Role of SatO2, PaO2/FiO2 Ratio and PaO2 to Predict Adverse Outcome in COVID-19: A Retrospective, Cohort Study

COVID-19 respiratory failure is a life-threatening condition. Oxygenation targets were evaluated in a non-ICU setting. In this retrospective, observational study, we enrolled all patients admitted to the University Hospital of Genoa, Italy, between 1 February and 31 May 2020 with an RT-PCR positive...

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Autores principales:	Stefano Sartini, Laura Massobrio, Ombretta Cutuli, Paola Campodonico, Cristina Bernini, Marina Sartini, Maria Luisa Cristina, Luca Castellani, Ludovica Ceschi, Marzia Spadaro, Angelo Gratarola, Paolo Barbera
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 respiratory failure hyperoxia hypoxia non-invasive ventilation Medicine R
Acceso en línea:	https://doaj.org/article/d36fba1ca27f4d1e869ad85bc453bea2
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spelling	oai:doaj.org-article:d36fba1ca27f4d1e869ad85bc453bea22021-11-11T16:38:56ZRole of SatO2, PaO2/FiO2 Ratio and PaO2 to Predict Adverse Outcome in COVID-19: A Retrospective, Cohort Study10.3390/ijerph1821115341660-46011661-7827https://doaj.org/article/d36fba1ca27f4d1e869ad85bc453bea22021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11534https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601COVID-19 respiratory failure is a life-threatening condition. Oxygenation targets were evaluated in a non-ICU setting. In this retrospective, observational study, we enrolled all patients admitted to the University Hospital of Genoa, Italy, between 1 February and 31 May 2020 with an RT-PCR positive for SARS-CoV-2. PaO2, PaO2/FiO2 and SatO2% were collected and analyzed at time 0 and in case of admission, patients who required or not C-PAP (groups A and B) were categorized. Each measurement was correlated to adverse outcome. A total of 483 patients were enrolled, and 369 were admitted to hospital. Of these, 153 required C-PAP and 266 had an adverse outcome. Patients with PaO2 <60 and >100 had a higher rate of adverse outcome at time 0, in groups A and B (OR 2.52, 3.45, 2.01, respectively). About the PaO2/FiO2 ratio, the OR for < 300 was 3.10 at time 0, 4.01 in group A and 4.79 in group B. Similar odds were found for < 200 in any groups and < 100 except for group B (OR 11.57). SatO2 < 94% showed OR 1.34, 3.52 and 19.12 at time 0, in groups A and B, respectively. PaO2 < 60 and >100, SatO2 < 94% and PaO2/FiO2 ratio < 300 showed at least two- to three-fold correlation to adverse outcome. This may provide simple but clear targets for clinicians facing COVID-19 respiratory failure in a non ICU-setting.Stefano SartiniLaura MassobrioOmbretta CutuliPaola CampodonicoCristina BerniniMarina SartiniMaria Luisa CristinaLuca CastellaniLudovica CeschiMarzia SpadaroAngelo GratarolaPaolo BarberaMDPI AGarticleCOVID-19respiratory failurehyperoxiahypoxianon-invasive ventilationMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11534, p 11534 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 respiratory failure hyperoxia hypoxia non-invasive ventilation Medicine R
spellingShingle	COVID-19 respiratory failure hyperoxia hypoxia non-invasive ventilation Medicine R Stefano Sartini Laura Massobrio Ombretta Cutuli Paola Campodonico Cristina Bernini Marina Sartini Maria Luisa Cristina Luca Castellani Ludovica Ceschi Marzia Spadaro Angelo Gratarola Paolo Barbera Role of SatO2, PaO2/FiO2 Ratio and PaO2 to Predict Adverse Outcome in COVID-19: A Retrospective, Cohort Study
description	COVID-19 respiratory failure is a life-threatening condition. Oxygenation targets were evaluated in a non-ICU setting. In this retrospective, observational study, we enrolled all patients admitted to the University Hospital of Genoa, Italy, between 1 February and 31 May 2020 with an RT-PCR positive for SARS-CoV-2. PaO2, PaO2/FiO2 and SatO2% were collected and analyzed at time 0 and in case of admission, patients who required or not C-PAP (groups A and B) were categorized. Each measurement was correlated to adverse outcome. A total of 483 patients were enrolled, and 369 were admitted to hospital. Of these, 153 required C-PAP and 266 had an adverse outcome. Patients with PaO2 <60 and >100 had a higher rate of adverse outcome at time 0, in groups A and B (OR 2.52, 3.45, 2.01, respectively). About the PaO2/FiO2 ratio, the OR for < 300 was 3.10 at time 0, 4.01 in group A and 4.79 in group B. Similar odds were found for < 200 in any groups and < 100 except for group B (OR 11.57). SatO2 < 94% showed OR 1.34, 3.52 and 19.12 at time 0, in groups A and B, respectively. PaO2 < 60 and >100, SatO2 < 94% and PaO2/FiO2 ratio < 300 showed at least two- to three-fold correlation to adverse outcome. This may provide simple but clear targets for clinicians facing COVID-19 respiratory failure in a non ICU-setting.
format	article
author	Stefano Sartini Laura Massobrio Ombretta Cutuli Paola Campodonico Cristina Bernini Marina Sartini Maria Luisa Cristina Luca Castellani Ludovica Ceschi Marzia Spadaro Angelo Gratarola Paolo Barbera
author_facet	Stefano Sartini Laura Massobrio Ombretta Cutuli Paola Campodonico Cristina Bernini Marina Sartini Maria Luisa Cristina Luca Castellani Ludovica Ceschi Marzia Spadaro Angelo Gratarola Paolo Barbera
author_sort	Stefano Sartini
title	Role of SatO2, PaO2/FiO2 Ratio and PaO2 to Predict Adverse Outcome in COVID-19: A Retrospective, Cohort Study
title_short	Role of SatO2, PaO2/FiO2 Ratio and PaO2 to Predict Adverse Outcome in COVID-19: A Retrospective, Cohort Study
title_full	Role of SatO2, PaO2/FiO2 Ratio and PaO2 to Predict Adverse Outcome in COVID-19: A Retrospective, Cohort Study
title_fullStr	Role of SatO2, PaO2/FiO2 Ratio and PaO2 to Predict Adverse Outcome in COVID-19: A Retrospective, Cohort Study
title_full_unstemmed	Role of SatO2, PaO2/FiO2 Ratio and PaO2 to Predict Adverse Outcome in COVID-19: A Retrospective, Cohort Study
title_sort	role of sato2, pao2/fio2 ratio and pao2 to predict adverse outcome in covid-19: a retrospective, cohort study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d36fba1ca27f4d1e869ad85bc453bea2
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Role of SatO2, PaO2/FiO2 Ratio and PaO2 to Predict Adverse Outcome in COVID-19: A Retrospective, Cohort Study

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