TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation.

In this issue of PLOS Biology, Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through...

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Autores principales: Edward S Mocarski, Pratyusha Mandal
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/d38a86b8f72749e19121331d88c2b774
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spelling oai:doaj.org-article:d38a86b8f72749e19121331d88c2b7742021-12-02T19:54:20ZTNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation.1544-91731545-788510.1371/journal.pbio.3001371https://doaj.org/article/d38a86b8f72749e19121331d88c2b7742021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001371https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885In this issue of PLOS Biology, Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through a novel pathway requiring synergism between apoptotic and pyroptotic caspases.Edward S MocarskiPratyusha MandalPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 8, p e3001371 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Edward S Mocarski
Pratyusha Mandal
TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation.
description In this issue of PLOS Biology, Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through a novel pathway requiring synergism between apoptotic and pyroptotic caspases.
format article
author Edward S Mocarski
Pratyusha Mandal
author_facet Edward S Mocarski
Pratyusha Mandal
author_sort Edward S Mocarski
title TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation.
title_short TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation.
title_full TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation.
title_fullStr TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation.
title_full_unstemmed TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation.
title_sort tnf-dependent hyperactivation of ripk1-dependent cytotoxic signaling during embryogenesis and inflammation.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/d38a86b8f72749e19121331d88c2b774
work_keys_str_mv AT edwardsmocarski tnfdependenthyperactivationofripk1dependentcytotoxicsignalingduringembryogenesisandinflammation
AT pratyushamandal tnfdependenthyperactivationofripk1dependentcytotoxicsignalingduringembryogenesisandinflammation
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