Structural determinants and regulation of spontaneous activity in GABAA receptors

GABAA receptors (GABAARs) cause inhibition in the brain by functioning as heteropentamers formed from multiple subunit types. Here, the authors demonstrate that receptors incorporating β3 subunits can spontaneously gate, which is modulated by protein kinases and neurosteroids to affect tonic inhibit...

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Autores principales:	Craig A. Sexton, Reka Penzinger, Martin Mortensen, Damian P. Bright, Trevor G. Smart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d345dc169b86449ab9fb68e8dd692c86
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spelling	oai:doaj.org-article:d345dc169b86449ab9fb68e8dd692c862021-12-02T15:16:10ZStructural determinants and regulation of spontaneous activity in GABAA receptors10.1038/s41467-021-25633-02041-1723https://doaj.org/article/d345dc169b86449ab9fb68e8dd692c862021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25633-0https://doaj.org/toc/2041-1723GABAA receptors (GABAARs) cause inhibition in the brain by functioning as heteropentamers formed from multiple subunit types. Here, the authors demonstrate that receptors incorporating β3 subunits can spontaneously gate, which is modulated by protein kinases and neurosteroids to affect tonic inhibition.Craig A. SextonReka PenzingerMartin MortensenDamian P. BrightTrevor G. SmartNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Craig A. Sexton Reka Penzinger Martin Mortensen Damian P. Bright Trevor G. Smart Structural determinants and regulation of spontaneous activity in GABAA receptors
description	GABAA receptors (GABAARs) cause inhibition in the brain by functioning as heteropentamers formed from multiple subunit types. Here, the authors demonstrate that receptors incorporating β3 subunits can spontaneously gate, which is modulated by protein kinases and neurosteroids to affect tonic inhibition.
format	article
author	Craig A. Sexton Reka Penzinger Martin Mortensen Damian P. Bright Trevor G. Smart
author_facet	Craig A. Sexton Reka Penzinger Martin Mortensen Damian P. Bright Trevor G. Smart
author_sort	Craig A. Sexton
title	Structural determinants and regulation of spontaneous activity in GABAA receptors
title_short	Structural determinants and regulation of spontaneous activity in GABAA receptors
title_full	Structural determinants and regulation of spontaneous activity in GABAA receptors
title_fullStr	Structural determinants and regulation of spontaneous activity in GABAA receptors
title_full_unstemmed	Structural determinants and regulation of spontaneous activity in GABAA receptors
title_sort	structural determinants and regulation of spontaneous activity in gabaa receptors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d345dc169b86449ab9fb68e8dd692c86
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Structural determinants and regulation of spontaneous activity in GABAA receptors

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