Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study

Background: Non-alcoholic fatty liver disease (NAFLD) is a pathological condition, ranging from fatty liver to chronic steatohepatitis (NASH), liver cirrhosis, and eventually to hepatocellular carcinoma. Recent findings suggest that patients with NAFLD have an increased risk of cardiovascular events...

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Autores principales:	Antonio Gidaro, Roberto Manetti, Alessandro Palmerio Delitala, Emanuele Salvi, Luigi Bergamaschini, Gianpaolo Vidili, Roberto Castelli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	non-alcoholic fatty liver disease (NAFLD) insulin resistance plasminogen activator inhibitor-1 (PAI-1) von Willebrand factor (VWF) factor VII (FVII) slimming Medicine R
Acceso en línea:	https://doaj.org/article/d352f62501994fd393d03ea0c7b848e4
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spelling	oai:doaj.org-article:d352f62501994fd393d03ea0c7b848e42021-11-11T17:33:40ZProthrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study10.3390/jcm102149062077-0383https://doaj.org/article/d352f62501994fd393d03ea0c7b848e42021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4906https://doaj.org/toc/2077-0383Background: Non-alcoholic fatty liver disease (NAFLD) is a pathological condition, ranging from fatty liver to chronic steatohepatitis (NASH), liver cirrhosis, and eventually to hepatocellular carcinoma. Recent findings suggest that patients with NAFLD have an increased risk of cardiovascular events and thromboembolism, which is independent of metabolic diseases that are frequently associated with NAFLD, such as diabetes, hyperlipidemia, and obesity. Methods: We evaluated 30 NAFLD patients, before and after weight loss. Plasma levels of C-reactive protein (CRP), fibrinogen, plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (VWF), homocysteine, coagulation protein S, Thrombin activable fibrinolysis inhibitor (TAFI), and factor VII (FVII) were assessed to evaluate whether they should be responsible of the prothrombotic state of NAFLD after weight loss. Results: At baseline, patients affected by NAFLD had a significantly higher levels of CRP, fibrinogen, PAI-1, VWF antigen, and FVII levels. After weight reduction, we observed a significant drop of inflammatory and prothrombotic markers, as well as glucometabolic, lipid profile. Conclusion: These findings provide evidence for a link between NAFLD/NASH and thromboembolism. The association seems to be linked with primitive thrombotic state and hypercoagulation due to increased levels of coagulation factors and reduced levels of PAI-1. This hypercoagulation state might explain increased levels of thrombosis and splanchnic thrombosis observed in NASH correlated cirrhosis.Antonio GidaroRoberto ManettiAlessandro Palmerio DelitalaEmanuele SalviLuigi BergamaschiniGianpaolo VidiliRoberto CastelliMDPI AGarticlenon-alcoholic fatty liver disease (NAFLD)insulin resistanceplasminogen activator inhibitor-1 (PAI-1)von Willebrand factor (VWF)factor VII (FVII)slimmingMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4906, p 4906 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-alcoholic fatty liver disease (NAFLD) insulin resistance plasminogen activator inhibitor-1 (PAI-1) von Willebrand factor (VWF) factor VII (FVII) slimming Medicine R
spellingShingle	non-alcoholic fatty liver disease (NAFLD) insulin resistance plasminogen activator inhibitor-1 (PAI-1) von Willebrand factor (VWF) factor VII (FVII) slimming Medicine R Antonio Gidaro Roberto Manetti Alessandro Palmerio Delitala Emanuele Salvi Luigi Bergamaschini Gianpaolo Vidili Roberto Castelli Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study
description	Background: Non-alcoholic fatty liver disease (NAFLD) is a pathological condition, ranging from fatty liver to chronic steatohepatitis (NASH), liver cirrhosis, and eventually to hepatocellular carcinoma. Recent findings suggest that patients with NAFLD have an increased risk of cardiovascular events and thromboembolism, which is independent of metabolic diseases that are frequently associated with NAFLD, such as diabetes, hyperlipidemia, and obesity. Methods: We evaluated 30 NAFLD patients, before and after weight loss. Plasma levels of C-reactive protein (CRP), fibrinogen, plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (VWF), homocysteine, coagulation protein S, Thrombin activable fibrinolysis inhibitor (TAFI), and factor VII (FVII) were assessed to evaluate whether they should be responsible of the prothrombotic state of NAFLD after weight loss. Results: At baseline, patients affected by NAFLD had a significantly higher levels of CRP, fibrinogen, PAI-1, VWF antigen, and FVII levels. After weight reduction, we observed a significant drop of inflammatory and prothrombotic markers, as well as glucometabolic, lipid profile. Conclusion: These findings provide evidence for a link between NAFLD/NASH and thromboembolism. The association seems to be linked with primitive thrombotic state and hypercoagulation due to increased levels of coagulation factors and reduced levels of PAI-1. This hypercoagulation state might explain increased levels of thrombosis and splanchnic thrombosis observed in NASH correlated cirrhosis.
format	article
author	Antonio Gidaro Roberto Manetti Alessandro Palmerio Delitala Emanuele Salvi Luigi Bergamaschini Gianpaolo Vidili Roberto Castelli
author_facet	Antonio Gidaro Roberto Manetti Alessandro Palmerio Delitala Emanuele Salvi Luigi Bergamaschini Gianpaolo Vidili Roberto Castelli
author_sort	Antonio Gidaro
title	Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study
title_short	Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study
title_full	Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study
title_fullStr	Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study
title_full_unstemmed	Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study
title_sort	prothrombotic and inflammatory markers in elderly patients with non-alcoholic hepatic liver disease before and after weight loss: a pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d352f62501994fd393d03ea0c7b848e4
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Prothrombotic and Inflammatory Markers in Elderly Patients with Non-Alcoholic Hepatic Liver Disease before and after Weight Loss: A Pilot Study

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