The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy
Lung cancer patients who smoke show a better response to immunotherapy than non-smokers. Here, the authors show that tobacco smoke induces PD-L1 expression on lung epithelial cells via AhR that is associated with benefits of PD-1 inhibitor in patients, shedding new lights on lung carcinogenesis and...
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Autores principales: | Gui-Zhen Wang, Li Zhang, Xin-Chun Zhao, San-Hui Gao, Li-Wei Qu, Hong Yu, Wen-Feng Fang, Yong-Chun Zhou, Fan Liang, Chen Zhang, Yun-Chao Huang, Zhihua Liu, Yang-Xin Fu, Guang-Biao Zhou |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/d371cb011e6b4efbb2eef8fc2a22dd28 |
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