Differences between two sodium hyaluronate-based submucosal injection materials currently used in Japan based on viscosity analysis

Differences between two sodium hyaluronate-based submucosal injection materials currently used in Japan based on viscosity analysis

Abstract In Japan, two 0.4% sodium hyaluronate (HA)-based submucosal injection materials (SIMs) are currently used in endoscopic submucosal dissection (ESD): MucoUp (HA-Mc) and Ksmart (HA-Ks). HA-Mc and HA-Ks have the same concentration and are, thus, construed by most endoscopists to have no differ...

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Autores principales: Ryohei Hirose, Takuma Yoshida, Yuji Naito, Naoto Watanabe, Hikaru Hashimoto, Satoshi Sugino, Risa Bandou, Tomo Daidoji, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Takaaki Nakaya, Yoshito Itoh
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:d395186fb309493b8695a41d43fd622d2021-12-02T15:54:01ZDifferences between two sodium hyaluronate-based submucosal injection materials currently used in Japan based on viscosity analysis10.1038/s41598-021-85118-42045-2322https://doaj.org/article/d395186fb309493b8695a41d43fd622d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85118-4https://doaj.org/toc/2045-2322Abstract In Japan, two 0.4% sodium hyaluronate (HA)-based submucosal injection materials (SIMs) are currently used in endoscopic submucosal dissection (ESD): MucoUp (HA-Mc) and Ksmart (HA-Ks). HA-Mc and HA-Ks have the same concentration and are, thus, construed by most endoscopists to have no difference. Nevertheless, visual observation conveys the impression that HA-Ks have a higher viscosity than HA-Mc, suggesting that HA-Ks performs better than HA-Mc. This study aimed to examine the differences between HA-Mc and HA-Ks. HA-Ks exhibited higher viscosity due to greater weight-average molecular weight compared with HA-Mc. HA-Ks had significantly greater submucosal elevation height (SEH) than HA-Mc; the SEH of HA-Ks-80% (80% dilution of HA-Ks) was the same as that of HA-Mc. The ESD procedure time was significantly shorter with HA-Ks than with HA-Mc (15.2 ± 4.1 vs. 19.5 ± 5.9; P = 0.049). The total injection volume for HA-Ks was significantly lower than that for HA-Mc (10.8 ± 3.6 vs. 14.4 ± 4.6; P = 0.045). However, no significant difference in these items was observed between HA-Mc and HA-Ks-80%. HA-Mc and HA-Ks were considered to be almost the same. Nonetheless, HA-Ks exhibited higher viscosity and SIM performance than HA-Mc. HA-Ks-80% had almost the same performance as HA-Mc. Thus, understanding SIM performance and characteristics requires a focus on the viscosity of SIMs.Ryohei HiroseTakuma YoshidaYuji NaitoNaoto WatanabeHikaru HashimotoSatoshi SuginoRisa BandouTomo DaidojiKen InoueOsamu DohiNaohisa YoshidaTakaaki NakayaYoshito ItohNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ryohei Hirose
Takuma Yoshida
Yuji Naito
Naoto Watanabe
Hikaru Hashimoto
Satoshi Sugino
Risa Bandou
Tomo Daidoji
Ken Inoue
Osamu Dohi
Naohisa Yoshida
Takaaki Nakaya
Yoshito Itoh
Differences between two sodium hyaluronate-based submucosal injection materials currently used in Japan based on viscosity analysis
description Abstract In Japan, two 0.4% sodium hyaluronate (HA)-based submucosal injection materials (SIMs) are currently used in endoscopic submucosal dissection (ESD): MucoUp (HA-Mc) and Ksmart (HA-Ks). HA-Mc and HA-Ks have the same concentration and are, thus, construed by most endoscopists to have no difference. Nevertheless, visual observation conveys the impression that HA-Ks have a higher viscosity than HA-Mc, suggesting that HA-Ks performs better than HA-Mc. This study aimed to examine the differences between HA-Mc and HA-Ks. HA-Ks exhibited higher viscosity due to greater weight-average molecular weight compared with HA-Mc. HA-Ks had significantly greater submucosal elevation height (SEH) than HA-Mc; the SEH of HA-Ks-80% (80% dilution of HA-Ks) was the same as that of HA-Mc. The ESD procedure time was significantly shorter with HA-Ks than with HA-Mc (15.2 ± 4.1 vs. 19.5 ± 5.9; P = 0.049). The total injection volume for HA-Ks was significantly lower than that for HA-Mc (10.8 ± 3.6 vs. 14.4 ± 4.6; P = 0.045). However, no significant difference in these items was observed between HA-Mc and HA-Ks-80%. HA-Mc and HA-Ks were considered to be almost the same. Nonetheless, HA-Ks exhibited higher viscosity and SIM performance than HA-Mc. HA-Ks-80% had almost the same performance as HA-Mc. Thus, understanding SIM performance and characteristics requires a focus on the viscosity of SIMs.
format article
author Ryohei Hirose
Takuma Yoshida
Yuji Naito
Naoto Watanabe
Hikaru Hashimoto
Satoshi Sugino
Risa Bandou
Tomo Daidoji
Ken Inoue
Osamu Dohi
Naohisa Yoshida
Takaaki Nakaya
Yoshito Itoh
author_facet Ryohei Hirose
Takuma Yoshida
Yuji Naito
Naoto Watanabe
Hikaru Hashimoto
Satoshi Sugino
Risa Bandou
Tomo Daidoji
Ken Inoue
Osamu Dohi
Naohisa Yoshida
Takaaki Nakaya
Yoshito Itoh
author_sort Ryohei Hirose
title Differences between two sodium hyaluronate-based submucosal injection materials currently used in Japan based on viscosity analysis
title_short Differences between two sodium hyaluronate-based submucosal injection materials currently used in Japan based on viscosity analysis
title_full Differences between two sodium hyaluronate-based submucosal injection materials currently used in Japan based on viscosity analysis
title_fullStr Differences between two sodium hyaluronate-based submucosal injection materials currently used in Japan based on viscosity analysis
title_full_unstemmed Differences between two sodium hyaluronate-based submucosal injection materials currently used in Japan based on viscosity analysis
title_sort differences between two sodium hyaluronate-based submucosal injection materials currently used in japan based on viscosity analysis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/d395186fb309493b8695a41d43fd622d
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