THE PERSPECTIVES OF DEVELOPMENT OF NEW PEPTIDE PREPARATIONS FOR CLINICAL USE WHICH HAVE ANTI-INFECTION AND IMMUNE-MODULATING ACTIVITY

Abstract. The aim of current work is to study influence of peptides in vitro and in vivo on cytokines synthesis (IFNα, IFNγ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-18, TNFα) on the level of their transcription and production. The study of synthesized peptides has shown that all of them had...

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Autores principales:	L. A. Andreeva, M. V. Mezentseva, A. N. Narovlianskiy, I. Ju. Nagaev, I. M. Shapoval, V. E. Scherbenko, L. I. Russu, N. F. Miasoedov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	peptides glycoprolines selank cytokines pharmacophor Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/d389a73ce72742039cea6e61eb8883fd
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spelling	oai:doaj.org-article:d389a73ce72742039cea6e61eb8883fd2021-11-22T07:09:45ZTHE PERSPECTIVES OF DEVELOPMENT OF NEW PEPTIDE PREPARATIONS FOR CLINICAL USE WHICH HAVE ANTI-INFECTION AND IMMUNE-MODULATING ACTIVITY2220-76192313-739810.15789/2220-7619-2011-2-171-176https://doaj.org/article/d389a73ce72742039cea6e61eb8883fd2014-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/43https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. The aim of current work is to study influence of peptides in vitro and in vivo on cytokines synthesis (IFNα, IFNγ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-18, TNFα) on the level of their transcription and production. The study of synthesized peptides has shown that all of them had antiviral activity related to tested pathogens (HSV, influenza H3N2, VEMC) with different grade. It could be explained by induction of cytokine response under the action of peptides in norm and in case of viral infections in vitro. However, data obtained in vivo, more adequately characterized antiviral activity of synthesized peptides. The results of study have shown that minimal fragments which had antiviral characteristics are dual peptides Thr-Lys and Gly-Pro; more active as antiviral was peptide Gly-Pro. Thus, our conception about possibility of minimal fragment’s selection from Selank peptide sequence having antiviral activity has been confirmed. This make possible directional construction of new peptides for clinical use which will be helpful in combating with social related diseases as influenza, herpes viral infection etc.L. A. AndreevaM. V. MezentsevaA. N. NarovlianskiyI. Ju. NagaevI. M. ShapovalV. E. ScherbenkoL. I. RussuN. F. MiasoedovSankt-Peterburg : NIIÈM imeni PasteraarticlepeptidesglycoprolinesselankcytokinespharmacophorInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 1, Iss 2, Pp 171-176 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	peptides glycoprolines selank cytokines pharmacophor Infectious and parasitic diseases RC109-216
spellingShingle	peptides glycoprolines selank cytokines pharmacophor Infectious and parasitic diseases RC109-216 L. A. Andreeva M. V. Mezentseva A. N. Narovlianskiy I. Ju. Nagaev I. M. Shapoval V. E. Scherbenko L. I. Russu N. F. Miasoedov THE PERSPECTIVES OF DEVELOPMENT OF NEW PEPTIDE PREPARATIONS FOR CLINICAL USE WHICH HAVE ANTI-INFECTION AND IMMUNE-MODULATING ACTIVITY
description	Abstract. The aim of current work is to study influence of peptides in vitro and in vivo on cytokines synthesis (IFNα, IFNγ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-18, TNFα) on the level of their transcription and production. The study of synthesized peptides has shown that all of them had antiviral activity related to tested pathogens (HSV, influenza H3N2, VEMC) with different grade. It could be explained by induction of cytokine response under the action of peptides in norm and in case of viral infections in vitro. However, data obtained in vivo, more adequately characterized antiviral activity of synthesized peptides. The results of study have shown that minimal fragments which had antiviral characteristics are dual peptides Thr-Lys and Gly-Pro; more active as antiviral was peptide Gly-Pro. Thus, our conception about possibility of minimal fragment’s selection from Selank peptide sequence having antiviral activity has been confirmed. This make possible directional construction of new peptides for clinical use which will be helpful in combating with social related diseases as influenza, herpes viral infection etc.
format	article
author	L. A. Andreeva M. V. Mezentseva A. N. Narovlianskiy I. Ju. Nagaev I. M. Shapoval V. E. Scherbenko L. I. Russu N. F. Miasoedov
author_facet	L. A. Andreeva M. V. Mezentseva A. N. Narovlianskiy I. Ju. Nagaev I. M. Shapoval V. E. Scherbenko L. I. Russu N. F. Miasoedov
author_sort	L. A. Andreeva
title	THE PERSPECTIVES OF DEVELOPMENT OF NEW PEPTIDE PREPARATIONS FOR CLINICAL USE WHICH HAVE ANTI-INFECTION AND IMMUNE-MODULATING ACTIVITY
title_short	THE PERSPECTIVES OF DEVELOPMENT OF NEW PEPTIDE PREPARATIONS FOR CLINICAL USE WHICH HAVE ANTI-INFECTION AND IMMUNE-MODULATING ACTIVITY
title_full	THE PERSPECTIVES OF DEVELOPMENT OF NEW PEPTIDE PREPARATIONS FOR CLINICAL USE WHICH HAVE ANTI-INFECTION AND IMMUNE-MODULATING ACTIVITY
title_fullStr	THE PERSPECTIVES OF DEVELOPMENT OF NEW PEPTIDE PREPARATIONS FOR CLINICAL USE WHICH HAVE ANTI-INFECTION AND IMMUNE-MODULATING ACTIVITY
title_full_unstemmed	THE PERSPECTIVES OF DEVELOPMENT OF NEW PEPTIDE PREPARATIONS FOR CLINICAL USE WHICH HAVE ANTI-INFECTION AND IMMUNE-MODULATING ACTIVITY
title_sort	perspectives of development of new peptide preparations for clinical use which have anti-infection and immune-modulating activity
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/d389a73ce72742039cea6e61eb8883fd
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THE PERSPECTIVES OF DEVELOPMENT OF NEW PEPTIDE PREPARATIONS FOR CLINICAL USE WHICH HAVE ANTI-INFECTION AND IMMUNE-MODULATING ACTIVITY

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