Durable and controlled depletion of neutrophils in mice

Anti-Ly6G or ant-Gr1 antibodies are commonly used to deplete neutrophils in vivo. Here the authors provide mechanistic insight into why these approaches may not specifically or durably reduce the number of neutrophils in mice, and also present a new method that overcomes these limitations to have po...

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Autores principales:	Gael Boivin, Julien Faget, Pierre-Benoit Ancey, Aspasia Gkasti, Julie Mussard, Camilla Engblom, Christina Pfirschke, Caroline Contat, Justine Pascual, Jessica Vazquez, Nathalie Bendriss-Vermare, Christophe Caux, Marie-Catherine Vozenin, Mikael J. Pittet, Matthias Gunzer, Etienne Meylan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d3653b7e42a14239a9541459d01f0ce4
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spelling	oai:doaj.org-article:d3653b7e42a14239a9541459d01f0ce42021-12-02T15:57:09ZDurable and controlled depletion of neutrophils in mice10.1038/s41467-020-16596-92041-1723https://doaj.org/article/d3653b7e42a14239a9541459d01f0ce42020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16596-9https://doaj.org/toc/2041-1723Anti-Ly6G or ant-Gr1 antibodies are commonly used to deplete neutrophils in vivo. Here the authors provide mechanistic insight into why these approaches may not specifically or durably reduce the number of neutrophils in mice, and also present a new method that overcomes these limitations to have potentially wide applicability in experimental studies.Gael BoivinJulien FagetPierre-Benoit AnceyAspasia GkastiJulie MussardCamilla EngblomChristina PfirschkeCaroline ContatJustine PascualJessica VazquezNathalie Bendriss-VermareChristophe CauxMarie-Catherine VozeninMikael J. PittetMatthias GunzerEtienne MeylanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gael Boivin Julien Faget Pierre-Benoit Ancey Aspasia Gkasti Julie Mussard Camilla Engblom Christina Pfirschke Caroline Contat Justine Pascual Jessica Vazquez Nathalie Bendriss-Vermare Christophe Caux Marie-Catherine Vozenin Mikael J. Pittet Matthias Gunzer Etienne Meylan Durable and controlled depletion of neutrophils in mice
description	Anti-Ly6G or ant-Gr1 antibodies are commonly used to deplete neutrophils in vivo. Here the authors provide mechanistic insight into why these approaches may not specifically or durably reduce the number of neutrophils in mice, and also present a new method that overcomes these limitations to have potentially wide applicability in experimental studies.
format	article
author	Gael Boivin Julien Faget Pierre-Benoit Ancey Aspasia Gkasti Julie Mussard Camilla Engblom Christina Pfirschke Caroline Contat Justine Pascual Jessica Vazquez Nathalie Bendriss-Vermare Christophe Caux Marie-Catherine Vozenin Mikael J. Pittet Matthias Gunzer Etienne Meylan
author_facet	Gael Boivin Julien Faget Pierre-Benoit Ancey Aspasia Gkasti Julie Mussard Camilla Engblom Christina Pfirschke Caroline Contat Justine Pascual Jessica Vazquez Nathalie Bendriss-Vermare Christophe Caux Marie-Catherine Vozenin Mikael J. Pittet Matthias Gunzer Etienne Meylan
author_sort	Gael Boivin
title	Durable and controlled depletion of neutrophils in mice
title_short	Durable and controlled depletion of neutrophils in mice
title_full	Durable and controlled depletion of neutrophils in mice
title_fullStr	Durable and controlled depletion of neutrophils in mice
title_full_unstemmed	Durable and controlled depletion of neutrophils in mice
title_sort	durable and controlled depletion of neutrophils in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d3653b7e42a14239a9541459d01f0ce4
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_version_	1718385360048750592

Durable and controlled depletion of neutrophils in mice

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