High efficacy of microbial larvicides for malaria vectors control in the city of Yaounde Cameroon following a cluster randomized trial

Abstract The rapid expansion of insecticide resistance and outdoor malaria transmission are affecting the efficacy of current malaria control measures. In urban settings, where malaria transmission is focal and breeding habitats are few, fixed and findable, the addition of anti-larval control measur...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christophe Antonio-Nkondjio, P. Doumbe-Belisse, L. Djamouko-Djonkam, C. S. Ngadjeu, A. Talipouo, E. Kopya, R. Bamou, M. P. Audrey Mayi, N. Sonhafouo-Chiana, D. L. Nkahe, R. Tabue, D. Achu Fosah, Jude D. Bigoga, P. Awono-Ambene, Charles S. Wondji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d3409779e5174404a96bea7c5003a605
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d3409779e5174404a96bea7c5003a605
record_format	dspace
spelling	oai:doaj.org-article:d3409779e5174404a96bea7c5003a6052021-12-02T19:02:32ZHigh efficacy of microbial larvicides for malaria vectors control in the city of Yaounde Cameroon following a cluster randomized trial10.1038/s41598-021-96362-z2045-2322https://doaj.org/article/d3409779e5174404a96bea7c5003a6052021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96362-zhttps://doaj.org/toc/2045-2322Abstract The rapid expansion of insecticide resistance and outdoor malaria transmission are affecting the efficacy of current malaria control measures. In urban settings, where malaria transmission is focal and breeding habitats are few, fixed and findable, the addition of anti-larval control measures could be efficient for malaria vector control. But field evidences for this approach remains scarce. Here we provide findings of a randomized-control larviciding trial conducted in the city of Yaoundé that support the efficacy of this approach. A two arms random control trial design including 26 clusters of 2 to 4 km2 each (13 clusters in the intervention area and 13 in the non-intervention area) was used to assess larviciding efficacy. The microbial larvicide VectoMax combining Bacillus thuringiensis var israelensis (Bti) and Bacillus sphaericus in a single granule was applied every 2 weeks in all standing water collection points. The anopheline density collected using CDC light traps was used as the primary outcome, secondary outcomes included the entomological inoculation rate, breeding habitats with anopheline larvae, and larval density. Baseline entomological data collection was conducted for 17 months from March 2017 to July 2018 and the intervention lasted 26 months from September 2018 to November 2020. The intervention was associated with a reduction of 68% of adult anopheline biting density and of 79% of the entomological inoculation rate (OR 0.21; 95% CI 0.14–0.30, P < 0.0001). A reduction of 68.27% was recorded for indoor biting anophelines and 57.74% for outdoor biting anophelines. No impact on the composition of anopheline species was recorded. A reduction of over 35% of adult Culex biting densities was recorded. The study indicated high efficacy of larviciding for reducing malaria transmission intensity in the city of Yaoundé. Larviciding could be part of an integrated control approach for controlling malaria vectors and other mosquito species in the urban environment.Christophe Antonio-NkondjioP. Doumbe-BelisseL. Djamouko-DjonkamC. S. NgadjeuA. TalipouoE. KopyaR. BamouM. P. Audrey MayiN. Sonhafouo-ChianaD. L. NkaheR. TabueD. Achu FosahJude D. BigogaP. Awono-AmbeneCharles S. WondjiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christophe Antonio-Nkondjio P. Doumbe-Belisse L. Djamouko-Djonkam C. S. Ngadjeu A. Talipouo E. Kopya R. Bamou M. P. Audrey Mayi N. Sonhafouo-Chiana D. L. Nkahe R. Tabue D. Achu Fosah Jude D. Bigoga P. Awono-Ambene Charles S. Wondji High efficacy of microbial larvicides for malaria vectors control in the city of Yaounde Cameroon following a cluster randomized trial
