Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis.

Suppression of T cell response is thought to be involved in the pathogenesis of visceral leishmaniasis (VL). Regulatory T cell (Treg) mediated immune-suppression is reported in animal models of Leishmania infection. However, their precise role among human patients still requires pathologic validatio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ambak K Rai, Chandreshwar P Thakur, Amar Singh, Tulika Seth, Sandeep K Srivastava, Pushpendra Singh, Dipendra K Mitra
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d3679d7bf27f41bc898681926d319457
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d3679d7bf27f41bc898681926d319457
record_format	dspace
spelling	oai:doaj.org-article:d3679d7bf27f41bc898681926d3194572021-11-18T07:28:37ZRegulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis.1932-620310.1371/journal.pone.0031551https://doaj.org/article/d3679d7bf27f41bc898681926d3194572012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22347492/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Suppression of T cell response is thought to be involved in the pathogenesis of visceral leishmaniasis (VL). Regulatory T cell (Treg) mediated immune-suppression is reported in animal models of Leishmania infection. However, their precise role among human patients still requires pathologic validation. The present study is aimed at understanding the frequency dynamics and function of Treg cells in the blood and bone marrow (BM) of VL patients. The study included 42 parasitologically confirmed patients, 17 healthy contact and 9 normal bone marrow specimens (NBM). We show i) the selective accumulation of Treg cells at one of the disease inflicted site(s), the BM, ii) their in vitro expansion in response to LD antigen and iii) persistence after successful chemotherapy. Results indicate that the Treg cells isolated from BM produces IL-10 and may inhibit T cell activation in IL-10 dependent manner. Moreover, we observed significantly higher levels of IL-10 among drug unresponsive patients, suggesting their critical role in suppression of immunity among VL patients. Our results suggest that IL-10 plays an important role in suppression of host immunity in human VL and possibly determines the efficacy of chemotherapy.Ambak K RaiChandreshwar P ThakurAmar SinghTulika SethSandeep K SrivastavaPushpendra SinghDipendra K MitraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31551 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ambak K Rai Chandreshwar P Thakur Amar Singh Tulika Seth Sandeep K Srivastava Pushpendra Singh Dipendra K Mitra Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis.
description	Suppression of T cell response is thought to be involved in the pathogenesis of visceral leishmaniasis (VL). Regulatory T cell (Treg) mediated immune-suppression is reported in animal models of Leishmania infection. However, their precise role among human patients still requires pathologic validation. The present study is aimed at understanding the frequency dynamics and function of Treg cells in the blood and bone marrow (BM) of VL patients. The study included 42 parasitologically confirmed patients, 17 healthy contact and 9 normal bone marrow specimens (NBM). We show i) the selective accumulation of Treg cells at one of the disease inflicted site(s), the BM, ii) their in vitro expansion in response to LD antigen and iii) persistence after successful chemotherapy. Results indicate that the Treg cells isolated from BM produces IL-10 and may inhibit T cell activation in IL-10 dependent manner. Moreover, we observed significantly higher levels of IL-10 among drug unresponsive patients, suggesting their critical role in suppression of immunity among VL patients. Our results suggest that IL-10 plays an important role in suppression of host immunity in human VL and possibly determines the efficacy of chemotherapy.
format	article
author	Ambak K Rai Chandreshwar P Thakur Amar Singh Tulika Seth Sandeep K Srivastava Pushpendra Singh Dipendra K Mitra
author_facet	Ambak K Rai Chandreshwar P Thakur Amar Singh Tulika Seth Sandeep K Srivastava Pushpendra Singh Dipendra K Mitra
author_sort	Ambak K Rai
title	Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis.
title_short	Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis.
title_full	Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis.
title_fullStr	Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis.
title_full_unstemmed	Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis.
title_sort	regulatory t cells suppress t cell activation at the pathologic site of human visceral leishmaniasis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/d3679d7bf27f41bc898681926d319457
work_keys_str_mv	AT ambakkrai regulatorytcellssuppresstcellactivationatthepathologicsiteofhumanvisceralleishmaniasis AT chandreshwarpthakur regulatorytcellssuppresstcellactivationatthepathologicsiteofhumanvisceralleishmaniasis AT amarsingh regulatorytcellssuppresstcellactivationatthepathologicsiteofhumanvisceralleishmaniasis AT tulikaseth regulatorytcellssuppresstcellactivationatthepathologicsiteofhumanvisceralleishmaniasis AT sandeepksrivastava regulatorytcellssuppresstcellactivationatthepathologicsiteofhumanvisceralleishmaniasis AT pushpendrasingh regulatorytcellssuppresstcellactivationatthepathologicsiteofhumanvisceralleishmaniasis AT dipendrakmitra regulatorytcellssuppresstcellactivationatthepathologicsiteofhumanvisceralleishmaniasis
_version_	1718423439579021312

Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis.

Ejemplares similares