Similarities and Differences between COVID-19-Associated Nephropathy and HIV-Associated Nephropathy

Kidney disease is a major complication of viral infection, which can cause both acute and chronic kidney diseases via different mechanisms such as immune-mediated injury, kidney cell injury from a direct viral infection, systemic effects, and antiviral drug-induced nephrotoxicity. HIV-associated nep...

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Autores principales:	Anqun Chen, Lijun Yin, Kyung Lee, John Cijiang He
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	viral nephropathy hiv-associated nephropathy covid-19 nephropathy acute kidney injury collapsing fsgs Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/d35022ac981144c39ee8f1bf1cac04df
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spelling	oai:doaj.org-article:d35022ac981144c39ee8f1bf1cac04df2021-12-02T12:40:23ZSimilarities and Differences between COVID-19-Associated Nephropathy and HIV-Associated Nephropathy2296-93812296-935710.1159/000520235https://doaj.org/article/d35022ac981144c39ee8f1bf1cac04df2021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520235https://doaj.org/toc/2296-9381https://doaj.org/toc/2296-9357Kidney disease is a major complication of viral infection, which can cause both acute and chronic kidney diseases via different mechanisms such as immune-mediated injury, kidney cell injury from a direct viral infection, systemic effects, and antiviral drug-induced nephrotoxicity. HIV-associated nephropathy (HIVAN), characterized by collapsing focal segmental glomerulosclerosis (cFSGS), has been described 2 decades ago as a major complication of acquired-immunodeficiency syndrome. The pathogenesis of HIVAN has been well studied, including viral entry, host response, and genetic factors. The incidence of this disease has been dramatically dropped with current antiretroviral therapy. In the recent severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic, acute kidney injury was also found to be a major complication in patients with (coronavirus disease) COVID-19. These patients also developed glomerular disease such as cFSGS in African Americans with apolipoprotein L1 risk alleles, similar to HIVAN. Whether SARS-CoV-2 can infect kidney cells locally remains controversial, but both local infection and systemic effects are likely involved in the pathogenesis of this disease. In this review, we present a comparison of the clinical presentations, pathological findings, disease mechanisms, and potential treatments between HIVAN and COVID-19. Leveraging the knowledge in HIVAN and experimental approaches used to study HIVAN will facilitate the exploration in the pathogenesis of COVID-19-associated kidney disease and improve our management of COVID-19 patients.Anqun ChenLijun YinKyung LeeJohn Cijiang HeKarger Publishersarticleviral nephropathyhiv-associated nephropathycovid-19 nephropathyacute kidney injurycollapsing fsgsInternal medicineRC31-1245ENKidney Diseases, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	viral nephropathy hiv-associated nephropathy covid-19 nephropathy acute kidney injury collapsing fsgs Internal medicine RC31-1245
spellingShingle	viral nephropathy hiv-associated nephropathy covid-19 nephropathy acute kidney injury collapsing fsgs Internal medicine RC31-1245 Anqun Chen Lijun Yin Kyung Lee John Cijiang He Similarities and Differences between COVID-19-Associated Nephropathy and HIV-Associated Nephropathy
description	Kidney disease is a major complication of viral infection, which can cause both acute and chronic kidney diseases via different mechanisms such as immune-mediated injury, kidney cell injury from a direct viral infection, systemic effects, and antiviral drug-induced nephrotoxicity. HIV-associated nephropathy (HIVAN), characterized by collapsing focal segmental glomerulosclerosis (cFSGS), has been described 2 decades ago as a major complication of acquired-immunodeficiency syndrome. The pathogenesis of HIVAN has been well studied, including viral entry, host response, and genetic factors. The incidence of this disease has been dramatically dropped with current antiretroviral therapy. In the recent severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic, acute kidney injury was also found to be a major complication in patients with (coronavirus disease) COVID-19. These patients also developed glomerular disease such as cFSGS in African Americans with apolipoprotein L1 risk alleles, similar to HIVAN. Whether SARS-CoV-2 can infect kidney cells locally remains controversial, but both local infection and systemic effects are likely involved in the pathogenesis of this disease. In this review, we present a comparison of the clinical presentations, pathological findings, disease mechanisms, and potential treatments between HIVAN and COVID-19. Leveraging the knowledge in HIVAN and experimental approaches used to study HIVAN will facilitate the exploration in the pathogenesis of COVID-19-associated kidney disease and improve our management of COVID-19 patients.
format	article
author	Anqun Chen Lijun Yin Kyung Lee John Cijiang He
author_facet	Anqun Chen Lijun Yin Kyung Lee John Cijiang He
author_sort	Anqun Chen
title	Similarities and Differences between COVID-19-Associated Nephropathy and HIV-Associated Nephropathy
title_short	Similarities and Differences between COVID-19-Associated Nephropathy and HIV-Associated Nephropathy
title_full	Similarities and Differences between COVID-19-Associated Nephropathy and HIV-Associated Nephropathy
title_fullStr	Similarities and Differences between COVID-19-Associated Nephropathy and HIV-Associated Nephropathy
title_full_unstemmed	Similarities and Differences between COVID-19-Associated Nephropathy and HIV-Associated Nephropathy
title_sort	similarities and differences between covid-19-associated nephropathy and hiv-associated nephropathy
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/d35022ac981144c39ee8f1bf1cac04df
work_keys_str_mv	AT anqunchen similaritiesanddifferencesbetweencovid19associatednephropathyandhivassociatednephropathy AT lijunyin similaritiesanddifferencesbetweencovid19associatednephropathyandhivassociatednephropathy AT kyunglee similaritiesanddifferencesbetweencovid19associatednephropathyandhivassociatednephropathy AT johncijianghe similaritiesanddifferencesbetweencovid19associatednephropathyandhivassociatednephropathy
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Similarities and Differences between COVID-19-Associated Nephropathy and HIV-Associated Nephropathy

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