Pilot study of minimum occlusive force of vascular clamps on arterial vessels in rats

Abstract Our aims were to determine the accuracy of an improved formula for determining the minimum occlusive force (MOF) of a vascular clamp on rats’ abdominal aortas, compare our findings with the calculated theoretical MOF, and provide reference data for clinical research and development of medic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rui Sun, Lizhi Ren, Zepeng Zhang, Xiaofen Wu, Qianqian Wang, Sui Zhang, Xiaowen Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d374a5fb274c4767bc3462f883224a1e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d374a5fb274c4767bc3462f883224a1e
record_format	dspace
spelling	oai:doaj.org-article:d374a5fb274c4767bc3462f883224a1e2021-12-02T16:31:14ZPilot study of minimum occlusive force of vascular clamps on arterial vessels in rats10.1038/s41598-021-84346-y2045-2322https://doaj.org/article/d374a5fb274c4767bc3462f883224a1e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84346-yhttps://doaj.org/toc/2045-2322Abstract Our aims were to determine the accuracy of an improved formula for determining the minimum occlusive force (MOF) of a vascular clamp on rats’ abdominal aortas, compare our findings with the calculated theoretical MOF, and provide reference data for clinical research and development of medical instruments that cause minimal damage. We created a vessel closure model and developed a formula for calculating the theoretical MOF of arterial vessels when they are occluded. This formula utilises the blood pressure in the blood vessel, its diameter, and the width of the vascular clamp. We then measured the actual MOF in 24 rat abdominal aortic segments with different diameters and different blood pressures and compared the theoretical and actual MOFs. Analysis of the experimental data showed a probability of 0.315, which means that, under the condition of normal distribution, the difference between the theoretical and actual MOF is not significant at the α = 0.05 level. Thus, the actual measured MOF tended to be consistent with the theoretical MOF calculated by the formula we developed. The improved formula will provide a reference for clinical research and development of medical instruments that cause minimal injury, thus contributing to the development of microsurgery.Rui SunLizhi RenZepeng ZhangXiaofen WuQianqian WangSui ZhangXiaowen YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rui Sun Lizhi Ren Zepeng Zhang Xiaofen Wu Qianqian Wang Sui Zhang Xiaowen Yang Pilot study of minimum occlusive force of vascular clamps on arterial vessels in rats
description	Abstract Our aims were to determine the accuracy of an improved formula for determining the minimum occlusive force (MOF) of a vascular clamp on rats’ abdominal aortas, compare our findings with the calculated theoretical MOF, and provide reference data for clinical research and development of medical instruments that cause minimal damage. We created a vessel closure model and developed a formula for calculating the theoretical MOF of arterial vessels when they are occluded. This formula utilises the blood pressure in the blood vessel, its diameter, and the width of the vascular clamp. We then measured the actual MOF in 24 rat abdominal aortic segments with different diameters and different blood pressures and compared the theoretical and actual MOFs. Analysis of the experimental data showed a probability of 0.315, which means that, under the condition of normal distribution, the difference between the theoretical and actual MOF is not significant at the α = 0.05 level. Thus, the actual measured MOF tended to be consistent with the theoretical MOF calculated by the formula we developed. The improved formula will provide a reference for clinical research and development of medical instruments that cause minimal injury, thus contributing to the development of microsurgery.
format	article
author	Rui Sun Lizhi Ren Zepeng Zhang Xiaofen Wu Qianqian Wang Sui Zhang Xiaowen Yang
author_facet	Rui Sun Lizhi Ren Zepeng Zhang Xiaofen Wu Qianqian Wang Sui Zhang Xiaowen Yang
author_sort	Rui Sun
title	Pilot study of minimum occlusive force of vascular clamps on arterial vessels in rats
title_short	Pilot study of minimum occlusive force of vascular clamps on arterial vessels in rats
title_full	Pilot study of minimum occlusive force of vascular clamps on arterial vessels in rats
title_fullStr	Pilot study of minimum occlusive force of vascular clamps on arterial vessels in rats
title_full_unstemmed	Pilot study of minimum occlusive force of vascular clamps on arterial vessels in rats
title_sort	pilot study of minimum occlusive force of vascular clamps on arterial vessels in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d374a5fb274c4767bc3462f883224a1e
work_keys_str_mv	AT ruisun pilotstudyofminimumocclusiveforceofvascularclampsonarterialvesselsinrats AT lizhiren pilotstudyofminimumocclusiveforceofvascularclampsonarterialvesselsinrats AT zepengzhang pilotstudyofminimumocclusiveforceofvascularclampsonarterialvesselsinrats AT xiaofenwu pilotstudyofminimumocclusiveforceofvascularclampsonarterialvesselsinrats AT qianqianwang pilotstudyofminimumocclusiveforceofvascularclampsonarterialvesselsinrats AT suizhang pilotstudyofminimumocclusiveforceofvascularclampsonarterialvesselsinrats AT xiaowenyang pilotstudyofminimumocclusiveforceofvascularclampsonarterialvesselsinrats
_version_	1718383902302666752

Pilot study of minimum occlusive force of vascular clamps on arterial vessels in rats

Ejemplares similares