Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery

Malik Muhammad Irfan,1,2 Shefaat Ullah Shah,1,2 Ikram Ullah Khan,3 Muhammad Usman Munir,4 Nauman Rahim Khan,1,2 Kifayat Ullah Shah,1 Saif Ur Rehman,5 Muhammad Sohaib,1,2 Hafiz Muhammad Basit,1,2 Saima Mahmood1,2 1Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, D.I. Khan, 29050, K...

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Autores principales:	Irfan MM, Shah SU, Khan IU, Munir MU, Khan NR, Shah KU, Rehman SU, Sohaib M, Basit HM, Mahmood S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	finasteride nanosystem solubility chitosan permeation retention and androgenic alopecia Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d33f0ef4b92447c69884ddbdebad4717
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spelling	oai:doaj.org-article:d33f0ef4b92447c69884ddbdebad47172021-12-02T14:20:03ZPhysicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery1178-2013https://doaj.org/article/d33f0ef4b92447c69884ddbdebad47172021-02-01T00:00:00Zhttps://www.dovepress.com/physicochemical-characterization-of-finasteride-nanosystem-for-enhance-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Malik Muhammad Irfan,1,2 Shefaat Ullah Shah,1,2 Ikram Ullah Khan,3 Muhammad Usman Munir,4 Nauman Rahim Khan,1,2 Kifayat Ullah Shah,1 Saif Ur Rehman,5 Muhammad Sohaib,1,2 Hafiz Muhammad Basit,1,2 Saima Mahmood1,2 1Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, D.I. Khan, 29050, KPK, Pakistan; 2Gomal Centre for Skin/Regenerative Medicine and Drug Delivery Research (GCSRDDR), Faculty of Pharmacy, Gomal University, D.I. Khan, 29050, KPK, Pakistan; 3Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan; 4Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University Sakaka, Aljouf, 72388, Saudi Arabia; 5Department of Pharmacy, Faculty of Medical and Health Sciences, University of Poonch, Rawlakot, AJK, PakistanCorrespondence: Shefaat Ullah ShahDepartment of Pharmaceutics, Faculty of Pharmacy, Gomal University, D.I. Khan, PakistanTel +92-336-514 0 682Email shefaatbu@gmail.comIntroduction: The current work aimed to formulate a novel chitosan-based finasteride nanosystem (FNS-NS) for skin delivery to optimize the drug availability in skin for a longer time and enhance ex vivo performance of finasteride against androgenic alopecia.Methods: Both undecorated and chitosan decorated FNS-NSs were synthesized by a high energy emulsification technique. All the prepared nanosystems were further subjected to physicochemical characterizations like pH, viscosity, encapsulation efficiency, surface morphology and in vitro drug release behavior. The influence of the nanosystem on the drug permeation and retention in rat skin was examined using Franz diffusion cell apparatus.Results: The droplet size of developed nanosystems ranged from 41 to 864 nm with a low polydispersity index. The zeta potential of the nanosystems was between -10 mV and +56 mV. This chitosan decorated nanosystem exhibited controlled drug release, ie about 78– 97% in 24 h. Among all the nanosystems, our chitosan decorated formulation (F5) had low drug permeation (16.35 μg/cm2) and higher drug retention (10.81 μg/cm2).Conclusion: The abovementioned results demonstrate satisfactory in vitro drug release, skin retention profiles and ex vivo performance with chitosan decorated FNS-NS (F5). This optimized formulation could increase drug availability in skin and could become a promising carrier for topical delivery to treat androgenic alopecia.Keywords: finasteride, nanosystem, solubility, chitosan, permeation, retention, androgenic alopeciaIrfan MMShah SUKhan IUMunir MUKhan NRShah KURehman SUSohaib MBasit HMMahmood SDove Medical Pressarticlefinasteridenanosystemsolubilitychitosanpermeationretention and androgenic alopeciaMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 1207-1220 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	finasteride nanosystem solubility chitosan permeation retention and androgenic alopecia Medicine (General) R5-920
spellingShingle	finasteride nanosystem solubility chitosan permeation retention and androgenic alopecia Medicine (General) R5-920 Irfan MM Shah SU Khan IU Munir MU Khan NR Shah KU Rehman SU Sohaib M Basit HM Mahmood S Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery
description	Malik Muhammad Irfan,1,2 Shefaat Ullah Shah,1,2 Ikram Ullah Khan,3 Muhammad Usman Munir,4 Nauman Rahim Khan,1,2 Kifayat Ullah Shah,1 Saif Ur Rehman,5 Muhammad Sohaib,1,2 Hafiz Muhammad Basit,1,2 Saima Mahmood1,2 1Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, D.I. Khan, 29050, KPK, Pakistan; 2Gomal Centre for Skin/Regenerative Medicine and Drug Delivery Research (GCSRDDR), Faculty of Pharmacy, Gomal University, D.I. Khan, 29050, KPK, Pakistan; 3Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan; 4Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University Sakaka, Aljouf, 72388, Saudi Arabia; 5Department of Pharmacy, Faculty of Medical and Health Sciences, University of Poonch, Rawlakot, AJK, PakistanCorrespondence: Shefaat Ullah ShahDepartment of Pharmaceutics, Faculty of Pharmacy, Gomal University, D.I. Khan, PakistanTel +92-336-514 0 682Email shefaatbu@gmail.comIntroduction: The current work aimed to formulate a novel chitosan-based finasteride nanosystem (FNS-NS) for skin delivery to optimize the drug availability in skin for a longer time and enhance ex vivo performance of finasteride against androgenic alopecia.Methods: Both undecorated and chitosan decorated FNS-NSs were synthesized by a high energy emulsification technique. All the prepared nanosystems were further subjected to physicochemical characterizations like pH, viscosity, encapsulation efficiency, surface morphology and in vitro drug release behavior. The influence of the nanosystem on the drug permeation and retention in rat skin was examined using Franz diffusion cell apparatus.Results: The droplet size of developed nanosystems ranged from 41 to 864 nm with a low polydispersity index. The zeta potential of the nanosystems was between -10 mV and +56 mV. This chitosan decorated nanosystem exhibited controlled drug release, ie about 78– 97% in 24 h. Among all the nanosystems, our chitosan decorated formulation (F5) had low drug permeation (16.35 μg/cm2) and higher drug retention (10.81 μg/cm2).Conclusion: The abovementioned results demonstrate satisfactory in vitro drug release, skin retention profiles and ex vivo performance with chitosan decorated FNS-NS (F5). This optimized formulation could increase drug availability in skin and could become a promising carrier for topical delivery to treat androgenic alopecia.Keywords: finasteride, nanosystem, solubility, chitosan, permeation, retention, androgenic alopecia
format	article
author	Irfan MM Shah SU Khan IU Munir MU Khan NR Shah KU Rehman SU Sohaib M Basit HM Mahmood S
author_facet	Irfan MM Shah SU Khan IU Munir MU Khan NR Shah KU Rehman SU Sohaib M Basit HM Mahmood S
author_sort	Irfan MM
title	Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery
title_short	Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery
title_full	Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery
title_fullStr	Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery
title_full_unstemmed	Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery
title_sort	physicochemical characterization of finasteride nanosystem for enhanced topical delivery
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/d33f0ef4b92447c69884ddbdebad4717
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Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery

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