Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of <i>Bjerkandera adusta</i> CCBAS 930

The aim of this study was to evaluate the bioremoval of anthracycline antibiotics (daunomycin-DNR, doxorubicin–DOX, and mitoxantrone-MTX) by immobilized mycelium of <i>B. adusta</i> CCBAS 930. The activity of oxidoreductases: versatile peroxidases (VP), superoxide dismutase (SOD), catala...

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Autor principal:	Kamila Rybczyńska-Tkaczyk
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	daunomycin doxorubicin mitoxantrone versatile peroxidases genotoxicity biotoxicity Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/d3564db42805457abee4c551eae680e8
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spelling	oai:doaj.org-article:d3564db42805457abee4c551eae680e82021-11-25T18:27:40ZEnhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of <i>Bjerkandera adusta</i> CCBAS 93010.3390/molecules262268421420-3049https://doaj.org/article/d3564db42805457abee4c551eae680e82021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6842https://doaj.org/toc/1420-3049The aim of this study was to evaluate the bioremoval of anthracycline antibiotics (daunomycin-DNR, doxorubicin–DOX, and mitoxantrone-MTX) by immobilized mycelium of <i>B. adusta</i> CCBAS 930. The activity of oxidoreductases: versatile peroxidases (VP), superoxide dismutase (SOD), catalase (CAT), and glucose oxidase (GOX), and the levels of phenolic compounds (PhC) and free radicals (SOR) were determined during the biotransformation of anthracyclines by <i>B. adusta</i> strain CCBAS 930. Moreover, the phytotoxicity (<i>Lepidium sativum</i> L.), biotoxicity (MARA assay), and genotoxicity of anthracyclines were evaluated after biological treatment. After 120 h, more than 90% of anthracyclines were removed by the immobilized mycelium of <i>B. adusta</i> CCBAS 930. The effective biotransformation of anthracyclines was correlated with detoxification and reduced genotoxicity.Kamila Rybczyńska-TkaczykMDPI AGarticledaunomycindoxorubicinmitoxantroneversatile peroxidasesgenotoxicitybiotoxicityOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6842, p 6842 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	daunomycin doxorubicin mitoxantrone versatile peroxidases genotoxicity biotoxicity Organic chemistry QD241-441
spellingShingle	daunomycin doxorubicin mitoxantrone versatile peroxidases genotoxicity biotoxicity Organic chemistry QD241-441 Kamila Rybczyńska-Tkaczyk Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of <i>Bjerkandera adusta</i> CCBAS 930
description	The aim of this study was to evaluate the bioremoval of anthracycline antibiotics (daunomycin-DNR, doxorubicin–DOX, and mitoxantrone-MTX) by immobilized mycelium of <i>B. adusta</i> CCBAS 930. The activity of oxidoreductases: versatile peroxidases (VP), superoxide dismutase (SOD), catalase (CAT), and glucose oxidase (GOX), and the levels of phenolic compounds (PhC) and free radicals (SOR) were determined during the biotransformation of anthracyclines by <i>B. adusta</i> strain CCBAS 930. Moreover, the phytotoxicity (<i>Lepidium sativum</i> L.), biotoxicity (MARA assay), and genotoxicity of anthracyclines were evaluated after biological treatment. After 120 h, more than 90% of anthracyclines were removed by the immobilized mycelium of <i>B. adusta</i> CCBAS 930. The effective biotransformation of anthracyclines was correlated with detoxification and reduced genotoxicity.
format	article
author	Kamila Rybczyńska-Tkaczyk
author_facet	Kamila Rybczyńska-Tkaczyk
author_sort	Kamila Rybczyńska-Tkaczyk
title	Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of <i>Bjerkandera adusta</i> CCBAS 930
title_short	Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of <i>Bjerkandera adusta</i> CCBAS 930
title_full	Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of <i>Bjerkandera adusta</i> CCBAS 930
title_fullStr	Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of <i>Bjerkandera adusta</i> CCBAS 930
title_full_unstemmed	Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of <i>Bjerkandera adusta</i> CCBAS 930
title_sort	enhanced efficiency of the removal of cytostatic anthracycline drugs using immobilized mycelium of <i>bjerkandera adusta</i> ccbas 930
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d3564db42805457abee4c551eae680e8
work_keys_str_mv	AT kamilarybczynskatkaczyk enhancedefficiencyoftheremovalofcytostaticanthracyclinedrugsusingimmobilizedmyceliumofibjerkanderaadustaiccbas930
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Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of <i>Bjerkandera adusta</i> CCBAS 930

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