STDP and the distribution of preferred phases in the whisker system.

Rats and mice use their whiskers to probe the environment. By rhythmically swiping their whiskers back and forth they can detect the existence of an object, locate it, and identify its texture. Localization can be accomplished by inferring the whisker's position. Rhythmic neurons that track the...

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Autores principales:	Nimrod Sherf, Maoz Shamir
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d34935f35ae9411dbd2613d4b597c257
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spelling	oai:doaj.org-article:d34935f35ae9411dbd2613d4b597c2572021-12-02T19:57:46ZSTDP and the distribution of preferred phases in the whisker system.1553-734X1553-735810.1371/journal.pcbi.1009353https://doaj.org/article/d34935f35ae9411dbd2613d4b597c2572021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009353https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Rats and mice use their whiskers to probe the environment. By rhythmically swiping their whiskers back and forth they can detect the existence of an object, locate it, and identify its texture. Localization can be accomplished by inferring the whisker's position. Rhythmic neurons that track the phase of the whisking cycle encode information about the azimuthal location of the whisker. These neurons are characterized by preferred phases of firing that are narrowly distributed. Consequently, pooling the rhythmic signal from several upstream neurons is expected to result in a much narrower distribution of preferred phases in the downstream population, which however has not been observed empirically. Here, we show how spike timing dependent plasticity (STDP) can provide a solution to this conundrum. We investigated the effect of STDP on the utility of a neural population to transmit rhythmic information downstream using the framework of a modeling study. We found that under a wide range of parameters, STDP facilitated the transfer of rhythmic information despite the fact that all the synaptic weights remained dynamic. As a result, the preferred phase of the downstream neuron was not fixed, but rather drifted in time at a drift velocity that depended on the preferred phase, thus inducing a distribution of preferred phases. We further analyzed how the STDP rule governs the distribution of preferred phases in the downstream population. This link between the STDP rule and the distribution of preferred phases constitutes a natural test for our theory.Nimrod SherfMaoz ShamirPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 9, p e1009353 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Nimrod Sherf Maoz Shamir STDP and the distribution of preferred phases in the whisker system.
description	Rats and mice use their whiskers to probe the environment. By rhythmically swiping their whiskers back and forth they can detect the existence of an object, locate it, and identify its texture. Localization can be accomplished by inferring the whisker's position. Rhythmic neurons that track the phase of the whisking cycle encode information about the azimuthal location of the whisker. These neurons are characterized by preferred phases of firing that are narrowly distributed. Consequently, pooling the rhythmic signal from several upstream neurons is expected to result in a much narrower distribution of preferred phases in the downstream population, which however has not been observed empirically. Here, we show how spike timing dependent plasticity (STDP) can provide a solution to this conundrum. We investigated the effect of STDP on the utility of a neural population to transmit rhythmic information downstream using the framework of a modeling study. We found that under a wide range of parameters, STDP facilitated the transfer of rhythmic information despite the fact that all the synaptic weights remained dynamic. As a result, the preferred phase of the downstream neuron was not fixed, but rather drifted in time at a drift velocity that depended on the preferred phase, thus inducing a distribution of preferred phases. We further analyzed how the STDP rule governs the distribution of preferred phases in the downstream population. This link between the STDP rule and the distribution of preferred phases constitutes a natural test for our theory.
format	article
author	Nimrod Sherf Maoz Shamir
author_facet	Nimrod Sherf Maoz Shamir
author_sort	Nimrod Sherf
title	STDP and the distribution of preferred phases in the whisker system.
title_short	STDP and the distribution of preferred phases in the whisker system.
title_full	STDP and the distribution of preferred phases in the whisker system.
title_fullStr	STDP and the distribution of preferred phases in the whisker system.
title_full_unstemmed	STDP and the distribution of preferred phases in the whisker system.
title_sort	stdp and the distribution of preferred phases in the whisker system.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d34935f35ae9411dbd2613d4b597c257
work_keys_str_mv	AT nimrodsherf stdpandthedistributionofpreferredphasesinthewhiskersystem AT maozshamir stdpandthedistributionofpreferredphasesinthewhiskersystem
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STDP and the distribution of preferred phases in the whisker system.

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