Phosphoprotein Phosphatase 1 but Not 2A Activity Modulates Coupled-Clock Mechanisms to Impact on Intrinsic Automaticity of Sinoatrial Nodal Pacemaker Cells

QR Code

Phosphoprotein Phosphatase 1 but Not 2A Activity Modulates Coupled-Clock Mechanisms to Impact on Intrinsic Automaticity of Sinoatrial Nodal Pacemaker Cells

Spontaneous AP (action potential) firing of sinoatrial nodal cells (SANC) is critically dependent on protein kinase A (PKA) and Ca<sup>2+</sup>/calmodulin-dependent protein kinase II (CaMKII)-dependent protein phosphorylation, which are required for the generation of spontaneous, diastol...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Syevda Tagirova Sirenko, Ihor Zahanich, Yue Li, Yevgeniya O. Lukyanenko, Alexey E. Lyashkov, Bruce D. Ziman, Kirill V. Tarasov, Antoine Younes, Daniel R. Riordon, Yelena S. Tarasova, Dongmei Yang, Tatiana M. Vinogradova, Victor A. Maltsev, Edward G. Lakatta
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	sinoatrial node cells local Ca<sup>2+</sup> releases phosphoprotein phosphatase endogenous phosphatase inhibitors calyculin A okadaic acid Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/d34e3e9a556b4610af29e09b6ffdc8e6
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Novel Antioxidants and <i>α</i>-Glycosidase and Protein Tyrosine Phosphatase 1B Inhibitors from an Endophytic Fungus <i>Penicillium brefeldianum</i> F4a
par: Yan Bai, et autres
Publié: (2021)

Study of Sinoatrial Nodal Artery Dominance in Brazilian Human Hearts
par: Bezerra,Frank Silva, et autres
Publié: (2008)

Comparison of Three CD3-Specific Separation Methods Leading to Labeled and Label-Free T Cells
par: Ronald Weiss, et autres
Publié: (2021)

Electromagnetic Interference Shielding of 2D Transition Metal Carbide (MXene)/Metal Ion Composites
par: Xuefeng Xia, et autres
Publié: (2021)

A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis
par: James Adams, et autres
Publié: (2021)

Variants of Oxidized Regenerated Cellulose and Their Distinct Effects on Neuronal Tissue
par: Joshua Kleine, et autres
Publié: (2021)

The Lipid A 1-Phosphatase, LpxE, Functionally Connects Multiple Layers of Bacterial Envelope Biogenesis
par: Jinshi Zhao, et autres
Publié: (2019)

Impact of different levels of superphosphate using arbuscular mycorrhizal fungi and Pseudomonasfluorescens on Chrysanthemum indicum L
par: Prasad,K, et autres
Publié: (2012)

Ca<sup>2+</sup>/Sr<sup>2+</sup> Selectivity in Calcium-Sensing Receptor (CaSR): Implications for Strontium’s Anti-Osteoporosis Effect
par: Diana Cheshmedzhieva, et autres
Publié: (2021)

Recombinant BCG-Prime and DNA-Boost Immunization Confers Mice with Enhanced Protection against <i>Mycobacterium kansasii</i>
par: Shihoko Komine-Aizawa, et autres
Publié: (2021)

Effects of Citrate on inhibitory role of Iron in Bacillus Cereus growth and metabolism
par: N Kalantari, et autres
Publié: (1999)

Molecular Imaging in Primary Staging of Prostate Cancer Patients: Current Aspects and Future Trends
par: Reyhaneh Manafi-Farid, et autres
Publié: (2021)

Electrochemical and Fluorescent Properties of Crown Ether Functionalized Graphene Quantum Dots for Potassium and Sodium Ions Detection
par: Daniela Iannazzo, et autres
Publié: (2021)

Separation of <sup>44</sup>Sc from <sup>44</sup>Ti in the Context of A Generator System for Radiopharmaceutical Purposes with the Example of [<sup>44</sup>Sc]Sc-PSMA-617 and [<sup>44</sup>Sc]Sc-PSMA-I&T Synthesis
par: Anton A. Larenkov, et autres
Publié: (2021)

The Effectiveness in Activating M-Type K<sup>+</sup> Current Produced by Solifenacin ([(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate): Independent of Its Antimuscarinic Action
par: Hsin-Yen Cho, et autres
Publié: (2021)

Structural Insights into Ca<sup>2+</sup> Permeation through Orai Channels
par: Yang Li, et autres
Publié: (2021)

Mucus phosphoproteins as an indirect measure of endocrine disruption in native small-bodied freshwater fish, exposed to wastewater treatment plant and pulp and paper mill effluents
par: Bahamonde,Paulina, et autres
Publié: (2019)

