Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)

The creation of innovative fibrous materials based on biodegradable semicrystalline polymers and modifying additives is an urgent scientific problem. In particular, the development of biomedical materials based on molecular complexes and biopolymers with controlled properties is of great interest. T...

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Autores principales:	Polina Tyubaeva, Ivetta Varyan, Anton Lobanov, Anatoly Olkhov, Anatoly Popov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	poly(3-hydroxybutyrate) porphyrin complex hemin semicrystalline polymer supramolecular structure electrospun fibrous materials Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/d380bd06b85c461eb661efeaa259dcca
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spelling	oai:doaj.org-article:d380bd06b85c461eb661efeaa259dcca2021-11-25T18:49:29ZEffect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)10.3390/polym132240242073-4360https://doaj.org/article/d380bd06b85c461eb661efeaa259dcca2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/4024https://doaj.org/toc/2073-4360The creation of innovative fibrous materials based on biodegradable semicrystalline polymers and modifying additives is an urgent scientific problem. In particular, the development of biomedical materials based on molecular complexes and biopolymers with controlled properties is of great interest. The paper suggests an approach to modifying the structure and properties of the composite materials based on poly(3-hydroxybutyrate) (PHB) obtained by the electrospinning method using molecular complexes of hemin. The introduction of 1–5 wt. % of hemin has a significant effect on the supramolecular structure, morphology and properties of PHB-based fibers. Changes in the supramolecular structure intensified with the increasing hemin concentration. On the one hand, a decrease in the fraction of the crystalline phase by 8–10% was observed. At the same time, there is a decrease in the density of the amorphous phase by 15–70%. Moreover, the addition of hemin leads to an improvement in the strength characteristics of the material: the elongation at break increased by 1.5 times, and in the tensile strength, it increased by 3 times. The antimicrobial activity of the hemin-containing composite materials against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> was confirmed. The obtained materials are proposed to be used in the creation of composite systems for regenerative medicine.Polina TyubaevaIvetta VaryanAnton LobanovAnatoly OlkhovAnatoly PopovMDPI AGarticlepoly(3-hydroxybutyrate)porphyrin complexheminsemicrystalline polymersupramolecular structureelectrospun fibrous materialsOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 4024, p 4024 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	poly(3-hydroxybutyrate) porphyrin complex hemin semicrystalline polymer supramolecular structure electrospun fibrous materials Organic chemistry QD241-441
spellingShingle	poly(3-hydroxybutyrate) porphyrin complex hemin semicrystalline polymer supramolecular structure electrospun fibrous materials Organic chemistry QD241-441 Polina Tyubaeva Ivetta Varyan Anton Lobanov Anatoly Olkhov Anatoly Popov Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)
description	The creation of innovative fibrous materials based on biodegradable semicrystalline polymers and modifying additives is an urgent scientific problem. In particular, the development of biomedical materials based on molecular complexes and biopolymers with controlled properties is of great interest. The paper suggests an approach to modifying the structure and properties of the composite materials based on poly(3-hydroxybutyrate) (PHB) obtained by the electrospinning method using molecular complexes of hemin. The introduction of 1–5 wt. % of hemin has a significant effect on the supramolecular structure, morphology and properties of PHB-based fibers. Changes in the supramolecular structure intensified with the increasing hemin concentration. On the one hand, a decrease in the fraction of the crystalline phase by 8–10% was observed. At the same time, there is a decrease in the density of the amorphous phase by 15–70%. Moreover, the addition of hemin leads to an improvement in the strength characteristics of the material: the elongation at break increased by 1.5 times, and in the tensile strength, it increased by 3 times. The antimicrobial activity of the hemin-containing composite materials against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> was confirmed. The obtained materials are proposed to be used in the creation of composite systems for regenerative medicine.
format	article
author	Polina Tyubaeva Ivetta Varyan Anton Lobanov Anatoly Olkhov Anatoly Popov
author_facet	Polina Tyubaeva Ivetta Varyan Anton Lobanov Anatoly Olkhov Anatoly Popov
author_sort	Polina Tyubaeva
title	Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)
title_short	Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)
title_full	Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)
title_fullStr	Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)
title_full_unstemmed	Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)
title_sort	effect of the hemin molecular complexes on the structure and properties of the composite electrospun materials based on poly(3-hydroxybutyrate)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d380bd06b85c461eb661efeaa259dcca
work_keys_str_mv	AT polinatyubaeva effectoftheheminmolecularcomplexesonthestructureandpropertiesofthecompositeelectrospunmaterialsbasedonpoly3hydroxybutyrate AT ivettavaryan effectoftheheminmolecularcomplexesonthestructureandpropertiesofthecompositeelectrospunmaterialsbasedonpoly3hydroxybutyrate AT antonlobanov effectoftheheminmolecularcomplexesonthestructureandpropertiesofthecompositeelectrospunmaterialsbasedonpoly3hydroxybutyrate AT anatolyolkhov effectoftheheminmolecularcomplexesonthestructureandpropertiesofthecompositeelectrospunmaterialsbasedonpoly3hydroxybutyrate AT anatolypopov effectoftheheminmolecularcomplexesonthestructureandpropertiesofthecompositeelectrospunmaterialsbasedonpoly3hydroxybutyrate
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Effect of the Hemin Molecular Complexes on the Structure and Properties of the Composite Electrospun Materials Based on Poly(3-hydroxybutyrate)

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