Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers

Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers

Human endogenous retroviruses (HERV) normally remain quiescent, but can be reactivated by malignant transformation. Here the authors find, via HERV peptide library testing and tetramer validation, more profound HERV transcription and associated T cell recognition in myeloid cancer patients to implic...

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Autores principales: Sunil Kumar Saini, Andreas Due Ørskov, Anne-Mette Bjerregaard, Ashwin Unnikrishnan, Staffan Holmberg-Thydén, Annie Borch, Kathrine Valentini Jensen, Govardhan Anande, Amalie Kai Bentzen, Andrea Marion Marquard, Tripti Tamhane, Marianne Bach Treppendahl, Anne Ortved Gang, Inge Høgh Dufva, Zoltan Szallasi, Nicola Ternette, Anders Gorm Pedersen, Aron Charles Eklund, John Pimanda, Kirsten Grønbæk, Sine Reker Hadrup
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/d34a194f6b844353a08c2553d7fdeaee
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Sumario:Human endogenous retroviruses (HERV) normally remain quiescent, but can be reactivated by malignant transformation. Here the authors find, via HERV peptide library testing and tetramer validation, more profound HERV transcription and associated T cell recognition in myeloid cancer patients to implicate HERVs as potential therapeutic targets.

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