TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation.
In this issue of PLOS Biology, Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through...
Guardado en:
Autores principales: | , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/d38a86b8f72749e19121331d88c2b774 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:d38a86b8f72749e19121331d88c2b774 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:d38a86b8f72749e19121331d88c2b7742021-12-02T19:54:20ZTNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation.1544-91731545-788510.1371/journal.pbio.3001371https://doaj.org/article/d38a86b8f72749e19121331d88c2b7742021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001371https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885In this issue of PLOS Biology, Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through a novel pathway requiring synergism between apoptotic and pyroptotic caspases.Edward S MocarskiPratyusha MandalPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 8, p e3001371 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Biology (General) QH301-705.5 |
spellingShingle |
Biology (General) QH301-705.5 Edward S Mocarski Pratyusha Mandal TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation. |
description |
In this issue of PLOS Biology, Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through a novel pathway requiring synergism between apoptotic and pyroptotic caspases. |
format |
article |
author |
Edward S Mocarski Pratyusha Mandal |
author_facet |
Edward S Mocarski Pratyusha Mandal |
author_sort |
Edward S Mocarski |
title |
TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation. |
title_short |
TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation. |
title_full |
TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation. |
title_fullStr |
TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation. |
title_full_unstemmed |
TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation. |
title_sort |
tnf-dependent hyperactivation of ripk1-dependent cytotoxic signaling during embryogenesis and inflammation. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doaj.org/article/d38a86b8f72749e19121331d88c2b774 |
work_keys_str_mv |
AT edwardsmocarski tnfdependenthyperactivationofripk1dependentcytotoxicsignalingduringembryogenesisandinflammation AT pratyushamandal tnfdependenthyperactivationofripk1dependentcytotoxicsignalingduringembryogenesisandinflammation |
_version_ |
1718375929944735744 |