DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies

Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer’s Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect children and young adults. All tauopathies share ectopic expression, mislocalization, or aggregation of the microtubule...

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Autores principales:	Geraldine Zimmer-Bensch, Hans Zempel
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alzheimer tauopathy TAU <i>MAPT</i> epigenetics neurodegeneration Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d37cc600ad824f99af45406ab5a87325
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spelling	oai:doaj.org-article:d37cc600ad824f99af45406ab5a873252021-11-25T17:11:03ZDNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies10.3390/cells101130642073-4409https://doaj.org/article/d37cc600ad824f99af45406ab5a873252021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3064https://doaj.org/toc/2073-4409Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer’s Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect children and young adults. All tauopathies share ectopic expression, mislocalization, or aggregation of the microtubule associated protein TAU, encoded by the <i>MAPT</i> gene. As TAU is a neuronal protein widely expressed in the CNS, the overwhelming majority of tauopathies are neurological disorders. They are characterized by cognitive dysfunction often leading to dementia, and are frequently accompanied by movement abnormalities such as parkinsonism. Tauopathies can lead to severe neurological deficits and premature death. For some tauopathies there is a clear genetic cause and/or an epigenetic contribution. However, for several others the disease etiology is unclear, with few tauopathies being environmentally triggered. Here, we review current knowledge of tauopathies listing known genetic and important sporadic forms of these disease. Further, we discuss how DNA methylation as a major epigenetic mechanism emerges to be involved in the disease pathophysiology of Alzheimer’s, and related genetic and non-genetic tauopathies. Finally, we debate the application of epigenetic signatures in peripheral blood samples as diagnostic tools and usages of epigenetic therapy strategies for these diseases.Geraldine Zimmer-BenschHans ZempelMDPI AGarticleAlzheimertauopathyTAU<i>MAPT</i>epigeneticsneurodegenerationBiology (General)QH301-705.5ENCells, Vol 10, Iss 3064, p 3064 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer tauopathy TAU <i>MAPT</i> epigenetics neurodegeneration Biology (General) QH301-705.5
spellingShingle	Alzheimer tauopathy TAU <i>MAPT</i> epigenetics neurodegeneration Biology (General) QH301-705.5 Geraldine Zimmer-Bensch Hans Zempel DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies
description	Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer’s Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect children and young adults. All tauopathies share ectopic expression, mislocalization, or aggregation of the microtubule associated protein TAU, encoded by the <i>MAPT</i> gene. As TAU is a neuronal protein widely expressed in the CNS, the overwhelming majority of tauopathies are neurological disorders. They are characterized by cognitive dysfunction often leading to dementia, and are frequently accompanied by movement abnormalities such as parkinsonism. Tauopathies can lead to severe neurological deficits and premature death. For some tauopathies there is a clear genetic cause and/or an epigenetic contribution. However, for several others the disease etiology is unclear, with few tauopathies being environmentally triggered. Here, we review current knowledge of tauopathies listing known genetic and important sporadic forms of these disease. Further, we discuss how DNA methylation as a major epigenetic mechanism emerges to be involved in the disease pathophysiology of Alzheimer’s, and related genetic and non-genetic tauopathies. Finally, we debate the application of epigenetic signatures in peripheral blood samples as diagnostic tools and usages of epigenetic therapy strategies for these diseases.
format	article
author	Geraldine Zimmer-Bensch Hans Zempel
author_facet	Geraldine Zimmer-Bensch Hans Zempel
author_sort	Geraldine Zimmer-Bensch
title	DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies
title_short	DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies
title_full	DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies
title_fullStr	DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies
title_full_unstemmed	DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies
title_sort	dna methylation in genetic and sporadic forms of neurodegeneration: lessons from alzheimer’s, related tauopathies and genetic tauopathies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d37cc600ad824f99af45406ab5a87325
work_keys_str_mv	AT geraldinezimmerbensch dnamethylationingeneticandsporadicformsofneurodegenerationlessonsfromalzheimersrelatedtauopathiesandgenetictauopathies AT hanszempel dnamethylationingeneticandsporadicformsofneurodegenerationlessonsfromalzheimersrelatedtauopathiesandgenetictauopathies
_version_	1718412681328721920

DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies

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