description	Abstract The rapid expansion of insecticide resistance and outdoor malaria transmission are affecting the efficacy of current malaria control measures. In urban settings, where malaria transmission is focal and breeding habitats are few, fixed and findable, the addition of anti-larval control measures could be efficient for malaria vector control. But field evidences for this approach remains scarce. Here we provide findings of a randomized-control larviciding trial conducted in the city of Yaoundé that support the efficacy of this approach. A two arms random control trial design including 26 clusters of 2 to 4 km2 each (13 clusters in the intervention area and 13 in the non-intervention area) was used to assess larviciding efficacy. The microbial larvicide VectoMax combining Bacillus thuringiensis var israelensis (Bti) and Bacillus sphaericus in a single granule was applied every 2 weeks in all standing water collection points. The anopheline density collected using CDC light traps was used as the primary outcome, secondary outcomes included the entomological inoculation rate, breeding habitats with anopheline larvae, and larval density. Baseline entomological data collection was conducted for 17 months from March 2017 to July 2018 and the intervention lasted 26 months from September 2018 to November 2020. The intervention was associated with a reduction of 68% of adult anopheline biting density and of 79% of the entomological inoculation rate (OR 0.21; 95% CI 0.14–0.30, P < 0.0001). A reduction of 68.27% was recorded for indoor biting anophelines and 57.74% for outdoor biting anophelines. No impact on the composition of anopheline species was recorded. A reduction of over 35% of adult Culex biting densities was recorded. The study indicated high efficacy of larviciding for reducing malaria transmission intensity in the city of Yaoundé. Larviciding could be part of an integrated control approach for controlling malaria vectors and other mosquito species in the urban environment.
format	article
author	Christophe Antonio-Nkondjio P. Doumbe-Belisse L. Djamouko-Djonkam C. S. Ngadjeu A. Talipouo E. Kopya R. Bamou M. P. Audrey Mayi N. Sonhafouo-Chiana D. L. Nkahe R. Tabue D. Achu Fosah Jude D. Bigoga P. Awono-Ambene Charles S. Wondji
author_facet	Christophe Antonio-Nkondjio P. Doumbe-Belisse L. Djamouko-Djonkam C. S. Ngadjeu A. Talipouo E. Kopya R. Bamou M. P. Audrey Mayi N. Sonhafouo-Chiana D. L. Nkahe R. Tabue D. Achu Fosah Jude D. Bigoga P. Awono-Ambene Charles S. Wondji
author_sort	Christophe Antonio-Nkondjio
title	High efficacy of microbial larvicides for malaria vectors control in the city of Yaounde Cameroon following a cluster randomized trial
title_short	High efficacy of microbial larvicides for malaria vectors control in the city of Yaounde Cameroon following a cluster randomized trial
title_full	High efficacy of microbial larvicides for malaria vectors control in the city of Yaounde Cameroon following a cluster randomized trial
title_fullStr	High efficacy of microbial larvicides for malaria vectors control in the city of Yaounde Cameroon following a cluster randomized trial
title_full_unstemmed	High efficacy of microbial larvicides for malaria vectors control in the city of Yaounde Cameroon following a cluster randomized trial
title_sort	high efficacy of microbial larvicides for malaria vectors control in the city of yaounde cameroon following a cluster randomized trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d3409779e5174404a96bea7c5003a605
work_keys_str_mv	AT christopheantonionkondjio highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial AT pdoumbebelisse highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial AT ldjamoukodjonkam highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial AT csngadjeu highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial AT atalipouo highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial AT ekopya highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial AT rbamou highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial AT mpaudreymayi highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial AT nsonhafouochiana highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial AT dlnkahe highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial AT rtabue highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial AT dachufosah highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial AT judedbigoga highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial AT pawonoambene highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial AT charlesswondji highefficacyofmicrobiallarvicidesformalariavectorscontrolinthecityofyaoundecameroonfollowingaclusterrandomizedtrial
_version_	1718377296476241920

High efficacy of microbial larvicides for malaria vectors control in the city of Yaounde Cameroon following a cluster randomized trial

Ejemplares similares