A novel sol-gel-derived calcium silicate cement with short setting time for application in endodontic repair of perforations

Bor-Shiunn Lee,1,2 Hong-Ping Lin,3 Jerry Chun-Chung Chan,4 Wei-Chuan Wang,2 Ping-Hsuan Hung,2 Yu-Hsin Tsai,4 Yuan-Ling Lee1,2 1Graduate Institute of Oral Biology, 2Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University and Hospital, Taipei, 3Department of Chemistr...

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Autores principales:	Lee BS, Lin HP, Chan JCC, Wang WC, Hung PH, Tsai YH, Lee YL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	acidic environment compressive strength mesoporous mineral trioxide aggregate mixing order sol-gel reaction Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d354df21eacd4627b7d70128efcc7002
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spelling	oai:doaj.org-article:d354df21eacd4627b7d70128efcc70022021-12-02T04:25:22ZA novel sol-gel-derived calcium silicate cement with short setting time for application in endodontic repair of perforations1178-2013https://doaj.org/article/d354df21eacd4627b7d70128efcc70022018-01-01T00:00:00Zhttps://www.dovepress.com/a-novel-sol-gel-derived-calcium-silicate-cement-with-short-setting-tim-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Bor-Shiunn Lee,1,2 Hong-Ping Lin,3 Jerry Chun-Chung Chan,4 Wei-Chuan Wang,2 Ping-Hsuan Hung,2 Yu-Hsin Tsai,4 Yuan-Ling Lee1,2 1Graduate Institute of Oral Biology, 2Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University and Hospital, Taipei, 3Department of Chemistry, National Cheng Kung University, Tainan, 4Department of Chemistry, National Taiwan University, Taipei, Taiwan, Republic of China Abstract: Mineral trioxide aggregate (MTA) is the most frequently used repair material in endodontics, but the long setting time and reduced mechanical strength in acidic environments are major shortcomings. In this study, a novel sol-gel-derived calcium silicate cement (sCSC) was developed using an initial Ca/Si molar ratio of 3, with the most effective mixing orders of reactants and optimal HNO3 catalyst volumes. A Fourier transform infrared spectrometer, scanning electron microscope with energy-dispersive X-ray spectroscopy, and X-ray powder diffractometer were used for material characterization. The setting time, compressive strength, and microhardness of sCSC after hydration in neutral and pH 5 environments were compared with that of MTA. Results showed that sCSC demonstrated porous microstructures with a setting time of ~30 min, and the major components of sCSC were tricalcium silicate, dicalcium silicate, and calcium oxide. The optimal formula of sCSC was sn200, which exhibited significantly higher compressive strength and microhardness than MTA, irrespective of neutral or pH 5 environments. In addition, both sn200 and MTA demonstrated good biocompatibility because cell viability was similar to that of the control. These findings suggest that sn200 merits further clinical study for potential application in endodontic repair of perforations. Keywords: acidic environment, compressive strength, mesoporous, mineral trioxide aggregate, mixing order, sol-gel reactionLee BSLin HPChan JCCWang WCHung PHTsai YHLee YLDove Medical Pressarticleacidic environmentcompressive strengthmesoporousmineral trioxide aggregatemixing ordersol-gel reactionMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 261-271 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	acidic environment compressive strength mesoporous mineral trioxide aggregate mixing order sol-gel reaction Medicine (General) R5-920
spellingShingle	acidic environment compressive strength mesoporous mineral trioxide aggregate mixing order sol-gel reaction Medicine (General) R5-920 Lee BS Lin HP Chan JCC Wang WC Hung PH Tsai YH Lee YL A novel sol-gel-derived calcium silicate cement with short setting time for application in endodontic repair of perforations
description	Bor-Shiunn Lee,1,2 Hong-Ping Lin,3 Jerry Chun-Chung Chan,4 Wei-Chuan Wang,2 Ping-Hsuan Hung,2 Yu-Hsin Tsai,4 Yuan-Ling Lee1,2 1Graduate Institute of Oral Biology, 2Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University and Hospital, Taipei, 3Department of Chemistry, National Cheng Kung University, Tainan, 4Department of Chemistry, National Taiwan University, Taipei, Taiwan, Republic of China Abstract: Mineral trioxide aggregate (MTA) is the most frequently used repair material in endodontics, but the long setting time and reduced mechanical strength in acidic environments are major shortcomings. In this study, a novel sol-gel-derived calcium silicate cement (sCSC) was developed using an initial Ca/Si molar ratio of 3, with the most effective mixing orders of reactants and optimal HNO3 catalyst volumes. A Fourier transform infrared spectrometer, scanning electron microscope with energy-dispersive X-ray spectroscopy, and X-ray powder diffractometer were used for material characterization. The setting time, compressive strength, and microhardness of sCSC after hydration in neutral and pH 5 environments were compared with that of MTA. Results showed that sCSC demonstrated porous microstructures with a setting time of ~30 min, and the major components of sCSC were tricalcium silicate, dicalcium silicate, and calcium oxide. The optimal formula of sCSC was sn200, which exhibited significantly higher compressive strength and microhardness than MTA, irrespective of neutral or pH 5 environments. In addition, both sn200 and MTA demonstrated good biocompatibility because cell viability was similar to that of the control. These findings suggest that sn200 merits further clinical study for potential application in endodontic repair of perforations. Keywords: acidic environment, compressive strength, mesoporous, mineral trioxide aggregate, mixing order, sol-gel reaction
format	article
author	Lee BS Lin HP Chan JCC Wang WC Hung PH Tsai YH Lee YL
author_facet	Lee BS Lin HP Chan JCC Wang WC Hung PH Tsai YH Lee YL
author_sort	Lee BS
title	A novel sol-gel-derived calcium silicate cement with short setting time for application in endodontic repair of perforations
title_short	A novel sol-gel-derived calcium silicate cement with short setting time for application in endodontic repair of perforations
title_full	A novel sol-gel-derived calcium silicate cement with short setting time for application in endodontic repair of perforations
title_fullStr	A novel sol-gel-derived calcium silicate cement with short setting time for application in endodontic repair of perforations
title_full_unstemmed	A novel sol-gel-derived calcium silicate cement with short setting time for application in endodontic repair of perforations
title_sort	novel sol-gel-derived calcium silicate cement with short setting time for application in endodontic repair of perforations
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d354df21eacd4627b7d70128efcc7002
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A novel sol-gel-derived calcium silicate cement with short setting time for application in endodontic repair of perforations

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