A brief review on the mode of action of antinematodal drugs

Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites. Included are the older classes of compounds; the benzimidazoles, cholinergic agonists and macrocyclic lactones. We also consider newer anthelm...

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Autores principales:	Abongwa Melanie, Martin Richard J., Robertson Alan P.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2017
Materias:	anthelmintic parasite benzimidazoles avermectins cholinergic emodepside derquantel Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/d36ccaf5e1ab413da80f4974cc29da98
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id	oai:doaj.org-article:d36ccaf5e1ab413da80f4974cc29da98
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spelling	oai:doaj.org-article:d36ccaf5e1ab413da80f4974cc29da982021-11-17T21:27:51ZA brief review on the mode of action of antinematodal drugs1820-744810.1515/acve-2017-0013https://doaj.org/article/d36ccaf5e1ab413da80f4974cc29da982017-06-01T00:00:00Zhttps://doi.org/10.1515/acve-2017-0013https://doaj.org/toc/1820-7448Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites. Included are the older classes of compounds; the benzimidazoles, cholinergic agonists and macrocyclic lactones. We also consider newer anthelmintics, including emodepside, derquantel and tribendimidine. In the absence of vaccines for most parasite species, control of nematode parasites will continue to rely on anthelmintic drugs. As a consequence, vigilance in detecting drug resistance in parasite populations is required. Since resistance development appears almost inevitable, there is a continued and pressing need to fully understand the mode of action of these compounds. It is also necessary to identify new drug targets and drugs for the continued effective control of nematode parasites.Abongwa MelanieMartin Richard J.Robertson Alan P.SciendoarticleanthelminticparasitebenzimidazolesavermectinscholinergicemodepsidederquantelVeterinary medicineSF600-1100ENActa Veterinaria, Vol 67, Iss 2, Pp 137-152 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	anthelmintic parasite benzimidazoles avermectins cholinergic emodepside derquantel Veterinary medicine SF600-1100
spellingShingle	anthelmintic parasite benzimidazoles avermectins cholinergic emodepside derquantel Veterinary medicine SF600-1100 Abongwa Melanie Martin Richard J. Robertson Alan P. A brief review on the mode of action of antinematodal drugs
description	Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites. Included are the older classes of compounds; the benzimidazoles, cholinergic agonists and macrocyclic lactones. We also consider newer anthelmintics, including emodepside, derquantel and tribendimidine. In the absence of vaccines for most parasite species, control of nematode parasites will continue to rely on anthelmintic drugs. As a consequence, vigilance in detecting drug resistance in parasite populations is required. Since resistance development appears almost inevitable, there is a continued and pressing need to fully understand the mode of action of these compounds. It is also necessary to identify new drug targets and drugs for the continued effective control of nematode parasites.
format	article
author	Abongwa Melanie Martin Richard J. Robertson Alan P.
author_facet	Abongwa Melanie Martin Richard J. Robertson Alan P.
author_sort	Abongwa Melanie
title	A brief review on the mode of action of antinematodal drugs
title_short	A brief review on the mode of action of antinematodal drugs
title_full	A brief review on the mode of action of antinematodal drugs
title_fullStr	A brief review on the mode of action of antinematodal drugs
title_full_unstemmed	A brief review on the mode of action of antinematodal drugs
title_sort	brief review on the mode of action of antinematodal drugs
publisher	Sciendo
publishDate	2017
url	https://doaj.org/article/d36ccaf5e1ab413da80f4974cc29da98
work_keys_str_mv	AT abongwamelanie abriefreviewonthemodeofactionofantinematodaldrugs AT martinrichardj abriefreviewonthemodeofactionofantinematodaldrugs AT robertsonalanp abriefreviewonthemodeofactionofantinematodaldrugs AT abongwamelanie briefreviewonthemodeofactionofantinematodaldrugs AT martinrichardj briefreviewonthemodeofactionofantinematodaldrugs AT robertsonalanp briefreviewonthemodeofactionofantinematodaldrugs
_version_	1718425319634894848

A brief review on the mode of action of antinematodal drugs

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