Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography

Yukinori Sugano, Tetsuju Sekiryu, Minoru Furuta, Ryutaro Tomita, Hiroaki Shintake, Hiroki Maehara, Akira Ojima Department of Ophthalmology, Fukushima Medical University, Fukushima, Japan Purpose: To assess the reproducibility of quantitative morphometrical evaluation of the choriocapillaris imaged...

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Autores principales:	Sugano Y, Sekiryu T, Furuta M, Tomita R, Shintake H, Maehara H, Ojima A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	choriocapillaris swept source optical coherence tomography angiography morphometry vessel density Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/d370f46d86554fe2a7fffee9a7bfb203
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spelling	oai:doaj.org-article:d370f46d86554fe2a7fffee9a7bfb2032021-12-02T03:20:34ZMorphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography1177-5483https://doaj.org/article/d370f46d86554fe2a7fffee9a7bfb2032018-11-01T00:00:00Zhttps://www.dovepress.com/morphometrical-evaluation-of-the-choriocapillaris-imaged-by-swept-sour-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Yukinori Sugano, Tetsuju Sekiryu, Minoru Furuta, Ryutaro Tomita, Hiroaki Shintake, Hiroki Maehara, Akira Ojima Department of Ophthalmology, Fukushima Medical University, Fukushima, Japan Purpose: To assess the reproducibility of quantitative morphometrical evaluation of the choriocapillaris imaged with swept-source optical coherence tomography angiography (SS-OCTA).Subjects and methods: This observational, cross-sectional case series included 35 eyes of healthy individuals and 32 eyes of 32 patients. Two images of the fovea were taken using SS-OCTA with 3×3 mm squares. Images of the choriocapillaris within 800×800 pixel squares centered at the fovea were analyzed morphometrically using open-source software “AngioTool” that applies a Gaussian recursive filter and multiscale Hessian enhancement. This program’s vessel thickness and intensity parameters can be changed to aid vessel detection. We measured the pairs of images per eye with different parameter sets and calculated the intraclass correlation (ICC) for the morphometrical results. After determining the parameters that produced high reproducibility, we evaluated regional variations in 800×800 pixel mm squares within the fovea.Results: The ICCs for vessel area, total vessel length, vessel diameter index, and mean lacunarity were over 0.9 using the parameters of “vessel thickness” 3–4 and intensity 15 in the group including all subjects. When measurements were performed using these same parameter values, the vessel density and mean vessel diameter index were 60.5% and 19.1±0.389, respectively. Vessel density, vessel length, vessel diameter index, and mean lacunarity did not change significantly within an 800×800 pixel square centered at the fovea except for the 200×200 pixel square at the foveal center.Conclusion: SS-OCTA images of the choriocapillaris can be measured with high reproducibility by morphometrical evaluation using open-source software with multiscale Hessian enhancement. Such automated morphometric analysis can provide an objective evaluation of the choriocapillaris. Keywords: choriocapillaris, swept-source optical coherence tomography angiography, morphometry, vessel densitySugano YSekiryu TFuruta MTomita RShintake HMaehara HOjima ADove Medical Pressarticlechoriocapillarisswept source optical coherence tomography angiographymorphometryvessel densityOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 2267-2276 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	choriocapillaris swept source optical coherence tomography angiography morphometry vessel density Ophthalmology RE1-994
spellingShingle	choriocapillaris swept source optical coherence tomography angiography morphometry vessel density Ophthalmology RE1-994 Sugano Y Sekiryu T Furuta M Tomita R Shintake H Maehara H Ojima A Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography
description	Yukinori Sugano, Tetsuju Sekiryu, Minoru Furuta, Ryutaro Tomita, Hiroaki Shintake, Hiroki Maehara, Akira Ojima Department of Ophthalmology, Fukushima Medical University, Fukushima, Japan Purpose: To assess the reproducibility of quantitative morphometrical evaluation of the choriocapillaris imaged with swept-source optical coherence tomography angiography (SS-OCTA).Subjects and methods: This observational, cross-sectional case series included 35 eyes of healthy individuals and 32 eyes of 32 patients. Two images of the fovea were taken using SS-OCTA with 3×3 mm squares. Images of the choriocapillaris within 800×800 pixel squares centered at the fovea were analyzed morphometrically using open-source software “AngioTool” that applies a Gaussian recursive filter and multiscale Hessian enhancement. This program’s vessel thickness and intensity parameters can be changed to aid vessel detection. We measured the pairs of images per eye with different parameter sets and calculated the intraclass correlation (ICC) for the morphometrical results. After determining the parameters that produced high reproducibility, we evaluated regional variations in 800×800 pixel mm squares within the fovea.Results: The ICCs for vessel area, total vessel length, vessel diameter index, and mean lacunarity were over 0.9 using the parameters of “vessel thickness” 3–4 and intensity 15 in the group including all subjects. When measurements were performed using these same parameter values, the vessel density and mean vessel diameter index were 60.5% and 19.1±0.389, respectively. Vessel density, vessel length, vessel diameter index, and mean lacunarity did not change significantly within an 800×800 pixel square centered at the fovea except for the 200×200 pixel square at the foveal center.Conclusion: SS-OCTA images of the choriocapillaris can be measured with high reproducibility by morphometrical evaluation using open-source software with multiscale Hessian enhancement. Such automated morphometric analysis can provide an objective evaluation of the choriocapillaris. Keywords: choriocapillaris, swept-source optical coherence tomography angiography, morphometry, vessel density
format	article
author	Sugano Y Sekiryu T Furuta M Tomita R Shintake H Maehara H Ojima A
author_facet	Sugano Y Sekiryu T Furuta M Tomita R Shintake H Maehara H Ojima A
author_sort	Sugano Y
title	Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography
title_short	Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography
title_full	Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography
title_fullStr	Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography
title_full_unstemmed	Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography
title_sort	morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d370f46d86554fe2a7fffee9a7bfb203
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Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography

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