Predicting flows through microfluidic circuits with fluid walls

Abstract The aqueous phase in traditional microfluidics is usually confined by solid walls; flows through such systems are often predicted accurately. As solid walls limit access, open systems are being developed in which the aqueous phase is partly bounded by fluid walls (interfaces with air or imm...

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Autores principales:	Cyril Deroy, Nicholas Stovall-Kurtz, Federico Nebuloni, Cristian Soitu, Peter R. Cook, Edmond J. Walsh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Technology T Engineering (General). Civil engineering (General) TA1-2040
Acceso en línea:	https://doaj.org/article/d365742491654808a50d05682003a993
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spelling	oai:doaj.org-article:d365742491654808a50d05682003a9932021-11-21T12:06:30ZPredicting flows through microfluidic circuits with fluid walls10.1038/s41378-021-00322-62055-7434https://doaj.org/article/d365742491654808a50d05682003a9932021-11-01T00:00:00Zhttps://doi.org/10.1038/s41378-021-00322-6https://doaj.org/toc/2055-7434Abstract The aqueous phase in traditional microfluidics is usually confined by solid walls; flows through such systems are often predicted accurately. As solid walls limit access, open systems are being developed in which the aqueous phase is partly bounded by fluid walls (interfaces with air or immiscible liquids). Such fluid walls morph during flow due to pressure gradients, so predicting flow fields remains challenging. We recently developed a version of open microfluidics suitable for live-cell biology in which the aqueous phase is confined by an interface with an immiscible and bioinert fluorocarbon (FC40). Here, we find that common medium additives (fetal bovine serum, serum replacement) induce elastic no-slip boundaries at this interface and develop a semi-analytical model to predict flow fields. We experimentally validate the model’s accuracy for single conduits and fractal vascular trees and demonstrate how flow fields and shear stresses can be controlled to suit individual applications in cell biology.Cyril DeroyNicholas Stovall-KurtzFederico NebuloniCristian SoituPeter R. CookEdmond J. WalshNature Publishing GrouparticleTechnologyTEngineering (General). Civil engineering (General)TA1-2040ENMicrosystems & Nanoengineering, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Technology T Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	Technology T Engineering (General). Civil engineering (General) TA1-2040 Cyril Deroy Nicholas Stovall-Kurtz Federico Nebuloni Cristian Soitu Peter R. Cook Edmond J. Walsh Predicting flows through microfluidic circuits with fluid walls
description	Abstract The aqueous phase in traditional microfluidics is usually confined by solid walls; flows through such systems are often predicted accurately. As solid walls limit access, open systems are being developed in which the aqueous phase is partly bounded by fluid walls (interfaces with air or immiscible liquids). Such fluid walls morph during flow due to pressure gradients, so predicting flow fields remains challenging. We recently developed a version of open microfluidics suitable for live-cell biology in which the aqueous phase is confined by an interface with an immiscible and bioinert fluorocarbon (FC40). Here, we find that common medium additives (fetal bovine serum, serum replacement) induce elastic no-slip boundaries at this interface and develop a semi-analytical model to predict flow fields. We experimentally validate the model’s accuracy for single conduits and fractal vascular trees and demonstrate how flow fields and shear stresses can be controlled to suit individual applications in cell biology.
format	article
author	Cyril Deroy Nicholas Stovall-Kurtz Federico Nebuloni Cristian Soitu Peter R. Cook Edmond J. Walsh
author_facet	Cyril Deroy Nicholas Stovall-Kurtz Federico Nebuloni Cristian Soitu Peter R. Cook Edmond J. Walsh
author_sort	Cyril Deroy
title	Predicting flows through microfluidic circuits with fluid walls
title_short	Predicting flows through microfluidic circuits with fluid walls
title_full	Predicting flows through microfluidic circuits with fluid walls
title_fullStr	Predicting flows through microfluidic circuits with fluid walls
title_full_unstemmed	Predicting flows through microfluidic circuits with fluid walls
title_sort	predicting flows through microfluidic circuits with fluid walls
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/d365742491654808a50d05682003a993
work_keys_str_mv	AT cyrilderoy predictingflowsthroughmicrofluidiccircuitswithfluidwalls AT nicholasstovallkurtz predictingflowsthroughmicrofluidiccircuitswithfluidwalls AT federiconebuloni predictingflowsthroughmicrofluidiccircuitswithfluidwalls AT cristiansoitu predictingflowsthroughmicrofluidiccircuitswithfluidwalls AT peterrcook predictingflowsthroughmicrofluidiccircuitswithfluidwalls AT edmondjwalsh predictingflowsthroughmicrofluidiccircuitswithfluidwalls
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Predicting flows through microfluidic circuits with fluid walls

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