiong Gao, Syed Haider, Marjan Iravani, Clare M. Isacke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d33b1b683b5f48278db9816c890eda30
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spelling	oai:doaj.org-article:d33b1b683b5f48278db9816c890eda302021-12-02T18:06:34ZImpairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis10.1038/s41467-021-23583-12041-1723https://doaj.org/article/d33b1b683b5f48278db9816c890eda302021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23583-1https://doaj.org/toc/2041-1723Endo180, a collagen binding receptor, is highly expressed in a subset of cancer-associated fibroblasts. The authors show, using knockout mice and 3D in vitro assays, that Endo180 depletion impairs tumour fibroblast contractility and viability resulting in reduced tumour growth and metastasis.Ute JungwirthAntoinette van WeverwijkRachel J. EvansLiam JenkinsDavid VicenteJohn AlexanderQiong GaoSyed HaiderMarjan IravaniClare M. IsackeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ute Jungwirth Antoinette van Weverwijk Rachel J. Evans Liam Jenkins David Vicente John Alexander Qiong Gao Syed Haider Marjan Iravani Clare M. Isacke Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
description	Endo180, a collagen binding receptor, is highly expressed in a subset of cancer-associated fibroblasts. The authors show, using knockout mice and 3D in vitro assays, that Endo180 depletion impairs tumour fibroblast contractility and viability resulting in reduced tumour growth and metastasis.
format	article
author	Ute Jungwirth Antoinette van Weverwijk Rachel J. Evans Liam Jenkins David Vicente John Alexander Qiong Gao Syed Haider Marjan Iravani Clare M. Isacke
author_facet	Ute Jungwirth Antoinette van Weverwijk Rachel J. Evans Liam Jenkins David Vicente John Alexander Qiong Gao Syed Haider Marjan Iravani Clare M. Isacke
author_sort	Ute Jungwirth
title	Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
title_short	Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
title_full	Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
title_fullStr	Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
title_full_unstemmed	Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
title_sort	impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d33b1b683b5f48278db9816c890eda30
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Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis

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