In vivo demonstration of a novel non-invasive model for inducing localized hypothermia to ameliorate hepatotoxicity

Abstract Moderate hypothermia (32 °C) has been previously shown to ameliorate drug-induced liver injuries in vitro. However, there are concerns regarding its clinical relevance as it remains a challenge to perform selective liver cooling in a non-invasive manner. To reconcile this dilemma, we propos...

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Autores principales:	Yeong Lan Tan, Min En Nga, Han Kiat Ho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d3730dcb0cf048a1bedb4709e89923ea
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spelling	oai:doaj.org-article:d3730dcb0cf048a1bedb4709e89923ea2021-12-02T17:26:49ZIn vivo demonstration of a novel non-invasive model for inducing localized hypothermia to ameliorate hepatotoxicity10.1038/s41598-021-98078-62045-2322https://doaj.org/article/d3730dcb0cf048a1bedb4709e89923ea2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98078-6https://doaj.org/toc/2045-2322Abstract Moderate hypothermia (32 °C) has been previously shown to ameliorate drug-induced liver injuries in vitro. However, there are concerns regarding its clinical relevance as it remains a challenge to perform selective liver cooling in a non-invasive manner. To reconcile this dilemma, we propose the use of pulsed cooling for regional hypothermic conditioning in liver. This involves intermittent cooling applied in pulses of 15 min each, with a one-hour recovery interval between pulses. Cooling is achieved by applying ice packs to the cutaneous region overlying the liver. Through an in vivo C57BL/6NTac mouse study, we demonstrated the feasibility of attaining localized hypothermia close to the liver while maintaining core body temperature. This has successfully ameliorated acetaminophen-induced liver injury based on the liver function tests, liver histology and total weight change. Collectively, we provide a proof of concept for pulsed external localized cooling as being clinically actionable to perform induced selective hypothermia.Yeong Lan TanMin En NgaHan Kiat HoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yeong Lan Tan Min En Nga Han Kiat Ho In vivo demonstration of a novel non-invasive model for inducing localized hypothermia to ameliorate hepatotoxicity
description	Abstract Moderate hypothermia (32 °C) has been previously shown to ameliorate drug-induced liver injuries in vitro. However, there are concerns regarding its clinical relevance as it remains a challenge to perform selective liver cooling in a non-invasive manner. To reconcile this dilemma, we propose the use of pulsed cooling for regional hypothermic conditioning in liver. This involves intermittent cooling applied in pulses of 15 min each, with a one-hour recovery interval between pulses. Cooling is achieved by applying ice packs to the cutaneous region overlying the liver. Through an in vivo C57BL/6NTac mouse study, we demonstrated the feasibility of attaining localized hypothermia close to the liver while maintaining core body temperature. This has successfully ameliorated acetaminophen-induced liver injury based on the liver function tests, liver histology and total weight change. Collectively, we provide a proof of concept for pulsed external localized cooling as being clinically actionable to perform induced selective hypothermia.
format	article
author	Yeong Lan Tan Min En Nga Han Kiat Ho
author_facet	Yeong Lan Tan Min En Nga Han Kiat Ho
author_sort	Yeong Lan Tan
title	In vivo demonstration of a novel non-invasive model for inducing localized hypothermia to ameliorate hepatotoxicity
title_short	In vivo demonstration of a novel non-invasive model for inducing localized hypothermia to ameliorate hepatotoxicity
title_full	In vivo demonstration of a novel non-invasive model for inducing localized hypothermia to ameliorate hepatotoxicity
title_fullStr	In vivo demonstration of a novel non-invasive model for inducing localized hypothermia to ameliorate hepatotoxicity
title_full_unstemmed	In vivo demonstration of a novel non-invasive model for inducing localized hypothermia to ameliorate hepatotoxicity
title_sort	in vivo demonstration of a novel non-invasive model for inducing localized hypothermia to ameliorate hepatotoxicity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d3730dcb0cf048a1bedb4709e89923ea
work_keys_str_mv	AT yeonglantan invivodemonstrationofanovelnoninvasivemodelforinducinglocalizedhypothermiatoamelioratehepatotoxicity AT minennga invivodemonstrationofanovelnoninvasivemodelforinducinglocalizedhypothermiatoamelioratehepatotoxicity AT hankiatho invivodemonstrationofanovelnoninvasivemodelforinducinglocalizedhypothermiatoamelioratehepatotoxicity
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In vivo demonstration of a novel non-invasive model for inducing localized hypothermia to ameliorate hepatotoxicity

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