Platelet Function, Role in Thrombosis, Inflammation, and Consequences in Chronic Myeloproliferative Disorders

Platelets are conventionally defined as playing a vital role in homeostasis and thrombosis. This role has over the years transformed as knowledge regarding platelets has expanded to include inflammation, cancer progression, and metastasis. Upon platelet activation and subsequent aggregation, platele...

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Autores principales:	Lisa Repsold, Anna Margaretha Joubert
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	platelets inflammation thrombosis myeloproliferative disorders Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d393dd954f214fb3ba24f8c301e9642b
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spelling	oai:doaj.org-article:d393dd954f214fb3ba24f8c301e9642b2021-11-25T17:10:37ZPlatelet Function, Role in Thrombosis, Inflammation, and Consequences in Chronic Myeloproliferative Disorders10.3390/cells101130342073-4409https://doaj.org/article/d393dd954f214fb3ba24f8c301e9642b2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3034https://doaj.org/toc/2073-4409Platelets are conventionally defined as playing a vital role in homeostasis and thrombosis. This role has over the years transformed as knowledge regarding platelets has expanded to include inflammation, cancer progression, and metastasis. Upon platelet activation and subsequent aggregation, platelets release a host of various factors, including numerous pro-inflammatory factors. These pro-inflammatory factors are recruiters and activators of leukocytes, aiding in platelets’ immune regulating function and inflammatory function. These various platelet functions are interrelated; activation of the inflammatory function results in thrombosis and, moreover, in various disease conditions, can result in worsened or chronic pathogenesis, including cancer. The role and contribution of platelets in a multitude of pathophysiological events during hemostasis, thrombosis, inflammation, cancer progression, and metastasis is an important focus for ongoing research. Platelet activation as discussed here is present in all platelet functionalities and can result in a multitude of factors and signaling pathways being activated. The cross-talk between inflammation, cancer, and platelets is therefore an ideal target for research and treatment strategies through antiplatelet therapy. Despite the knowledge implicating platelets in these mentioned processes, there is, nevertheless, limited literature available on the involvement and impact of platelets in many diseases, including myeloproliferative neoplasms. The extensive role platelets play in the processes discussed here is irrefutable, yet we do not fully understand the complete interrelation and extent of these processes.Lisa RepsoldAnna Margaretha JoubertMDPI AGarticleplateletsinflammationthrombosismyeloproliferative disordersBiology (General)QH301-705.5ENCells, Vol 10, Iss 3034, p 3034 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	platelets inflammation thrombosis myeloproliferative disorders Biology (General) QH301-705.5
spellingShingle	platelets inflammation thrombosis myeloproliferative disorders Biology (General) QH301-705.5 Lisa Repsold Anna Margaretha Joubert Platelet Function, Role in Thrombosis, Inflammation, and Consequences in Chronic Myeloproliferative Disorders
description	Platelets are conventionally defined as playing a vital role in homeostasis and thrombosis. This role has over the years transformed as knowledge regarding platelets has expanded to include inflammation, cancer progression, and metastasis. Upon platelet activation and subsequent aggregation, platelets release a host of various factors, including numerous pro-inflammatory factors. These pro-inflammatory factors are recruiters and activators of leukocytes, aiding in platelets’ immune regulating function and inflammatory function. These various platelet functions are interrelated; activation of the inflammatory function results in thrombosis and, moreover, in various disease conditions, can result in worsened or chronic pathogenesis, including cancer. The role and contribution of platelets in a multitude of pathophysiological events during hemostasis, thrombosis, inflammation, cancer progression, and metastasis is an important focus for ongoing research. Platelet activation as discussed here is present in all platelet functionalities and can result in a multitude of factors and signaling pathways being activated. The cross-talk between inflammation, cancer, and platelets is therefore an ideal target for research and treatment strategies through antiplatelet therapy. Despite the knowledge implicating platelets in these mentioned processes, there is, nevertheless, limited literature available on the involvement and impact of platelets in many diseases, including myeloproliferative neoplasms. The extensive role platelets play in the processes discussed here is irrefutable, yet we do not fully understand the complete interrelation and extent of these processes.
format	article
author	Lisa Repsold Anna Margaretha Joubert
author_facet	Lisa Repsold Anna Margaretha Joubert
author_sort	Lisa Repsold
title	Platelet Function, Role in Thrombosis, Inflammation, and Consequences in Chronic Myeloproliferative Disorders
title_short	Platelet Function, Role in Thrombosis, Inflammation, and Consequences in Chronic Myeloproliferative Disorders
title_full	Platelet Function, Role in Thrombosis, Inflammation, and Consequences in Chronic Myeloproliferative Disorders
title_fullStr	Platelet Function, Role in Thrombosis, Inflammation, and Consequences in Chronic Myeloproliferative Disorders
title_full_unstemmed	Platelet Function, Role in Thrombosis, Inflammation, and Consequences in Chronic Myeloproliferative Disorders
title_sort	platelet function, role in thrombosis, inflammation, and consequences in chronic myeloproliferative disorders
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d393dd954f214fb3ba24f8c301e9642b
work_keys_str_mv	AT lisarepsold plateletfunctionroleinthrombosisinflammationandconsequencesinchronicmyeloproliferativedisorders AT annamargarethajoubert plateletfunctionroleinthrombosisinflammationandconsequencesinchronicmyeloproliferativedisorders
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Platelet Function, Role in Thrombosis, Inflammation, and Consequences in Chronic Myeloproliferative Disorders

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