Functional genomic analysis identifies miRNA repertoire regulating C. elegans oocyte development

Biogenesis and function of miRNAs in somatic cells is well characterized, but their role in the germline has not been established. Here the authors identify and characterize Drosha independent and dependent miRNAs during C. elegans oogenesis, revealing their roles in meiotic progression and oocyte d...

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Bibliographic Details
Main Authors: Amanda L. Minogue, Michael R. Tackett, Elnaz Atabakhsh, Genesis Tejada, Swathi Arur
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/d34af9cea2764ebaa8f0e7196aa96005
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Summary:Biogenesis and function of miRNAs in somatic cells is well characterized, but their role in the germline has not been established. Here the authors identify and characterize Drosha independent and dependent miRNAs during C. elegans oogenesis, revealing their roles in meiotic progression and oocyte development.