A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25

A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25

USP25 is a deubiquitinating enzyme and a positive regulator of Wnt/β-catenin signaling. Here the authors present the crystal structure of USP25 in a tetrameric inactive state and their biochemical and kinetic assays support an USP25 autoinhibitory mechanism that is mediated through a dimer to tetram...

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Autores principales: Bing Liu, Marta Sureda-Gómez, Yang Zhen, Virginia Amador, David Reverter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d3952516fdd9440481efad6314284dfd
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spelling oai:doaj.org-article:d3952516fdd9440481efad6314284dfd2021-12-02T14:41:17ZA quaternary tetramer assembly inhibits the deubiquitinating activity of USP2510.1038/s41467-018-07510-52041-1723https://doaj.org/article/d3952516fdd9440481efad6314284dfd2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07510-5https://doaj.org/toc/2041-1723USP25 is a deubiquitinating enzyme and a positive regulator of Wnt/β-catenin signaling. Here the authors present the crystal structure of USP25 in a tetrameric inactive state and their biochemical and kinetic assays support an USP25 autoinhibitory mechanism that is mediated through a dimer to tetramerization transition.Bing LiuMarta Sureda-GómezYang ZhenVirginia AmadorDavid ReverterNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bing Liu
Marta Sureda-Gómez
Yang Zhen
Virginia Amador
David Reverter
A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25
description USP25 is a deubiquitinating enzyme and a positive regulator of Wnt/β-catenin signaling. Here the authors present the crystal structure of USP25 in a tetrameric inactive state and their biochemical and kinetic assays support an USP25 autoinhibitory mechanism that is mediated through a dimer to tetramerization transition.
format article
author Bing Liu
Marta Sureda-Gómez
Yang Zhen
Virginia Amador
David Reverter
author_facet Bing Liu
Marta Sureda-Gómez
Yang Zhen
Virginia Amador
David Reverter
author_sort Bing Liu
title A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25
title_short A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25
title_full A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25
title_fullStr A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25
title_full_unstemmed A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25
title_sort quaternary tetramer assembly inhibits the deubiquitinating activity of usp25
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/d3952516fdd9440481efad6314284dfd
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