Novel Application of the Traditional Lipid Ratios as Strong Risk Predictors of NASH

Mona Hegazy,1 Shereen A Saleh,2 Ahmed Ezzat,1 Mervat E Behiry1 1Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Internal Medicine, Faculty of Medicine, Ain-Shams University, Cairo, EgyptCorrespondence: Mona HegazyInternal Medicine, Faculty of Medicine, Cairo University, Vill...

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Autores principales:	Hegazy M, Saleh SA, Ezzat A, Behiry ME
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	nonalcoholic steatohepatitis triglycerides/hdl total cholesterol/hdl ldl/hdl borderline nash Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/d3521a83fceb4bb4b7ac0f2ce890f406
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spelling	oai:doaj.org-article:d3521a83fceb4bb4b7ac0f2ce890f4062021-12-02T09:09:59ZNovel Application of the Traditional Lipid Ratios as Strong Risk Predictors of NASH1178-7007https://doaj.org/article/d3521a83fceb4bb4b7ac0f2ce890f4062020-02-01T00:00:00Zhttps://www.dovepress.com/novel-application-of-the-traditional-lipid-ratios-as-strong-risk-predi-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Mona Hegazy,1 Shereen A Saleh,2 Ahmed Ezzat,1 Mervat E Behiry1 1Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Internal Medicine, Faculty of Medicine, Ain-Shams University, Cairo, EgyptCorrespondence: Mona HegazyInternal Medicine, Faculty of Medicine, Cairo University, Villa 22A, Compound First Heights, 6th of October City, Cairo 14651, EgyptTel +20 1001421551Email monahegazy@hotmail.comPurpose: Limited data are available regarding the role of triglycerides, cholesterol and lipoproteins ratios as risk factors for nonalcoholic fatty liver disease (NAFLD) progression. In the present study, the investigators aimed to investigate the value of cardiovascular risk ratios of triglycerides, cholesterol, and lipoproteins as predictors of nonalcoholic steatohepatitis (NASH) and the correlation of such ratios with disease severity.Patients and Methods: This study included 131 overweight and obese patients with NAFLD who were divided into NASH, borderline NASH, and non-NASH fatty liver (NNFL) subgroups according to NAFLD activity score (NAS) in liver biopsy, and 60 healthy participants as a control group. Lipid profile and lipid ratios including triglycerides/HDL (TGs/HDL), low-density lipoprotein/high-density lipoprotein (LDL/HDL) and total cholesterol/HDL (TC/HDL) ratios were measured.Results: Significantly higher triglycerides/HDL ratio was found in NASH and borderline NASH, while higher cholesterol/HDL ratio was found in borderline NASH in comparison to controls. There were positive correlations between TGs/HDL and steatosis, ballooning, inflammation, BMI, and NAS; between LDL/HDL and inflammation; and between cholesterol/HDL and BMI, steatosis, and NAS. The highest AUC was that of TG/HDL (0.744), at a cut-off point of 3, with 71.8% sensitivity and 76.8% specificity.Conclusion: Triglycerides, cholesterol and lipoprotein ratios showed higher levels in NASH and correlated with NAFLD severity, and above these cut-off ratios, we can rule in the NASH cases which confer also the cardiovascular morbidities. Structured lipid ratios could serve as markers to screen NASH progression from simple steatosis cases and clarify the link of NASH with the cardiovascular risk prediction in overweight and obese patients.Keywords: nonalcoholic steatohepatitis, triglycerides/HDL, total cholesterol/HDL, LDL/HDL, borderline NASHHegazy MSaleh SAEzzat ABehiry MEDove Medical Pressarticlenonalcoholic steatohepatitistriglycerides/hdltotal cholesterol/hdlldl/hdlborderline nashSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 297-305 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nonalcoholic steatohepatitis triglycerides/hdl total cholesterol/hdl ldl/hdl borderline nash Specialties of internal medicine RC581-951
spellingShingle	nonalcoholic steatohepatitis triglycerides/hdl total cholesterol/hdl ldl/hdl borderline nash Specialties of internal medicine RC581-951 Hegazy M Saleh SA Ezzat A Behiry ME Novel Application of the Traditional Lipid Ratios as Strong Risk Predictors of NASH
description	Mona Hegazy,1 Shereen A Saleh,2 Ahmed Ezzat,1 Mervat E Behiry1 1Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Internal Medicine, Faculty of Medicine, Ain-Shams University, Cairo, EgyptCorrespondence: Mona HegazyInternal Medicine, Faculty of Medicine, Cairo University, Villa 22A, Compound First Heights, 6th of October City, Cairo 14651, EgyptTel +20 1001421551Email monahegazy@hotmail.comPurpose: Limited data are available regarding the role of triglycerides, cholesterol and lipoproteins ratios as risk factors for nonalcoholic fatty liver disease (NAFLD) progression. In the present study, the investigators aimed to investigate the value of cardiovascular risk ratios of triglycerides, cholesterol, and lipoproteins as predictors of nonalcoholic steatohepatitis (NASH) and the correlation of such ratios with disease severity.Patients and Methods: This study included 131 overweight and obese patients with NAFLD who were divided into NASH, borderline NASH, and non-NASH fatty liver (NNFL) subgroups according to NAFLD activity score (NAS) in liver biopsy, and 60 healthy participants as a control group. Lipid profile and lipid ratios including triglycerides/HDL (TGs/HDL), low-density lipoprotein/high-density lipoprotein (LDL/HDL) and total cholesterol/HDL (TC/HDL) ratios were measured.Results: Significantly higher triglycerides/HDL ratio was found in NASH and borderline NASH, while higher cholesterol/HDL ratio was found in borderline NASH in comparison to controls. There were positive correlations between TGs/HDL and steatosis, ballooning, inflammation, BMI, and NAS; between LDL/HDL and inflammation; and between cholesterol/HDL and BMI, steatosis, and NAS. The highest AUC was that of TG/HDL (0.744), at a cut-off point of 3, with 71.8% sensitivity and 76.8% specificity.Conclusion: Triglycerides, cholesterol and lipoprotein ratios showed higher levels in NASH and correlated with NAFLD severity, and above these cut-off ratios, we can rule in the NASH cases which confer also the cardiovascular morbidities. Structured lipid ratios could serve as markers to screen NASH progression from simple steatosis cases and clarify the link of NASH with the cardiovascular risk prediction in overweight and obese patients.Keywords: nonalcoholic steatohepatitis, triglycerides/HDL, total cholesterol/HDL, LDL/HDL, borderline NASH
format	article
author	Hegazy M Saleh SA Ezzat A Behiry ME
author_facet	Hegazy M Saleh SA Ezzat A Behiry ME
author_sort	Hegazy M
title	Novel Application of the Traditional Lipid Ratios as Strong Risk Predictors of NASH
title_short	Novel Application of the Traditional Lipid Ratios as Strong Risk Predictors of NASH
title_full	Novel Application of the Traditional Lipid Ratios as Strong Risk Predictors of NASH
title_fullStr	Novel Application of the Traditional Lipid Ratios as Strong Risk Predictors of NASH
title_full_unstemmed	Novel Application of the Traditional Lipid Ratios as Strong Risk Predictors of NASH
title_sort	novel application of the traditional lipid ratios as strong risk predictors of nash
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d3521a83fceb4bb4b7ac0f2ce890f406
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Novel Application of the Traditional Lipid Ratios as Strong Risk Predictors of NASH

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