IMMUNE PARAMETERS IN PATIENTS WITH BREAST CANCER AFTER RADIOTHERAPY AND SURGICAL TREATMENT

Abstract. Some immune parameters (cell subsets in peripheral blood, spontaneous and LPS-induce production of IL-1β, IL-5, IL-7, IL-12, IL-13, IL-17, G-CSF, MCP-1 and MIP-1β in whole blood cultures) were studied in fifty patients with breast cancer (T2-3, N0-3, M0) after radiation therapy and surgica...

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Autores principales:	Yu. B. Selikhova, I. B. Ostanina, N. M. Starostina, S. V. Sidorov, E. V. Menyaeva, V. S. Kozhevnikov, E. R. Chernykh, A. A. Ostanin, V. A. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	breast cancer cytokines il-7 lymphopenia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d36068c491a344fdbd312f14988badc3
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spelling	oai:doaj.org-article:d36068c491a344fdbd312f14988badc32021-11-18T08:03:39ZIMMUNE PARAMETERS IN PATIENTS WITH BREAST CANCER AFTER RADIOTHERAPY AND SURGICAL TREATMENT1563-06252313-741X10.15789/1563-0625-2007-4-5-418-428https://doaj.org/article/d36068c491a344fdbd312f14988badc32014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/197https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Some immune parameters (cell subsets in peripheral blood, spontaneous and LPS-induce production of IL-1β, IL-5, IL-7, IL-12, IL-13, IL-17, G-CSF, MCP-1 and MIP-1β in whole blood cultures) were studied in fifty patients with breast cancer (T2-3, N0-3, M0) after radiation therapy and surgical treatment. A significant decrease in lymphocytes, CD3+ and CD4+T-cell counts, CD19+B-lymphocytes, erythrocytes, hemoglobin level, and amounts of phagocytic cells was revealed. The cytokine status was characterized by prevalence of pro-inflammatory cytokines (IL-1β, IL-12, IL-17) and chemokines (MCP-1, MIP-1β), accompanied by low levels of Th2/ anti-inflammatory IL-13. Furthermore, a markedly increased production of G-CSF and IL-7 was found, thus apparently pointing to the switching of a compensatory mechanisms in response to cytoreductive effects of anti-tumor therapy. IL-7 levels in lymphopenic patients (< 1.2 х 109/L; a mean of 0.81±0.11) were significantly higher than that in an opposite group of lymphopenia-free women (> 1.2 х 109/L; a mean of 1.34±0.01). An inverse correlation (rS = –0,88; p < 0,0001) between blood lymphocyte counts and IL-7 levels allows us to suggest a mechanism of homeostatic peripheral expansion (HPE) to be involved in maintenance and restoration ofT cell homeostasis in the patients treated for breast cancer. Significance of HPE mechanism for induction of both beneficial protective tumor-specific autoimmunity and increased risk of autoimmune complications is discussed.Yu. B. SelikhovaI. B. OstaninaN. M. StarostinaS. V. SidorovE. V. MenyaevaV. S. KozhevnikovE. R. ChernykhA. A. OstaninV. A. KozlovSPb RAACIarticlebreast cancercytokinesil-7lymphopeniaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 4-5, Pp 418-428 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	breast cancer cytokines il-7 lymphopenia Immunologic diseases. Allergy RC581-607
spellingShingle	breast cancer cytokines il-7 lymphopenia Immunologic diseases. Allergy RC581-607 Yu. B. Selikhova I. B. Ostanina N. M. Starostina S. V. Sidorov E. V. Menyaeva V. S. Kozhevnikov E. R. Chernykh A. A. Ostanin V. A. Kozlov IMMUNE PARAMETERS IN PATIENTS WITH BREAST CANCER AFTER RADIOTHERAPY AND SURGICAL TREATMENT
description	Abstract. Some immune parameters (cell subsets in peripheral blood, spontaneous and LPS-induce production of IL-1β, IL-5, IL-7, IL-12, IL-13, IL-17, G-CSF, MCP-1 and MIP-1β in whole blood cultures) were studied in fifty patients with breast cancer (T2-3, N0-3, M0) after radiation therapy and surgical treatment. A significant decrease in lymphocytes, CD3+ and CD4+T-cell counts, CD19+B-lymphocytes, erythrocytes, hemoglobin level, and amounts of phagocytic cells was revealed. The cytokine status was characterized by prevalence of pro-inflammatory cytokines (IL-1β, IL-12, IL-17) and chemokines (MCP-1, MIP-1β), accompanied by low levels of Th2/ anti-inflammatory IL-13. Furthermore, a markedly increased production of G-CSF and IL-7 was found, thus apparently pointing to the switching of a compensatory mechanisms in response to cytoreductive effects of anti-tumor therapy. IL-7 levels in lymphopenic patients (< 1.2 х 109/L; a mean of 0.81±0.11) were significantly higher than that in an opposite group of lymphopenia-free women (> 1.2 х 109/L; a mean of 1.34±0.01). An inverse correlation (rS = –0,88; p < 0,0001) between blood lymphocyte counts and IL-7 levels allows us to suggest a mechanism of homeostatic peripheral expansion (HPE) to be involved in maintenance and restoration ofT cell homeostasis in the patients treated for breast cancer. Significance of HPE mechanism for induction of both beneficial protective tumor-specific autoimmunity and increased risk of autoimmune complications is discussed.
format	article
author	Yu. B. Selikhova I. B. Ostanina N. M. Starostina S. V. Sidorov E. V. Menyaeva V. S. Kozhevnikov E. R. Chernykh A. A. Ostanin V. A. Kozlov
author_facet	Yu. B. Selikhova I. B. Ostanina N. M. Starostina S. V. Sidorov E. V. Menyaeva V. S. Kozhevnikov E. R. Chernykh A. A. Ostanin V. A. Kozlov
author_sort	Yu. B. Selikhova
title	IMMUNE PARAMETERS IN PATIENTS WITH BREAST CANCER AFTER RADIOTHERAPY AND SURGICAL TREATMENT
title_short	IMMUNE PARAMETERS IN PATIENTS WITH BREAST CANCER AFTER RADIOTHERAPY AND SURGICAL TREATMENT
title_full	IMMUNE PARAMETERS IN PATIENTS WITH BREAST CANCER AFTER RADIOTHERAPY AND SURGICAL TREATMENT
title_fullStr	IMMUNE PARAMETERS IN PATIENTS WITH BREAST CANCER AFTER RADIOTHERAPY AND SURGICAL TREATMENT
title_full_unstemmed	IMMUNE PARAMETERS IN PATIENTS WITH BREAST CANCER AFTER RADIOTHERAPY AND SURGICAL TREATMENT
title_sort	immune parameters in patients with breast cancer after radiotherapy and surgical treatment
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/d36068c491a344fdbd312f14988badc3
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IMMUNE PARAMETERS IN PATIENTS WITH BREAST CANCER AFTER RADIOTHERAPY AND SURGICAL TREATMENT

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