Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles

Late-stage C(sp3)-H bond functionalization of N-heterocycles with broad substrate scope remains a challenge and of particular significance to modern chemical synthesis and pharmaceutical chemistry. Here the authors show copper-catalysed late-stage C(sp3)-H functionalizaion of N-heterocycles using co...

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Autores principales:	Zhe Chang, Jialin Huang, Si Wang, Geshuyi Chen, Heng Zhao, Rui Wang, Depeng Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d346beb58e7742acacbffd577043a344
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spelling	oai:doaj.org-article:d346beb58e7742acacbffd577043a3442021-12-02T18:36:59ZCopper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles10.1038/s41467-021-24671-y2041-1723https://doaj.org/article/d346beb58e7742acacbffd577043a3442021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24671-yhttps://doaj.org/toc/2041-1723Late-stage C(sp3)-H bond functionalization of N-heterocycles with broad substrate scope remains a challenge and of particular significance to modern chemical synthesis and pharmaceutical chemistry. Here the authors show copper-catalysed late-stage C(sp3)-H functionalizaion of N-heterocycles using commercially available catalysts under mild reaction conditions.Zhe ChangJialin HuangSi WangGeshuyi ChenHeng ZhaoRui WangDepeng ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhe Chang Jialin Huang Si Wang Geshuyi Chen Heng Zhao Rui Wang Depeng Zhao Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles
description	Late-stage C(sp3)-H bond functionalization of N-heterocycles with broad substrate scope remains a challenge and of particular significance to modern chemical synthesis and pharmaceutical chemistry. Here the authors show copper-catalysed late-stage C(sp3)-H functionalizaion of N-heterocycles using commercially available catalysts under mild reaction conditions.
format	article
author	Zhe Chang Jialin Huang Si Wang Geshuyi Chen Heng Zhao Rui Wang Depeng Zhao
author_facet	Zhe Chang Jialin Huang Si Wang Geshuyi Chen Heng Zhao Rui Wang Depeng Zhao
author_sort	Zhe Chang
title	Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles
title_short	Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles
title_full	Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles
title_fullStr	Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles
title_full_unstemmed	Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles
title_sort	copper catalyzed late-stage c(sp3)-h functionalization of nitrogen heterocycles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d346beb58e7742acacbffd577043a344
work_keys_str_mv	AT zhechang coppercatalyzedlatestagecsp3hfunctionalizationofnitrogenheterocycles AT jialinhuang coppercatalyzedlatestagecsp3hfunctionalizationofnitrogenheterocycles AT siwang coppercatalyzedlatestagecsp3hfunctionalizationofnitrogenheterocycles AT geshuyichen coppercatalyzedlatestagecsp3hfunctionalizationofnitrogenheterocycles AT hengzhao coppercatalyzedlatestagecsp3hfunctionalizationofnitrogenheterocycles AT ruiwang coppercatalyzedlatestagecsp3hfunctionalizationofnitrogenheterocycles AT depengzhao coppercatalyzedlatestagecsp3hfunctionalizationofnitrogenheterocycles
_version_	1718377889504690176

Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles

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