Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease

Most cases of autosomal dominant polycystic kidney disease (ADPKD) are due to mutations in PKD1. Here, Tsukiyama et al. generate monkeys with mutations in PKD1 and show that animals recapitulate key pathological features of the human disease, suggesting these may provide insights into ADPKD pathogen...

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Autores principales:	Tomoyuki Tsukiyama, Kenichi Kobayashi, Masataka Nakaya, Chizuru Iwatani, Yasunari Seita, Hideaki Tsuchiya, Jun Matsushita, Kahoru Kitajima, Ikuo Kawamoto, Takahiro Nakagawa, Koji Fukuda, Teppei Iwakiri, Hiroyuki Izumi, Iori Itagaki, Shinji Kume, Hiroshi Maegawa, Ryuichi Nishinakamura, Saori Nishio, Shinichiro Nakamura, Akihiro Kawauchi, Masatsugu Ema
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d36be4b757ea428ba412befef7b9ef31
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spelling	oai:doaj.org-article:d36be4b757ea428ba412befef7b9ef312021-12-02T15:36:05ZMonkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease10.1038/s41467-019-13398-62041-1723https://doaj.org/article/d36be4b757ea428ba412befef7b9ef312019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13398-6https://doaj.org/toc/2041-1723Most cases of autosomal dominant polycystic kidney disease (ADPKD) are due to mutations in PKD1. Here, Tsukiyama et al. generate monkeys with mutations in PKD1 and show that animals recapitulate key pathological features of the human disease, suggesting these may provide insights into ADPKD pathogenesis and contribute to the development of future therapeutic strategies.Tomoyuki TsukiyamaKenichi KobayashiMasataka NakayaChizuru IwataniYasunari SeitaHideaki TsuchiyaJun MatsushitaKahoru KitajimaIkuo KawamotoTakahiro NakagawaKoji FukudaTeppei IwakiriHiroyuki IzumiIori ItagakiShinji KumeHiroshi MaegawaRyuichi NishinakamuraSaori NishioShinichiro NakamuraAkihiro KawauchiMasatsugu EmaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomoyuki Tsukiyama Kenichi Kobayashi Masataka Nakaya Chizuru Iwatani Yasunari Seita Hideaki Tsuchiya Jun Matsushita Kahoru Kitajima Ikuo Kawamoto Takahiro Nakagawa Koji Fukuda Teppei Iwakiri Hiroyuki Izumi Iori Itagaki Shinji Kume Hiroshi Maegawa Ryuichi Nishinakamura Saori Nishio Shinichiro Nakamura Akihiro Kawauchi Masatsugu Ema Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
description	Most cases of autosomal dominant polycystic kidney disease (ADPKD) are due to mutations in PKD1. Here, Tsukiyama et al. generate monkeys with mutations in PKD1 and show that animals recapitulate key pathological features of the human disease, suggesting these may provide insights into ADPKD pathogenesis and contribute to the development of future therapeutic strategies.
format	article
author	Tomoyuki Tsukiyama Kenichi Kobayashi Masataka Nakaya Chizuru Iwatani Yasunari Seita Hideaki Tsuchiya Jun Matsushita Kahoru Kitajima Ikuo Kawamoto Takahiro Nakagawa Koji Fukuda Teppei Iwakiri Hiroyuki Izumi Iori Itagaki Shinji Kume Hiroshi Maegawa Ryuichi Nishinakamura Saori Nishio Shinichiro Nakamura Akihiro Kawauchi Masatsugu Ema
author_facet	Tomoyuki Tsukiyama Kenichi Kobayashi Masataka Nakaya Chizuru Iwatani Yasunari Seita Hideaki Tsuchiya Jun Matsushita Kahoru Kitajima Ikuo Kawamoto Takahiro Nakagawa Koji Fukuda Teppei Iwakiri Hiroyuki Izumi Iori Itagaki Shinji Kume Hiroshi Maegawa Ryuichi Nishinakamura Saori Nishio Shinichiro Nakamura Akihiro Kawauchi Masatsugu Ema
author_sort	Tomoyuki Tsukiyama
title	Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
title_short	Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
title_full	Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
title_fullStr	Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
title_full_unstemmed	Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
title_sort	monkeys mutant for pkd1 recapitulate human autosomal dominant polycystic kidney disease
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d36be4b757ea428ba412befef7b9ef31
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Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease

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