Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats

Abstract The aim of this study was to prevent female osteoporosis using strength training (ST), raloxifene (Ral) or a combination of ST plus Ral during the natural female aging process, specifically in the periestropause period. For a total of 120 days, aging female Wistar rats at 18-21 months of ag...

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Autores principales:	Camila Tami Stringhetta-Garcia, Samuel Rodrigues Lourenço Morais, Fernanda Fernandes, Melise Jacon Perez-Ueno, Ricardo de Paula Almeida, Mário Jefferson Quirino Louzada, Antonio Hernandes Chaves-Neto, Edilson Ervolino, Rita Cássia Menegati Dornelles
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d38740865e94480299815361dd416e20
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spelling	oai:doaj.org-article:d38740865e94480299815361dd416e202021-12-02T11:52:32ZEffects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats10.1038/s41598-017-13098-52045-2322https://doaj.org/article/d38740865e94480299815361dd416e202017-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-13098-5https://doaj.org/toc/2045-2322Abstract The aim of this study was to prevent female osteoporosis using strength training (ST), raloxifene (Ral) or a combination of ST plus Ral during the natural female aging process, specifically in the periestropause period. For a total of 120 days, aging female Wistar rats at 18-21 months of age performed ST on a ladder three times per week, and Ral was administered daily by gavage (1 mg/kg/day). Bone microarchitecture, areal bone mineral density, bone strength of the femoral neck, immunohistochemistry, osteoclast and osteoblast surface were assessed. We found that the treatments modulate the bone remodeling cycle in different ways. Both ST and Ral treatment resulted in improved bone microarchitecture in the femoral neck of rats in late periestropause. However, only ST improved cortical microarchitecture and bone strength in the femoral neck. Thus, we suggest that performing ST during the late period of periestropause is a valid intervention to prevent age-associated osteoporosis in females.Camila Tami Stringhetta-GarciaSamuel Rodrigues Lourenço MoraisFernanda FernandesMelise Jacon Perez-UenoRicardo de Paula AlmeidaMário Jefferson Quirino LouzadaAntonio Hernandes Chaves-NetoEdilson ErvolinoRita Cássia Menegati DornellesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Camila Tami Stringhetta-Garcia Samuel Rodrigues Lourenço Morais Fernanda Fernandes Melise Jacon Perez-Ueno Ricardo de Paula Almeida Mário Jefferson Quirino Louzada Antonio Hernandes Chaves-Neto Edilson Ervolino Rita Cássia Menegati Dornelles Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats
description	Abstract The aim of this study was to prevent female osteoporosis using strength training (ST), raloxifene (Ral) or a combination of ST plus Ral during the natural female aging process, specifically in the periestropause period. For a total of 120 days, aging female Wistar rats at 18-21 months of age performed ST on a ladder three times per week, and Ral was administered daily by gavage (1 mg/kg/day). Bone microarchitecture, areal bone mineral density, bone strength of the femoral neck, immunohistochemistry, osteoclast and osteoblast surface were assessed. We found that the treatments modulate the bone remodeling cycle in different ways. Both ST and Ral treatment resulted in improved bone microarchitecture in the femoral neck of rats in late periestropause. However, only ST improved cortical microarchitecture and bone strength in the femoral neck. Thus, we suggest that performing ST during the late period of periestropause is a valid intervention to prevent age-associated osteoporosis in females.
format	article
author	Camila Tami Stringhetta-Garcia Samuel Rodrigues Lourenço Morais Fernanda Fernandes Melise Jacon Perez-Ueno Ricardo de Paula Almeida Mário Jefferson Quirino Louzada Antonio Hernandes Chaves-Neto Edilson Ervolino Rita Cássia Menegati Dornelles
author_facet	Camila Tami Stringhetta-Garcia Samuel Rodrigues Lourenço Morais Fernanda Fernandes Melise Jacon Perez-Ueno Ricardo de Paula Almeida Mário Jefferson Quirino Louzada Antonio Hernandes Chaves-Neto Edilson Ervolino Rita Cássia Menegati Dornelles
author_sort	Camila Tami Stringhetta-Garcia
title	Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats
title_short	Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats
title_full	Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats
title_fullStr	Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats
title_full_unstemmed	Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats
title_sort	effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female wistar rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d38740865e94480299815361dd416e20
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Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats

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