Vocal aging and adductor spasmodic dysphonia: Response to botulinum toxin injection

Michael P Cannito, Joel C Kahane, Lesya ChornaSchool of Audiology and Speech-Language Pathology, The University of Memphis, Memphis, TN, USAAbstract: Aging of the larynx is characterized by involutional changes which alter its biomechanical and neural properties and create a biological environment t...

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Autores principales:	Michael P Cannito, Joel C Kahane, Lesya Chorna
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/d3477d57bf054982b7caad22fc6161ab
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spelling	oai:doaj.org-article:d3477d57bf054982b7caad22fc6161ab2021-12-02T06:36:08ZVocal aging and adductor spasmodic dysphonia: Response to botulinum toxin injection1178-1998https://doaj.org/article/d3477d57bf054982b7caad22fc6161ab2008-03-01T00:00:00Zhttps://www.dovepress.com/vocal-aging-and-adductor-spasmodic-dysphonia-response-to-botulinum-tox-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Michael P Cannito, Joel C Kahane, Lesya ChornaSchool of Audiology and Speech-Language Pathology, The University of Memphis, Memphis, TN, USAAbstract: Aging of the larynx is characterized by involutional changes which alter its biomechanical and neural properties and create a biological environment that is different from younger counterparts. Illustrative anatomical examples are presented. This natural, non-disease process appears to set conditions which may influence the effectiveness of botulinum toxin injection and our expectations for its success. Adductor spasmodic dysphonia, a type of laryngeal dystonia, is typically treated using botulinum toxin injections of the vocal folds in order to suppress adductory muscle spasms which are disruptive to production of speech and voice. A few studies have suggested diminished response to treatment in older patients with adductor spasmodic dysphonia. This retrospective study provides a reanalysis of existing pre-to-post treatment data as function of age. Perceptual judgments of speech produced by 42 patients with ADSD were made by two panels of professional listeners with expertise in voice or fluency of speech. Results demonstrate a markedly reduced positive response to botulinum toxin treatment in the older patients. Perceptual findings are further elucidated by means of acoustic spectrography. Literature on vocal aging is reviewed to provide a specific set of biological mechanisms that best account for the observed interaction of botulinum toxin treatment with advancing age.Keywords: vocal aging, adductor spasmodic dysphonia, botulinum toxin, voice quality, speech fluencyMichael P CannitoJoel C KahaneLesya ChornaDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 3, Pp 131-151 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Michael P Cannito Joel C Kahane Lesya Chorna Vocal aging and adductor spasmodic dysphonia: Response to botulinum toxin injection
description	Michael P Cannito, Joel C Kahane, Lesya ChornaSchool of Audiology and Speech-Language Pathology, The University of Memphis, Memphis, TN, USAAbstract: Aging of the larynx is characterized by involutional changes which alter its biomechanical and neural properties and create a biological environment that is different from younger counterparts. Illustrative anatomical examples are presented. This natural, non-disease process appears to set conditions which may influence the effectiveness of botulinum toxin injection and our expectations for its success. Adductor spasmodic dysphonia, a type of laryngeal dystonia, is typically treated using botulinum toxin injections of the vocal folds in order to suppress adductory muscle spasms which are disruptive to production of speech and voice. A few studies have suggested diminished response to treatment in older patients with adductor spasmodic dysphonia. This retrospective study provides a reanalysis of existing pre-to-post treatment data as function of age. Perceptual judgments of speech produced by 42 patients with ADSD were made by two panels of professional listeners with expertise in voice or fluency of speech. Results demonstrate a markedly reduced positive response to botulinum toxin treatment in the older patients. Perceptual findings are further elucidated by means of acoustic spectrography. Literature on vocal aging is reviewed to provide a specific set of biological mechanisms that best account for the observed interaction of botulinum toxin treatment with advancing age.Keywords: vocal aging, adductor spasmodic dysphonia, botulinum toxin, voice quality, speech fluency
format	article
author	Michael P Cannito Joel C Kahane Lesya Chorna
author_facet	Michael P Cannito Joel C Kahane Lesya Chorna
author_sort	Michael P Cannito
title	Vocal aging and adductor spasmodic dysphonia: Response to botulinum toxin injection
title_short	Vocal aging and adductor spasmodic dysphonia: Response to botulinum toxin injection
title_full	Vocal aging and adductor spasmodic dysphonia: Response to botulinum toxin injection
title_fullStr	Vocal aging and adductor spasmodic dysphonia: Response to botulinum toxin injection
title_full_unstemmed	Vocal aging and adductor spasmodic dysphonia: Response to botulinum toxin injection
title_sort	vocal aging and adductor spasmodic dysphonia: response to botulinum toxin injection
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/d3477d57bf054982b7caad22fc6161ab
work_keys_str_mv	AT michaelpcannito vocalagingandadductorspasmodicdysphoniaresponsetobotulinumtoxininjection AT joelckahane vocalagingandadductorspasmodicdysphoniaresponsetobotulinumtoxininjection AT lesyachorna vocalagingandadductorspasmodicdysphoniaresponsetobotulinumtoxininjection
_version_	1718399839935397888

Vocal aging and adductor spasmodic dysphonia: Response to botulinum toxin injection

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