Are statins beneficial for the treatment of pulmonary hypertension?

Pulmonary hypertension (PH) is a condition characterized by vasoconstriction and vascular remodeling with a poor prognosis. The current medical treatments available are supportive care therapy and pulmonary vascular-targeted therapy. Targeted treatments for PH include prostacyclin analogs, endotheli...

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Autores principales:	Lei Wang, Ting Yang, Chen Wang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2017
Materias:	Pulmonary hypertension Statins Mechanism Clinical effect Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d3517b25afc84a6eb64de8f4ea03b866
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spelling	oai:doaj.org-article:d3517b25afc84a6eb64de8f4ea03b8662021-12-02T12:57:34ZAre statins beneficial for the treatment of pulmonary hypertension?2095-882X10.1016/j.cdtm.2017.10.001https://doaj.org/article/d3517b25afc84a6eb64de8f4ea03b8662017-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X1730035Xhttps://doaj.org/toc/2095-882XPulmonary hypertension (PH) is a condition characterized by vasoconstriction and vascular remodeling with a poor prognosis. The current medical treatments available are supportive care therapy and pulmonary vascular-targeted therapy. Targeted treatments for PH include prostacyclin analogs, endothelin receptor antagonists, and phosphodiesterase type 5 inhibitors; however, these treatments cannot reverse pulmonary vascular remodeling. Recently, many novel treatment options involving drugs such as statins have been emerging. In this review, we attempt to summarize the current knowledge of the role of statins in PH treatment and their potential clinical effects. Many basic researches have proved that statins can be helpful for the treatment of PH both in vitro and in experimental models. The main mechanisms underlying the effects of statins are restoration of endothelial function, attenuation of pulmonary vascular remodeling, regulation of gene expression, regulation of intracellular signaling processes involved in PH, anti-inflammatory responses, and synergy with other targeted drugs. Nevertheless, clinical researches, especially randomized controlled trials for PH are rare. The current clinical researches show contrasting results on the clinical effects of statins in patients with PH. Carefully designed randomized, controlled trials are needed to test the safety and efficacy of statins for PH treatment.Lei WangTing YangChen WangKeAi Communications Co., Ltd.articlePulmonary hypertensionStatinsMechanismClinical effectMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 3, Iss 4, Pp 213-220 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pulmonary hypertension Statins Mechanism Clinical effect Medicine (General) R5-920
spellingShingle	Pulmonary hypertension Statins Mechanism Clinical effect Medicine (General) R5-920 Lei Wang Ting Yang Chen Wang Are statins beneficial for the treatment of pulmonary hypertension?
description	Pulmonary hypertension (PH) is a condition characterized by vasoconstriction and vascular remodeling with a poor prognosis. The current medical treatments available are supportive care therapy and pulmonary vascular-targeted therapy. Targeted treatments for PH include prostacyclin analogs, endothelin receptor antagonists, and phosphodiesterase type 5 inhibitors; however, these treatments cannot reverse pulmonary vascular remodeling. Recently, many novel treatment options involving drugs such as statins have been emerging. In this review, we attempt to summarize the current knowledge of the role of statins in PH treatment and their potential clinical effects. Many basic researches have proved that statins can be helpful for the treatment of PH both in vitro and in experimental models. The main mechanisms underlying the effects of statins are restoration of endothelial function, attenuation of pulmonary vascular remodeling, regulation of gene expression, regulation of intracellular signaling processes involved in PH, anti-inflammatory responses, and synergy with other targeted drugs. Nevertheless, clinical researches, especially randomized controlled trials for PH are rare. The current clinical researches show contrasting results on the clinical effects of statins in patients with PH. Carefully designed randomized, controlled trials are needed to test the safety and efficacy of statins for PH treatment.
format	article
author	Lei Wang Ting Yang Chen Wang
author_facet	Lei Wang Ting Yang Chen Wang
author_sort	Lei Wang
title	Are statins beneficial for the treatment of pulmonary hypertension?
title_short	Are statins beneficial for the treatment of pulmonary hypertension?
title_full	Are statins beneficial for the treatment of pulmonary hypertension?
title_fullStr	Are statins beneficial for the treatment of pulmonary hypertension?
title_full_unstemmed	Are statins beneficial for the treatment of pulmonary hypertension?
title_sort	are statins beneficial for the treatment of pulmonary hypertension?
publisher	KeAi Communications Co., Ltd.
publishDate	2017
url	https://doaj.org/article/d3517b25afc84a6eb64de8f4ea03b866
work_keys_str_mv	AT leiwang arestatinsbeneficialforthetreatmentofpulmonaryhypertension AT tingyang arestatinsbeneficialforthetreatmentofpulmonaryhypertension AT chenwang arestatinsbeneficialforthetreatmentofpulmonaryhypertension
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Are statins beneficial for the treatment of pulmonary hypertension?

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