Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers
Human endogenous retroviruses (HERV) normally remain quiescent, but can be reactivated by malignant transformation. Here the authors find, via HERV peptide library testing and tetramer validation, more profound HERV transcription and associated T cell recognition in myeloid cancer patients to implic...
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Nature Portfolio
2020
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oai:doaj.org-article:d34a194f6b844353a08c2553d7fdeaee2021-12-02T16:50:00ZHuman endogenous retroviruses form a reservoir of T cell targets in hematological cancers10.1038/s41467-020-19464-82041-1723https://doaj.org/article/d34a194f6b844353a08c2553d7fdeaee2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19464-8https://doaj.org/toc/2041-1723Human endogenous retroviruses (HERV) normally remain quiescent, but can be reactivated by malignant transformation. Here the authors find, via HERV peptide library testing and tetramer validation, more profound HERV transcription and associated T cell recognition in myeloid cancer patients to implicate HERVs as potential therapeutic targets.Sunil Kumar SainiAndreas Due ØrskovAnne-Mette BjerregaardAshwin UnnikrishnanStaffan Holmberg-ThydénAnnie BorchKathrine Valentini JensenGovardhan AnandeAmalie Kai BentzenAndrea Marion MarquardTripti TamhaneMarianne Bach TreppendahlAnne Ortved GangInge Høgh DufvaZoltan SzallasiNicola TernetteAnders Gorm PedersenAron Charles EklundJohn PimandaKirsten GrønbækSine Reker HadrupNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Sunil Kumar Saini Andreas Due Ørskov Anne-Mette Bjerregaard Ashwin Unnikrishnan Staffan Holmberg-Thydén Annie Borch Kathrine Valentini Jensen Govardhan Anande Amalie Kai Bentzen Andrea Marion Marquard Tripti Tamhane Marianne Bach Treppendahl Anne Ortved Gang Inge Høgh Dufva Zoltan Szallasi Nicola Ternette Anders Gorm Pedersen Aron Charles Eklund John Pimanda Kirsten Grønbæk Sine Reker Hadrup Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers |
| description |
Human endogenous retroviruses (HERV) normally remain quiescent, but can be reactivated by malignant transformation. Here the authors find, via HERV peptide library testing and tetramer validation, more profound HERV transcription and associated T cell recognition in myeloid cancer patients to implicate HERVs as potential therapeutic targets. |
| format |
article |
| author |
Sunil Kumar Saini Andreas Due Ørskov Anne-Mette Bjerregaard Ashwin Unnikrishnan Staffan Holmberg-Thydén Annie Borch Kathrine Valentini Jensen Govardhan Anande Amalie Kai Bentzen Andrea Marion Marquard Tripti Tamhane Marianne Bach Treppendahl Anne Ortved Gang Inge Høgh Dufva Zoltan Szallasi Nicola Ternette Anders Gorm Pedersen Aron Charles Eklund John Pimanda Kirsten Grønbæk Sine Reker Hadrup |
| author_facet |
Sunil Kumar Saini Andreas Due Ørskov Anne-Mette Bjerregaard Ashwin Unnikrishnan Staffan Holmberg-Thydén Annie Borch Kathrine Valentini Jensen Govardhan Anande Amalie Kai Bentzen Andrea Marion Marquard Tripti Tamhane Marianne Bach Treppendahl Anne Ortved Gang Inge Høgh Dufva Zoltan Szallasi Nicola Ternette Anders Gorm Pedersen Aron Charles Eklund John Pimanda Kirsten Grønbæk Sine Reker Hadrup |
| author_sort |
Sunil Kumar Saini |
| title |
Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers |
| title_short |
Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers |
| title_full |
Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers |
| title_fullStr |
Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers |
| title_full_unstemmed |
Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers |
| title_sort |
human endogenous retroviruses form a reservoir of t cell targets in hematological cancers |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/d34a194f6b844353a08c2553d7fdeaee |
| work_keys_str_mv |
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1718383186408374272 |