Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis

Abstract Chronic rheumatological manifestations similar to those of rheumatoid arthritis (RA) are described after chikungunya virus infection. We aimed to compare the relevance of joint counts and symptoms to clinical outcomes in RA and chronic chikungunya disease. Forty patients with chronic chikun...

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Autores principales:	Hugh Watson, Ramão Luciano Nogueira-Hayd, Maony Rodrigues-Moreno, Felipe Naveca, Giulia Calusi, Karol Suchowiecki, Gary S. Firestein, Gary Simon, Aileen Y. Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d3967d5fca6a4114a272fe872fccbc9f
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spelling	oai:doaj.org-article:d3967d5fca6a4114a272fe872fccbc9f2021-12-02T15:15:44ZTender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis10.1038/s41598-021-98164-92045-2322https://doaj.org/article/d3967d5fca6a4114a272fe872fccbc9f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98164-9https://doaj.org/toc/2045-2322Abstract Chronic rheumatological manifestations similar to those of rheumatoid arthritis (RA) are described after chikungunya virus infection. We aimed to compare the relevance of joint counts and symptoms to clinical outcomes in RA and chronic chikungunya disease. Forty patients with chronic chikungunya arthralgia and 40 patients with RA were enrolled in a cross-sectional study. The association of tenderness and swelling, clinically assessed in 28 joints, and patient evaluations of pain and musculoskeletal stiffness with modified Health Assessment Questionnaire (HAQ) and quality of life (QoL) assessments were investigated. Tender and swollen joint counts, pain and stiffness scores were all associated with the HAQ disability index in RA (all r > 0.55, p ≤ 0.0002), but only stiffness was significantly associated with disability in chikungunya (r = 0.38, p = 0.02). Joint counts, pain and stiffness were also associated with most QoL domains in RA patients. In contrast, in chikungunya disease, tender joint counts were associated only with one QoL domain and swollen joints for none, while pain and stiffness were associated with several domains. Our results confirm the relevance of joint counts in RA, but suggest that in chronic chikungunya disease, joint counts have more limited value. Stiffness and pain score may be more important to quantify chikungunya arthritis impact.Hugh WatsonRamão Luciano Nogueira-HaydMaony Rodrigues-MorenoFelipe NavecaGiulia CalusiKarol SuchowieckiGary S. FiresteinGary SimonAileen Y. ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hugh Watson Ramão Luciano Nogueira-Hayd Maony Rodrigues-Moreno Felipe Naveca Giulia Calusi Karol Suchowiecki Gary S. Firestein Gary Simon Aileen Y. Chang Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis
description	Abstract Chronic rheumatological manifestations similar to those of rheumatoid arthritis (RA) are described after chikungunya virus infection. We aimed to compare the relevance of joint counts and symptoms to clinical outcomes in RA and chronic chikungunya disease. Forty patients with chronic chikungunya arthralgia and 40 patients with RA were enrolled in a cross-sectional study. The association of tenderness and swelling, clinically assessed in 28 joints, and patient evaluations of pain and musculoskeletal stiffness with modified Health Assessment Questionnaire (HAQ) and quality of life (QoL) assessments were investigated. Tender and swollen joint counts, pain and stiffness scores were all associated with the HAQ disability index in RA (all r > 0.55, p ≤ 0.0002), but only stiffness was significantly associated with disability in chikungunya (r = 0.38, p = 0.02). Joint counts, pain and stiffness were also associated with most QoL domains in RA patients. In contrast, in chikungunya disease, tender joint counts were associated only with one QoL domain and swollen joints for none, while pain and stiffness were associated with several domains. Our results confirm the relevance of joint counts in RA, but suggest that in chronic chikungunya disease, joint counts have more limited value. Stiffness and pain score may be more important to quantify chikungunya arthritis impact.
format	article
author	Hugh Watson Ramão Luciano Nogueira-Hayd Maony Rodrigues-Moreno Felipe Naveca Giulia Calusi Karol Suchowiecki Gary S. Firestein Gary Simon Aileen Y. Chang
author_facet	Hugh Watson Ramão Luciano Nogueira-Hayd Maony Rodrigues-Moreno Felipe Naveca Giulia Calusi Karol Suchowiecki Gary S. Firestein Gary Simon Aileen Y. Chang
author_sort	Hugh Watson
title	Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis
title_short	Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis
title_full	Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis
title_fullStr	Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis
title_full_unstemmed	Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis
title_sort	tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d3967d5fca6a4114a272fe872fccbc9f
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Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis

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