The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner

Isolation of circulating tumor cells (CTCs) allows for non-invasive disease monitoring and characterization. Here the authors describe an alternative CTC isolation method based on the ability of the malaria rVAR2 protein to specifically bind oncofetal chondroitin sulfate, which is expressed by all c...

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Autores principales:	Mette Ø. Agerbæk, Sara R. Bang-Christensen, Ming-Hsin Yang, Thomas M. Clausen, Marina A. Pereira, Shreya Sharma, Sisse B. Ditlev, Morten A. Nielsen, Swati Choudhary, Tobias Gustavsson, Poul H. Sorensen, Tim Meyer, David Propper, Jonathan Shamash, Thor G. Theander, Alexandra Aicher, Mads Daugaard, Christopher Heeschen, Ali Salanti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d35e924f66fe4e69b0fc7725f51ae674
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spelling	oai:doaj.org-article:d35e924f66fe4e69b0fc7725f51ae6742021-12-02T17:32:18ZThe VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner10.1038/s41467-018-05793-22041-1723https://doaj.org/article/d35e924f66fe4e69b0fc7725f51ae6742018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05793-2https://doaj.org/toc/2041-1723Isolation of circulating tumor cells (CTCs) allows for non-invasive disease monitoring and characterization. Here the authors describe an alternative CTC isolation method based on the ability of the malaria rVAR2 protein to specifically bind oncofetal chondroitin sulfate, which is expressed by all cancer cellsMette Ø. AgerbækSara R. Bang-ChristensenMing-Hsin YangThomas M. ClausenMarina A. PereiraShreya SharmaSisse B. DitlevMorten A. NielsenSwati ChoudharyTobias GustavssonPoul H. SorensenTim MeyerDavid PropperJonathan ShamashThor G. TheanderAlexandra AicherMads DaugaardChristopher HeeschenAli SalantiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mette Ø. Agerbæk Sara R. Bang-Christensen Ming-Hsin Yang Thomas M. Clausen Marina A. Pereira Shreya Sharma Sisse B. Ditlev Morten A. Nielsen Swati Choudhary Tobias Gustavsson Poul H. Sorensen Tim Meyer David Propper Jonathan Shamash Thor G. Theander Alexandra Aicher Mads Daugaard Christopher Heeschen Ali Salanti The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
description	Isolation of circulating tumor cells (CTCs) allows for non-invasive disease monitoring and characterization. Here the authors describe an alternative CTC isolation method based on the ability of the malaria rVAR2 protein to specifically bind oncofetal chondroitin sulfate, which is expressed by all cancer cells
format	article
author	Mette Ø. Agerbæk Sara R. Bang-Christensen Ming-Hsin Yang Thomas M. Clausen Marina A. Pereira Shreya Sharma Sisse B. Ditlev Morten A. Nielsen Swati Choudhary Tobias Gustavsson Poul H. Sorensen Tim Meyer David Propper Jonathan Shamash Thor G. Theander Alexandra Aicher Mads Daugaard Christopher Heeschen Ali Salanti
author_facet	Mette Ø. Agerbæk Sara R. Bang-Christensen Ming-Hsin Yang Thomas M. Clausen Marina A. Pereira Shreya Sharma Sisse B. Ditlev Morten A. Nielsen Swati Choudhary Tobias Gustavsson Poul H. Sorensen Tim Meyer David Propper Jonathan Shamash Thor G. Theander Alexandra Aicher Mads Daugaard Christopher Heeschen Ali Salanti
author_sort	Mette Ø. Agerbæk
title	The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
title_short	The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
title_full	The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
title_fullStr	The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
title_full_unstemmed	The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
title_sort	var2csa malaria protein efficiently retrieves circulating tumor cells in an epcam-independent manner
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d35e924f66fe4e69b0fc7725f51ae674
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The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner

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