Retropharyngeal lymph node metastasis on N stage of nasopharyngeal carcinoma.

<h4>Purposes</h4>To evaluate retropharyngeal lymph node metastasis on N stage of nasopharyngeal carcinoma (NPC).<h4>Methods</h4>NPC patients were extracted from the Surveillance, Epidemiology, and End Results database between 2004 and 2016. Pathologically confirmed patients w...

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Autores principales:	Xin-Bin Pan, Shi-Ting Huang, Song Qu, Kai-Hua Chen, Yan-Ming Jiang, Xiao-Dong Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d37edd3c76cc412b839867ea6420a6ec
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spelling	oai:doaj.org-article:d37edd3c76cc412b839867ea6420a6ec2021-12-02T20:10:26ZRetropharyngeal lymph node metastasis on N stage of nasopharyngeal carcinoma.1932-620310.1371/journal.pone.0253424https://doaj.org/article/d37edd3c76cc412b839867ea6420a6ec2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253424https://doaj.org/toc/1932-6203<h4>Purposes</h4>To evaluate retropharyngeal lymph node metastasis on N stage of nasopharyngeal carcinoma (NPC).<h4>Methods</h4>NPC patients were extracted from the Surveillance, Epidemiology, and End Results database between 2004 and 2016. Pathologically confirmed patients with complete data of retropharyngeal lymph node metastasis were investigated. The included patients were divided into N1a and N1b groups. Overall survival (OS) and cancer-specific survival (CSS) were assessed using the Kaplan-Meier method and propensity score matching (PSM) analyses.<h4>Results</h4>This retrospective cohort study examined 759 patients: 70 who were stage N1a and 689 who were stage N1b. Before PSM, N1a group was associated with similar 5-year OS (77.7% vs. 72.4%; P = 0.15) and CSS (85.6% vs. 79.9%; P = 0.09) compared to N1b group. After PSM, a similar OS (75.0% vs. 60.7%; P = 0.12) was found between the radiotherapy and chemoradiotherapy groups. However, N1a group showed a better 5-year CSS (83.8% vs. 71.1%; P = 0.04) compared to N1b group. Stage N1b was an independent risk prognostic factor for CSS (hazard ratio = 2.54, 95% confidence interval: 1.02-6.34; P = 0.04).<h4>Conclusions</h4>OS was not different between N1a and N1b groups. Retropharyngeal lymph node metastasis defined as stage N1 of the 8th edition American Joint Committee on Cancer staging system is reasonable.Xin-Bin PanShi-Ting HuangSong QuKai-Hua ChenYan-Ming JiangXiao-Dong ZhuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253424 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin-Bin Pan Shi-Ting Huang Song Qu Kai-Hua Chen Yan-Ming Jiang Xiao-Dong Zhu Retropharyngeal lymph node metastasis on N stage of nasopharyngeal carcinoma.
description	<h4>Purposes</h4>To evaluate retropharyngeal lymph node metastasis on N stage of nasopharyngeal carcinoma (NPC).<h4>Methods</h4>NPC patients were extracted from the Surveillance, Epidemiology, and End Results database between 2004 and 2016. Pathologically confirmed patients with complete data of retropharyngeal lymph node metastasis were investigated. The included patients were divided into N1a and N1b groups. Overall survival (OS) and cancer-specific survival (CSS) were assessed using the Kaplan-Meier method and propensity score matching (PSM) analyses.<h4>Results</h4>This retrospective cohort study examined 759 patients: 70 who were stage N1a and 689 who were stage N1b. Before PSM, N1a group was associated with similar 5-year OS (77.7% vs. 72.4%; P = 0.15) and CSS (85.6% vs. 79.9%; P = 0.09) compared to N1b group. After PSM, a similar OS (75.0% vs. 60.7%; P = 0.12) was found between the radiotherapy and chemoradiotherapy groups. However, N1a group showed a better 5-year CSS (83.8% vs. 71.1%; P = 0.04) compared to N1b group. Stage N1b was an independent risk prognostic factor for CSS (hazard ratio = 2.54, 95% confidence interval: 1.02-6.34; P = 0.04).<h4>Conclusions</h4>OS was not different between N1a and N1b groups. Retropharyngeal lymph node metastasis defined as stage N1 of the 8th edition American Joint Committee on Cancer staging system is reasonable.
format	article
author	Xin-Bin Pan Shi-Ting Huang Song Qu Kai-Hua Chen Yan-Ming Jiang Xiao-Dong Zhu
author_facet	Xin-Bin Pan Shi-Ting Huang Song Qu Kai-Hua Chen Yan-Ming Jiang Xiao-Dong Zhu
author_sort	Xin-Bin Pan
title	Retropharyngeal lymph node metastasis on N stage of nasopharyngeal carcinoma.
title_short	Retropharyngeal lymph node metastasis on N stage of nasopharyngeal carcinoma.
title_full	Retropharyngeal lymph node metastasis on N stage of nasopharyngeal carcinoma.
title_fullStr	Retropharyngeal lymph node metastasis on N stage of nasopharyngeal carcinoma.
title_full_unstemmed	Retropharyngeal lymph node metastasis on N stage of nasopharyngeal carcinoma.
title_sort	retropharyngeal lymph node metastasis on n stage of nasopharyngeal carcinoma.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d37edd3c76cc412b839867ea6420a6ec
work_keys_str_mv	AT xinbinpan retropharyngeallymphnodemetastasisonnstageofnasopharyngealcarcinoma AT shitinghuang retropharyngeallymphnodemetastasisonnstageofnasopharyngealcarcinoma AT songqu retropharyngeallymphnodemetastasisonnstageofnasopharyngealcarcinoma AT kaihuachen retropharyngeallymphnodemetastasisonnstageofnasopharyngealcarcinoma AT yanmingjiang retropharyngeallymphnodemetastasisonnstageofnasopharyngealcarcinoma AT xiaodongzhu retropharyngeallymphnodemetastasisonnstageofnasopharyngealcarcinoma
_version_	1718375026899550208

Retropharyngeal lymph node metastasis on N stage of nasopharyngeal carcinoma.

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