BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation

BTG2 promotes mRNA poly(A) tail shortening and regulates cellular differentiation. Here, Stupfler et al. show that the BTG2 APRO domain interacts with PABPC1 RRM1, allowing the former to recruit and stimulate the poly(A) tail shortening activity of CAF1 deadenylase and to control cell proliferation.

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Autores principales:	Benjamin Stupfler, Catherine Birck, Bertrand Séraphin, Fabienne Mauxion
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d3496cb77c9e4475a194e5471d760c2a
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spelling	oai:doaj.org-article:d3496cb77c9e4475a194e5471d760c2a2021-12-02T17:33:09ZBTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation10.1038/ncomms108112041-1723https://doaj.org/article/d3496cb77c9e4475a194e5471d760c2a2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10811https://doaj.org/toc/2041-1723BTG2 promotes mRNA poly(A) tail shortening and regulates cellular differentiation. Here, Stupfler et al. show that the BTG2 APRO domain interacts with PABPC1 RRM1, allowing the former to recruit and stimulate the poly(A) tail shortening activity of CAF1 deadenylase and to control cell proliferation.Benjamin StupflerCatherine BirckBertrand SéraphinFabienne MauxionNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin Stupfler Catherine Birck Bertrand Séraphin Fabienne Mauxion BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation
description	BTG2 promotes mRNA poly(A) tail shortening and regulates cellular differentiation. Here, Stupfler et al. show that the BTG2 APRO domain interacts with PABPC1 RRM1, allowing the former to recruit and stimulate the poly(A) tail shortening activity of CAF1 deadenylase and to control cell proliferation.
format	article
author	Benjamin Stupfler Catherine Birck Bertrand Séraphin Fabienne Mauxion
author_facet	Benjamin Stupfler Catherine Birck Bertrand Séraphin Fabienne Mauxion
author_sort	Benjamin Stupfler
title	BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation
title_short	BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation
title_full	BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation
title_fullStr	BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation
title_full_unstemmed	BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation
title_sort	btg2 bridges pabpc1 rna-binding domains and caf1 deadenylase to control cell proliferation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d3496cb77c9e4475a194e5471d760c2a
work_keys_str_mv	AT benjaminstupfler btg2bridgespabpc1rnabindingdomainsandcaf1deadenylasetocontrolcellproliferation AT catherinebirck btg2bridgespabpc1rnabindingdomainsandcaf1deadenylasetocontrolcellproliferation AT bertrandseraphin btg2bridgespabpc1rnabindingdomainsandcaf1deadenylasetocontrolcellproliferation AT fabiennemauxion btg2bridgespabpc1rnabindingdomainsandcaf1deadenylasetocontrolcellproliferation
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BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation

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