Conformational changes in intact dengue virus reveal serotype-specific expansion

Conformational changes in intact dengue virus reveal serotype-specific expansion

Temperature differences between mosquitoes and humans trigger structural changes in dengue virus 2 (DENV2) particles, but not in other DENV serotypes. Here, using HDXMS, the authors describe serotype-specific expansion of intact viral particles of DENV1 and DENV2 at 28 °C (mosquitoes), 37 °C (humans...

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Autores principales: Xin-Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, Nirmalya Bag, Kamal Kant Sharma, Melissa Wirawan, Thorsten Wohland, Shee-Mei Lok, Ganesh S. Anand
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/d34d5ae0dd4f44a88618484220093aef
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spelling oai:doaj.org-article:d34d5ae0dd4f44a88618484220093aef2021-12-02T15:38:59ZConformational changes in intact dengue virus reveal serotype-specific expansion10.1038/ncomms143392041-1723https://doaj.org/article/d34d5ae0dd4f44a88618484220093aef2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14339https://doaj.org/toc/2041-1723Temperature differences between mosquitoes and humans trigger structural changes in dengue virus 2 (DENV2) particles, but not in other DENV serotypes. Here, using HDXMS, the authors describe serotype-specific expansion of intact viral particles of DENV1 and DENV2 at 28 °C (mosquitoes), 37 °C (humans) and 40 °C (fever).Xin-Xiang LimArun ChandramohanXin Ying Elisa LimNirmalya BagKamal Kant SharmaMelissa WirawanThorsten WohlandShee-Mei LokGanesh S. AnandNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xin-Xiang Lim
Arun Chandramohan
Xin Ying Elisa Lim
Nirmalya Bag
Kamal Kant Sharma
Melissa Wirawan
Thorsten Wohland
Shee-Mei Lok
Ganesh S. Anand
Conformational changes in intact dengue virus reveal serotype-specific expansion
description Temperature differences between mosquitoes and humans trigger structural changes in dengue virus 2 (DENV2) particles, but not in other DENV serotypes. Here, using HDXMS, the authors describe serotype-specific expansion of intact viral particles of DENV1 and DENV2 at 28 °C (mosquitoes), 37 °C (humans) and 40 °C (fever).
format article
author Xin-Xiang Lim
Arun Chandramohan
Xin Ying Elisa Lim
Nirmalya Bag
Kamal Kant Sharma
Melissa Wirawan
Thorsten Wohland
Shee-Mei Lok
Ganesh S. Anand
author_facet Xin-Xiang Lim
Arun Chandramohan
Xin Ying Elisa Lim
Nirmalya Bag
Kamal Kant Sharma
Melissa Wirawan
Thorsten Wohland
Shee-Mei Lok
Ganesh S. Anand
author_sort Xin-Xiang Lim
title Conformational changes in intact dengue virus reveal serotype-specific expansion
title_short Conformational changes in intact dengue virus reveal serotype-specific expansion
title_full Conformational changes in intact dengue virus reveal serotype-specific expansion
title_fullStr Conformational changes in intact dengue virus reveal serotype-specific expansion
title_full_unstemmed Conformational changes in intact dengue virus reveal serotype-specific expansion
title_sort conformational changes in intact dengue virus reveal serotype-specific expansion
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/d34d5ae0dd4f44a88618484220093aef
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AT arunchandramohan conformationalchangesinintactdenguevirusrevealserotypespecificexpansion
AT xinyingelisalim conformationalchangesinintactdenguevirusrevealserotypespecificexpansion
AT nirmalyabag conformationalchangesinintactdenguevirusrevealserotypespecificexpansion
AT kamalkantsharma conformationalchangesinintactdenguevirusrevealserotypespecificexpansion
AT melissawirawan conformationalchangesinintactdenguevirusrevealserotypespecificexpansion
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AT ganeshsanand conformationalchangesinintactdenguevirusrevealserotypespecificexpansion
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