Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques

The location and extent of intranasal oxytocin brain penetrance has not been shown. Here the authors show that oxytocin, administered intranasally, enters brain regions along the trajectories of the olfactory and trigeminal nerves and there, reaches biologically relevant concentrations.

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Detalles Bibliográficos
Autores principales:	M. R. Lee, T. A. Shnitko, S. W. Blue, A. V. Kaucher, A. J. Winchell, D. W. Erikson, K. A. Grant, L. Leggio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d3867b18524849f3b187518df818521b
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spelling	oai:doaj.org-article:d3867b18524849f3b187518df818521b2021-12-02T17:51:19ZLabeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques10.1038/s41467-020-15942-12041-1723https://doaj.org/article/d3867b18524849f3b187518df818521b2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15942-1https://doaj.org/toc/2041-1723The location and extent of intranasal oxytocin brain penetrance has not been shown. Here the authors show that oxytocin, administered intranasally, enters brain regions along the trajectories of the olfactory and trigeminal nerves and there, reaches biologically relevant concentrations.M. R. LeeT. A. ShnitkoS. W. BlueA. V. KaucherA. J. WinchellD. W. EriksonK. A. GrantL. LeggioNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. R. Lee T. A. Shnitko S. W. Blue A. V. Kaucher A. J. Winchell D. W. Erikson K. A. Grant L. Leggio Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques
description	The location and extent of intranasal oxytocin brain penetrance has not been shown. Here the authors show that oxytocin, administered intranasally, enters brain regions along the trajectories of the olfactory and trigeminal nerves and there, reaches biologically relevant concentrations.
format	article
author	M. R. Lee T. A. Shnitko S. W. Blue A. V. Kaucher A. J. Winchell D. W. Erikson K. A. Grant L. Leggio
author_facet	M. R. Lee T. A. Shnitko S. W. Blue A. V. Kaucher A. J. Winchell D. W. Erikson K. A. Grant L. Leggio
author_sort	M. R. Lee
title	Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques
title_short	Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques
title_full	Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques
title_fullStr	Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques
title_full_unstemmed	Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques
title_sort	labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d3867b18524849f3b187518df818521b
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Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques

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