<i>Drosophila</i> Heart as a Model for Cardiac Development and Diseases

The <i>Drosophila</i> heart, also referred to as the dorsal vessel, pumps the insect blood, the hemolymph. The bilateral heart primordia develop from the most dorsally located mesodermal cells, migrate coordinately, and fuse to form the cardiac tube. Though much simpler, the fruit fly he...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anissa Souidi, Krzysztof Jagla
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	heart cardiogenesis <i>Drosophila melanogaster</i> conduction defects arrhythmia congenital cardiomyopathy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d35c9e9f2b5d45ba801f697b16baae6e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d35c9e9f2b5d45ba801f697b16baae6e
record_format	dspace
spelling	oai:doaj.org-article:d35c9e9f2b5d45ba801f697b16baae6e2021-11-25T17:11:17Z<i>Drosophila</i> Heart as a Model for Cardiac Development and Diseases10.3390/cells101130782073-4409https://doaj.org/article/d35c9e9f2b5d45ba801f697b16baae6e2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3078https://doaj.org/toc/2073-4409The <i>Drosophila</i> heart, also referred to as the dorsal vessel, pumps the insect blood, the hemolymph. The bilateral heart primordia develop from the most dorsally located mesodermal cells, migrate coordinately, and fuse to form the cardiac tube. Though much simpler, the fruit fly heart displays several developmental and functional similarities to the vertebrate heart and, as we discuss here, represents an attractive model system for dissecting mechanisms of cardiac aging and heart failure and identifying genes causing congenital heart diseases. Fast imaging technologies allow for the characterization of heartbeat parameters in the adult fly and there is growing evidence that cardiac dysfunction in human diseases could be reproduced and analyzed in <i>Drosophila</i>, as discussed here for heart defects associated with the myotonic dystrophy type 1. Overall, the power of genetics and unsuspected conservation of genes and pathways puts <i>Drosophila</i> at the heart of fundamental and applied cardiac research.Anissa SouidiKrzysztof JaglaMDPI AGarticleheartcardiogenesis<i>Drosophila melanogaster</i>conduction defectsarrhythmiacongenital cardiomyopathyBiology (General)QH301-705.5ENCells, Vol 10, Iss 3078, p 3078 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heart cardiogenesis <i>Drosophila melanogaster</i> conduction defects arrhythmia congenital cardiomyopathy Biology (General) QH301-705.5
spellingShingle	heart cardiogenesis <i>Drosophila melanogaster</i> conduction defects arrhythmia congenital cardiomyopathy Biology (General) QH301-705.5 Anissa Souidi Krzysztof Jagla <i>Drosophila</i> Heart as a Model for Cardiac Development and Diseases
description	The <i>Drosophila</i> heart, also referred to as the dorsal vessel, pumps the insect blood, the hemolymph. The bilateral heart primordia develop from the most dorsally located mesodermal cells, migrate coordinately, and fuse to form the cardiac tube. Though much simpler, the fruit fly heart displays several developmental and functional similarities to the vertebrate heart and, as we discuss here, represents an attractive model system for dissecting mechanisms of cardiac aging and heart failure and identifying genes causing congenital heart diseases. Fast imaging technologies allow for the characterization of heartbeat parameters in the adult fly and there is growing evidence that cardiac dysfunction in human diseases could be reproduced and analyzed in <i>Drosophila</i>, as discussed here for heart defects associated with the myotonic dystrophy type 1. Overall, the power of genetics and unsuspected conservation of genes and pathways puts <i>Drosophila</i> at the heart of fundamental and applied cardiac research.
format	article
author	Anissa Souidi Krzysztof Jagla
author_facet	Anissa Souidi Krzysztof Jagla
author_sort	Anissa Souidi
title	<i>Drosophila</i> Heart as a Model for Cardiac Development and Diseases
title_short	<i>Drosophila</i> Heart as a Model for Cardiac Development and Diseases
title_full	<i>Drosophila</i> Heart as a Model for Cardiac Development and Diseases
title_fullStr	<i>Drosophila</i> Heart as a Model for Cardiac Development and Diseases
title_full_unstemmed	<i>Drosophila</i> Heart as a Model for Cardiac Development and Diseases
title_sort	<i>drosophila</i> heart as a model for cardiac development and diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d35c9e9f2b5d45ba801f697b16baae6e
work_keys_str_mv	AT anissasouidi idrosophilaiheartasamodelforcardiacdevelopmentanddiseases AT krzysztofjagla idrosophilaiheartasamodelforcardiacdevelopmentanddiseases
_version_	1718412680882028544

<i>Drosophila</i> Heart as a Model for Cardiac Development and Diseases

Ejemplares similares