Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

Mechanical forces induce bone remodeling, but how bone cells sense mechanical signaling is unclear. Here, the authors show that loss of the mechanotransduction channel Piezo1 in osteoblastic cells impairs osteoclast activity via YAP signaling and collagen expression, leading to reduced bone mass and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lijun Wang, Xiuling You, Sutada Lotinun, Lingli Zhang, Nan Wu, Weiguo Zou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d37c4da320be48d0aad1955eb3259e3c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d37c4da320be48d0aad1955eb3259e3c
record_format	dspace
spelling	oai:doaj.org-article:d37c4da320be48d0aad1955eb3259e3c2021-12-02T14:41:14ZMechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk10.1038/s41467-019-14146-62041-1723https://doaj.org/article/d37c4da320be48d0aad1955eb3259e3c2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14146-6https://doaj.org/toc/2041-1723Mechanical forces induce bone remodeling, but how bone cells sense mechanical signaling is unclear. Here, the authors show that loss of the mechanotransduction channel Piezo1 in osteoblastic cells impairs osteoclast activity via YAP signaling and collagen expression, leading to reduced bone mass and spontaneous fractures.Lijun WangXiuling YouSutada LotinunLingli ZhangNan WuWeiguo ZouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lijun Wang Xiuling You Sutada Lotinun Lingli Zhang Nan Wu Weiguo Zou Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
description	Mechanical forces induce bone remodeling, but how bone cells sense mechanical signaling is unclear. Here, the authors show that loss of the mechanotransduction channel Piezo1 in osteoblastic cells impairs osteoclast activity via YAP signaling and collagen expression, leading to reduced bone mass and spontaneous fractures.
format	article
author	Lijun Wang Xiuling You Sutada Lotinun Lingli Zhang Nan Wu Weiguo Zou
author_facet	Lijun Wang Xiuling You Sutada Lotinun Lingli Zhang Nan Wu Weiguo Zou
author_sort	Lijun Wang
title	Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
title_short	Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
title_full	Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
title_fullStr	Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
title_full_unstemmed	Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
title_sort	mechanical sensing protein piezo1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d37c4da320be48d0aad1955eb3259e3c
work_keys_str_mv	AT lijunwang mechanicalsensingproteinpiezo1regulatesbonehomeostasisviaosteoblastosteoclastcrosstalk AT xiulingyou mechanicalsensingproteinpiezo1regulatesbonehomeostasisviaosteoblastosteoclastcrosstalk AT sutadalotinun mechanicalsensingproteinpiezo1regulatesbonehomeostasisviaosteoblastosteoclastcrosstalk AT linglizhang mechanicalsensingproteinpiezo1regulatesbonehomeostasisviaosteoblastosteoclastcrosstalk AT nanwu mechanicalsensingproteinpiezo1regulatesbonehomeostasisviaosteoblastosteoclastcrosstalk AT weiguozou mechanicalsensingproteinpiezo1regulatesbonehomeostasisviaosteoblastosteoclastcrosstalk
_version_	1718389961085943808

Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

Ejemplares similares