The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy

Lung cancer patients who smoke show a better response to immunotherapy than non-smokers. Here, the authors show that tobacco smoke induces PD-L1 expression on lung epithelial cells via AhR that is associated with benefits of PD-1 inhibitor in patients, shedding new lights on lung carcinogenesis and...

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Autores principales:	Gui-Zhen Wang, Li Zhang, Xin-Chun Zhao, San-Hui Gao, Li-Wei Qu, Hong Yu, Wen-Feng Fang, Yong-Chun Zhou, Fan Liang, Chen Zhang, Yun-Chao Huang, Zhihua Liu, Yang-Xin Fu, Guang-Biao Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d371cb011e6b4efbb2eef8fc2a22dd28
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spelling	oai:doaj.org-article:d371cb011e6b4efbb2eef8fc2a22dd282021-12-02T15:35:52ZThe Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy10.1038/s41467-019-08887-72041-1723https://doaj.org/article/d371cb011e6b4efbb2eef8fc2a22dd282019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08887-7https://doaj.org/toc/2041-1723Lung cancer patients who smoke show a better response to immunotherapy than non-smokers. Here, the authors show that tobacco smoke induces PD-L1 expression on lung epithelial cells via AhR that is associated with benefits of PD-1 inhibitor in patients, shedding new lights on lung carcinogenesis and immunotherapy.Gui-Zhen WangLi ZhangXin-Chun ZhaoSan-Hui GaoLi-Wei QuHong YuWen-Feng FangYong-Chun ZhouFan LiangChen ZhangYun-Chao HuangZhihua LiuYang-Xin FuGuang-Biao ZhouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gui-Zhen Wang Li Zhang Xin-Chun Zhao San-Hui Gao Li-Wei Qu Hong Yu Wen-Feng Fang Yong-Chun Zhou Fan Liang Chen Zhang Yun-Chao Huang Zhihua Liu Yang-Xin Fu Guang-Biao Zhou The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy
description	Lung cancer patients who smoke show a better response to immunotherapy than non-smokers. Here, the authors show that tobacco smoke induces PD-L1 expression on lung epithelial cells via AhR that is associated with benefits of PD-1 inhibitor in patients, shedding new lights on lung carcinogenesis and immunotherapy.
format	article
author	Gui-Zhen Wang Li Zhang Xin-Chun Zhao San-Hui Gao Li-Wei Qu Hong Yu Wen-Feng Fang Yong-Chun Zhou Fan Liang Chen Zhang Yun-Chao Huang Zhihua Liu Yang-Xin Fu Guang-Biao Zhou
author_facet	Gui-Zhen Wang Li Zhang Xin-Chun Zhao San-Hui Gao Li-Wei Qu Hong Yu Wen-Feng Fang Yong-Chun Zhou Fan Liang Chen Zhang Yun-Chao Huang Zhihua Liu Yang-Xin Fu Guang-Biao Zhou
author_sort	Gui-Zhen Wang
title	The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy
title_short	The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy
title_full	The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy
title_fullStr	The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy
title_full_unstemmed	The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy
title_sort	aryl hydrocarbon receptor mediates tobacco-induced pd-l1 expression and is associated with response to immunotherapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d371cb011e6b4efbb2eef8fc2a22dd28
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The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy

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