Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques

The location and extent of intranasal oxytocin brain penetrance has not been shown. Here the authors show that oxytocin, administered intranasally, enters brain regions along the trajectories of the olfactory and trigeminal nerves and there, reaches biologically relevant concentrations.

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Detalles Bibliográficos
Autores principales: M. R. Lee, T. A. Shnitko, S. W. Blue, A. V. Kaucher, A. J. Winchell, D. W. Erikson, K. A. Grant, L. Leggio
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d3867b18524849f3b187518df818521b
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Sumario:The location and extent of intranasal oxytocin brain penetrance has not been shown. Here the authors show that oxytocin, administered intranasally, enters brain regions along the trajectories of the olfactory and trigeminal nerves and there, reaches biologically relevant concentrations.