Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study.

<h4>Background</h4>It is not clear whether elevated uric acid is a risk factor for the onset of impaired fasting glucose after stratifying by baseline fasting plasma glucose levels. We conducted a community-based retrospective longitudinal cohort study to clarify the relationship between...

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Autores principales: Teruki Miyake, Teru Kumagi, Shinya Furukawa, Masashi Hirooka, Keitarou Kawasaki, Mitsuhito Koizumi, Yasuhiko Todo, Shin Yamamoto, Masanori Abe, Kohichiro Kitai, Bunzo Matsuura, Yoichi Hiasa
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Publicado: Public Library of Science (PLoS) 2014
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spelling oai:doaj.org-article:d385c83c6daa42a6a9f839f2773cae902021-11-25T06:00:04ZHyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study.1932-620310.1371/journal.pone.0107882https://doaj.org/article/d385c83c6daa42a6a9f839f2773cae902014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0107882https://doaj.org/toc/1932-6203<h4>Background</h4>It is not clear whether elevated uric acid is a risk factor for the onset of impaired fasting glucose after stratifying by baseline fasting plasma glucose levels. We conducted a community-based retrospective longitudinal cohort study to clarify the relationship between uric acid levels and the onset of impaired fasting glucose, according to baseline fasting plasma glucose levels.<h4>Methods</h4>We enrolled 6,403 persons (3,194 men and 3,209 women), each of whom was 18-80 years old and had > 2 annual check-ups during 2003-2010. After excluding persons who had fasting plasma glucose levels ≥ 6.11 mM and/or were currently taking anti-diabetic agents, the remaining 5,924 subjects were classified into quartiles according to baseline fasting plasma glucose levels. The onset of impaired fasting glucose was defined as fasting plasma glucose ≥ 6.11 mM during the observation period.<h4>Results</h4>In the quartile groups, 0.9%, 2.1%, 3.4%, and 20.2% of the men developed impaired fasting glucose, respectively, and 0.1%, 0.3%, 0.5%, and 5.6% of the women developed impaired fasting glucose, respectively (P trend <0.001). After adjusting for age, body mass index, systolic blood pressure, triacylglycerols, high density lipoprotein-cholesterol, creatinine, fatty liver, family history of diabetes, alcohol consumption, and current smoking, uric acid levels were positively associated with onset of impaired fasting glucose in men with highest-quartile fasting plasma glucose levels (adjusted hazard ratio, 1.003; 95% confidence interval, 1.0001-1.005, P = 0.041).<h4>Conclusions</h4>Among men with high fasting plasma glucose, hyperuricemia may be independently associated with an elevated risk of developing impaired fasting glucose.Teruki MiyakeTeru KumagiShinya FurukawaMasashi HirookaKeitarou KawasakiMitsuhito KoizumiYasuhiko TodoShin YamamotoMasanori AbeKohichiro KitaiBunzo MatsuuraYoichi HiasaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e107882 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Teruki Miyake
Teru Kumagi
Shinya Furukawa
Masashi Hirooka
Keitarou Kawasaki
Mitsuhito Koizumi
Yasuhiko Todo
Shin Yamamoto
Masanori Abe
Kohichiro Kitai
Bunzo Matsuura
Yoichi Hiasa
Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study.
description <h4>Background</h4>It is not clear whether elevated uric acid is a risk factor for the onset of impaired fasting glucose after stratifying by baseline fasting plasma glucose levels. We conducted a community-based retrospective longitudinal cohort study to clarify the relationship between uric acid levels and the onset of impaired fasting glucose, according to baseline fasting plasma glucose levels.<h4>Methods</h4>We enrolled 6,403 persons (3,194 men and 3,209 women), each of whom was 18-80 years old and had > 2 annual check-ups during 2003-2010. After excluding persons who had fasting plasma glucose levels ≥ 6.11 mM and/or were currently taking anti-diabetic agents, the remaining 5,924 subjects were classified into quartiles according to baseline fasting plasma glucose levels. The onset of impaired fasting glucose was defined as fasting plasma glucose ≥ 6.11 mM during the observation period.<h4>Results</h4>In the quartile groups, 0.9%, 2.1%, 3.4%, and 20.2% of the men developed impaired fasting glucose, respectively, and 0.1%, 0.3%, 0.5%, and 5.6% of the women developed impaired fasting glucose, respectively (P trend <0.001). After adjusting for age, body mass index, systolic blood pressure, triacylglycerols, high density lipoprotein-cholesterol, creatinine, fatty liver, family history of diabetes, alcohol consumption, and current smoking, uric acid levels were positively associated with onset of impaired fasting glucose in men with highest-quartile fasting plasma glucose levels (adjusted hazard ratio, 1.003; 95% confidence interval, 1.0001-1.005, P = 0.041).<h4>Conclusions</h4>Among men with high fasting plasma glucose, hyperuricemia may be independently associated with an elevated risk of developing impaired fasting glucose.
format article
author Teruki Miyake
Teru Kumagi
Shinya Furukawa
Masashi Hirooka
Keitarou Kawasaki
Mitsuhito Koizumi
Yasuhiko Todo
Shin Yamamoto
Masanori Abe
Kohichiro Kitai
Bunzo Matsuura
Yoichi Hiasa
author_facet Teruki Miyake
Teru Kumagi
Shinya Furukawa
Masashi Hirooka
Keitarou Kawasaki
Mitsuhito Koizumi
Yasuhiko Todo
Shin Yamamoto
Masanori Abe
Kohichiro Kitai
Bunzo Matsuura
Yoichi Hiasa
author_sort Teruki Miyake
title Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study.
title_short Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study.
title_full Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study.
title_fullStr Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study.
title_full_unstemmed Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study.
title_sort hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/d385c83c6daa42a6a9f839f2773cae90
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