Functional genomic analysis identifies miRNA repertoire regulating C. elegans oocyte development

Biogenesis and function of miRNAs in somatic cells is well characterized, but their role in the germline has not been established. Here the authors identify and characterize Drosha independent and dependent miRNAs during C. elegans oogenesis, revealing their roles in meiotic progression and oocyte d...

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Autores principales: Amanda L. Minogue, Michael R. Tackett, Elnaz Atabakhsh, Genesis Tejada, Swathi Arur
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d34af9cea2764ebaa8f0e7196aa96005
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Sumario:Biogenesis and function of miRNAs in somatic cells is well characterized, but their role in the germline has not been established. Here the authors identify and characterize Drosha independent and dependent miRNAs during C. elegans oogenesis, revealing their roles in meiotic progression and oocyte development.