In Vitro Evaluation of a Solid Supersaturated Self Nanoemulsifying Drug Delivery System (Super-SNEDDS) of Aprepitant for Enhanced Solubility
par: Hakan Nazlı, et autres
Publié: (2021)

Dose-Dependent Outcome of EBV Infection of Humanized Mice Based on Green Raji Unit (GRU) Doses
par: Haiwen Chen, et autres
Publié: (2021)

Differential Physiological Responses to Salt Stress between Salt-Sensitive and Salt-Tolerant <i>japonica</i> Rice Cultivars at the Post-Germination and Seedling Stages
par: Shenghai Ye, et autres
Publié: (2021)

Preparation of Eu<sub>0.075</sub>Tb<sub>0.925</sub>-Metal Organic Framework as a Fluorescent Probe and Application in the Detection of Fe<sup>3+</sup> and Cr<sub>2</sub>O<sub>7</sub><sup>2−</sup>
par: Jie Yin, et autres
Publié: (2021)

Physicochemical and Biological Characterization of rhC1INH Expressed in CHO Cells
par: Ekaterina Zubareva, et autres
Publié: (2021)

A Rapid and Simple Multiparameter Assay to Quantify Spike-Specific CD4 and CD8 T Cells after SARS-CoV-2 Vaccination: A Preliminary Report
par: Mojtaba Shekarkar Azgomi, et autres
Publié: (2021)

Novel Photoinduced Squalene Cyclic Peroxide Identified, Detected, and Quantified in Human Skin Surface Lipids
par: Saoussane Khalifa, et autres
Publié: (2021)

Clinical and immunological characteristic of natural course at the early stages of HIV infection
par: E. R. Manapova, et autres
Publié: (2020)

Amino Acids 785, 787 of the Na<sup>+</sup>/H<sup>+</sup> Exchanger Cytoplasmic Tail Modulate Protein Activity and Tail Conformation
par: Xiuju Li, et autres
Publié: (2021)

Green Synthesis of Carbon-Encapsulated Magnetic Fe<sub>3</sub>O<sub>4</sub> Nanoparticles Using Hydrothermal Carbonization from Rattan Holocelluloses
par: Linxin Dai, et autres
Publié: (2021)

Orai1–STIM1 Regulates Increased Ca<sup>2+</sup> Mobilization, Leading to Contractile Duchenne Muscular Dystrophy Phenotypes in Patient-Derived Induced Pluripotent Stem Cells
par: Tomoya Uchimura, et autres
Publié: (2021)

Distinct Effects of Ibrutinib and Acalabrutinib on Mouse Atrial and Sinoatrial Node Electrophysiology and Arrhythmogenesis
par: Jari M. Tuomi, et autres
Publié: (2021)

Late Na<sup>+</sup> Current Is [Ca<sup>2+</sup>]<sub>i</sub>-Dependent in Canine Ventricular Myocytes
par: Dénes Kiss, et autres
Publié: (2021)

Human Parainfluenza Virus 3 Phosphoprotein Is a Tetramer and Shares Structural and Interaction Features with Ebola Phosphoprotein VP35
par: Joaquin Rodriguez Galvan, et autres
Publié: (2021)

EFFECT OF PENTACHLOROPHENOL ON SELECTED SOIL ENZYME ACTIVITIES IN A CHILEAN ANDISOL
par: Diez J,M. Cristina, et autres
Publié: (2006)

Enfermedad de Paget en Chile: una serie de 15 pacientes
par: González V,Gilberto, et autres
Publié: (2003)

Prostatic acid phosphatase in serum and semen of dogs
par: Gadelha,CRF, et autres
Publié: (2013)

Tridax procumbens flavonoids promote osteoblast differentiation and bone formation
par: Mamun,Md. Abdullah Al, et autres
Publié: (2015)

The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex
par: Muniyandi Selvaraj, et autres
Publié: (2018)

Piezoelectric A<sup>15</sup>B<sup>16</sup>C<sup>17</sup> Compounds and Their Nanocomposites for Energy Harvesting and Sensors: A Review
par: Piotr Szperlich
Publié: (2021)

Exploring Consensus on Preventive Measures and Identification of Patients at Risk of Age-Related Macular Degeneration Using the Delphi Process
par: Alfredo García-Layana, et autres
Publié: (2021)

<sup>1</sup>H-NMR Metabolomics as a Tool for Winemaking Monitoring
par: Inès Le Mao, et autres
Publié: (2021)

Characterization of Biochars Produced by Co-Pyrolysis of Hami Melon (Cantaloupes) Straw Mixed with Polypropylene and Their Adsorption Properties of Cadmium
par: Changheng Li, et autres
Publié: (2021)