Atypical depression: current perspectives

Dorota Łojko,1 Janusz K Rybakowski1,2 1Department of Adult Psychiatry, 2Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland Abstract: The history and present status of the definition, prevalence, neurobiology, and treatment of atypical depression (A...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Łojko D, Rybakowski JK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	atypical depression hypersomnia hyperphagia obesity bipolar disorder seasonal affective disorder Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d35756edb3274c5fbc9fd430a2d8ccca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d35756edb3274c5fbc9fd430a2d8ccca
record_format	dspace
spelling	oai:doaj.org-article:d35756edb3274c5fbc9fd430a2d8ccca2021-12-02T00:20:06ZAtypical depression: current perspectives1178-2021https://doaj.org/article/d35756edb3274c5fbc9fd430a2d8ccca2017-09-01T00:00:00Zhttps://www.dovepress.com/atypical-depression-current-perspectives-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Dorota Łojko,1 Janusz K Rybakowski1,2 1Department of Adult Psychiatry, 2Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland Abstract: The history and present status of the definition, prevalence, neurobiology, and treatment of atypical depression (AD) is presented. The concept of AD has evolved through the years, and currently, in Diagnostic and Statistical Manual of Mental Disorders (DSM), Fifth Edition, the specifier of depressive episode with atypical feature is present for both diagnostic groups, that is, depressive disorders and bipolar and related disorders. This specifier includes mood reactivity, hyperphagia, hypersomnia, leaden paralysis, and interpersonal rejection sensitivity. Prevalence rates of AD are variable, depending on the criteria, methodology, and settings. The results of epidemiological studies using DSM criteria suggest that 15%–29% of depressed patients have AD, and the results of clinical studies point to a prevalence of 18%–36%. A relationship of AD with bipolar depression, seasonal depression, and obesity has also been postulated. Pathogenic research has been mostly focused on distinguishing AD from melancholic depression. The differences have been found in biochemical studies in the areas of hypothalamic–pituitary–adrenal axis, inflammatory markers, and the leptin system, although the results obtained are frequently controversial. A number of findings concerning such differences have also been obtained using neuroimaging and neurophysiological and neuropsychological methods. An initial concept of AD as a preferentially monoamine oxidase inhibitor-responsive depression, although confirmed in some further studies, is of limited use nowadays. Currently, despite numerous drug trials, there are no comprehensive treatment guidelines for AD. We finalize the article by describing the future research perspectives for the definition, neurobiology, and treatment. A better specification of diagnostic criteria and description of clinical picture, a genome-wide association study of AD, and establishing updated treatment recommendations for this clinical phenomenon should be the priorities for the coming years. Keywords: hypersomnia, hyperphagia, obesity, bipolar disorder, seasonal affective disorderŁojko DRybakowski JKDove Medical Pressarticleatypical depressionhypersomniahyperphagiaobesitybipolar disorderseasonal affective disorderNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2447-2456 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	atypical depression hypersomnia hyperphagia obesity bipolar disorder seasonal affective disorder Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	atypical depression hypersomnia hyperphagia obesity bipolar disorder seasonal affective disorder Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Łojko D Rybakowski JK Atypical depression: current perspectives
description	Dorota Łojko,1 Janusz K Rybakowski1,2 1Department of Adult Psychiatry, 2Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland Abstract: The history and present status of the definition, prevalence, neurobiology, and treatment of atypical depression (AD) is presented. The concept of AD has evolved through the years, and currently, in Diagnostic and Statistical Manual of Mental Disorders (DSM), Fifth Edition, the specifier of depressive episode with atypical feature is present for both diagnostic groups, that is, depressive disorders and bipolar and related disorders. This specifier includes mood reactivity, hyperphagia, hypersomnia, leaden paralysis, and interpersonal rejection sensitivity. Prevalence rates of AD are variable, depending on the criteria, methodology, and settings. The results of epidemiological studies using DSM criteria suggest that 15%–29% of depressed patients have AD, and the results of clinical studies point to a prevalence of 18%–36%. A relationship of AD with bipolar depression, seasonal depression, and obesity has also been postulated. Pathogenic research has been mostly focused on distinguishing AD from melancholic depression. The differences have been found in biochemical studies in the areas of hypothalamic–pituitary–adrenal axis, inflammatory markers, and the leptin system, although the results obtained are frequently controversial. A number of findings concerning such differences have also been obtained using neuroimaging and neurophysiological and neuropsychological methods. An initial concept of AD as a preferentially monoamine oxidase inhibitor-responsive depression, although confirmed in some further studies, is of limited use nowadays. Currently, despite numerous drug trials, there are no comprehensive treatment guidelines for AD. We finalize the article by describing the future research perspectives for the definition, neurobiology, and treatment. A better specification of diagnostic criteria and description of clinical picture, a genome-wide association study of AD, and establishing updated treatment recommendations for this clinical phenomenon should be the priorities for the coming years. Keywords: hypersomnia, hyperphagia, obesity, bipolar disorder, seasonal affective disorder
format	article
author	Łojko D Rybakowski JK
author_facet	Łojko D Rybakowski JK
author_sort	Łojko D
title	Atypical depression: current perspectives
title_short	Atypical depression: current perspectives
title_full	Atypical depression: current perspectives
title_fullStr	Atypical depression: current perspectives
title_full_unstemmed	Atypical depression: current perspectives
title_sort	atypical depression: current perspectives
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/d35756edb3274c5fbc9fd430a2d8ccca
work_keys_str_mv	AT łojkod atypicaldepressioncurrentperspectives AT rybakowskijk atypicaldepressioncurrentperspectives
_version_	1718403830934142976

Atypical depression: current perspectives

Ejemplares similares