<i>Armillaria luteo-virens Sacc</i> Ameliorates Dextran Sulfate Sodium Induced Colitis through Modulation of Gut Microbiota and Microbiota-Related Bile Acids

<i>Armillaria luteo-virens Sacc</i> (ALS) is a rare wild Chinese medicinal and edible basidiomycete. However, its protective effect on intestinal functions and the underlying mechanism is still unknown. This work explored the improvement of dextran sulfate sodium (DSS)-induced colitis by...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nana Zhang, Jianlin Liu, Xinxin Guo, Shuying Li, Fengzhong Wang, Minjie Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Armillaria luteo-virens Sacc</i> colitis gut microbes bile acid intestinal barrier inflammation Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/d39865cc54b0405ba584c397bf712099
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d39865cc54b0405ba584c397bf712099
record_format	dspace
spelling	oai:doaj.org-article:d39865cc54b0405ba584c397bf7120992021-11-25T18:35:23Z<i>Armillaria luteo-virens Sacc</i> Ameliorates Dextran Sulfate Sodium Induced Colitis through Modulation of Gut Microbiota and Microbiota-Related Bile Acids10.3390/nu131139262072-6643https://doaj.org/article/d39865cc54b0405ba584c397bf7120992021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3926https://doaj.org/toc/2072-6643<i>Armillaria luteo-virens Sacc</i> (ALS) is a rare wild Chinese medicinal and edible basidiomycete. However, its protective effect on intestinal functions and the underlying mechanism is still unknown. This work explored the improvement of dextran sulfate sodium (DSS)-induced colitis by ALS. ALS supplementation markedly improved colitis symptoms, gut barrier integrity, and goblet loss in DSS-treated mice. In addition, ALS inhibited colonic inflammation through the inhibition/activation of the mitogen-activated protein kinases/NF-κB signaling pathway. The 16S rRNA gene-based microbiota analysis revealed that ALS altered the gut microbiota composition, decreasing the richness of <i>Enterobacteriaceae</i> and increasing the abundance of <i>Lactobacillaceae</i>. The bile-acid-targeted metabolomic analysis showed that ALS recovered the microbial bile acid metabolism in the gut, enabling the activation of the farnesoid X receptor signaling by these acids, thus maintaining the intestinal homeostasis. Importantly, broad-spectrum antibiotic treatment reduced the efficacy of ALS-induced protection from colitis. Overall, our findings suggest that ALS may represent a novel approach in the nutritional intervention to prevent colitis.Nana ZhangJianlin LiuXinxin GuoShuying LiFengzhong WangMinjie WangMDPI AGarticle<i>Armillaria luteo-virens Sacc</i>colitisgut microbesbile acidintestinal barrierinflammationNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3926, p 3926 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Armillaria luteo-virens Sacc</i> colitis gut microbes bile acid intestinal barrier inflammation Nutrition. Foods and food supply TX341-641
spellingShingle	<i>Armillaria luteo-virens Sacc</i> colitis gut microbes bile acid intestinal barrier inflammation Nutrition. Foods and food supply TX341-641 Nana Zhang Jianlin Liu Xinxin Guo Shuying Li Fengzhong Wang Minjie Wang <i>Armillaria luteo-virens Sacc</i> Ameliorates Dextran Sulfate Sodium Induced Colitis through Modulation of Gut Microbiota and Microbiota-Related Bile Acids
description	<i>Armillaria luteo-virens Sacc</i> (ALS) is a rare wild Chinese medicinal and edible basidiomycete. However, its protective effect on intestinal functions and the underlying mechanism is still unknown. This work explored the improvement of dextran sulfate sodium (DSS)-induced colitis by ALS. ALS supplementation markedly improved colitis symptoms, gut barrier integrity, and goblet loss in DSS-treated mice. In addition, ALS inhibited colonic inflammation through the inhibition/activation of the mitogen-activated protein kinases/NF-κB signaling pathway. The 16S rRNA gene-based microbiota analysis revealed that ALS altered the gut microbiota composition, decreasing the richness of <i>Enterobacteriaceae</i> and increasing the abundance of <i>Lactobacillaceae</i>. The bile-acid-targeted metabolomic analysis showed that ALS recovered the microbial bile acid metabolism in the gut, enabling the activation of the farnesoid X receptor signaling by these acids, thus maintaining the intestinal homeostasis. Importantly, broad-spectrum antibiotic treatment reduced the efficacy of ALS-induced protection from colitis. Overall, our findings suggest that ALS may represent a novel approach in the nutritional intervention to prevent colitis.
format	article
author	Nana Zhang Jianlin Liu Xinxin Guo Shuying Li Fengzhong Wang Minjie Wang
author_facet	Nana Zhang Jianlin Liu Xinxin Guo Shuying Li Fengzhong Wang Minjie Wang
author_sort	Nana Zhang
title	<i>Armillaria luteo-virens Sacc</i> Ameliorates Dextran Sulfate Sodium Induced Colitis through Modulation of Gut Microbiota and Microbiota-Related Bile Acids
title_short	<i>Armillaria luteo-virens Sacc</i> Ameliorates Dextran Sulfate Sodium Induced Colitis through Modulation of Gut Microbiota and Microbiota-Related Bile Acids
title_full	<i>Armillaria luteo-virens Sacc</i> Ameliorates Dextran Sulfate Sodium Induced Colitis through Modulation of Gut Microbiota and Microbiota-Related Bile Acids
title_fullStr	<i>Armillaria luteo-virens Sacc</i> Ameliorates Dextran Sulfate Sodium Induced Colitis through Modulation of Gut Microbiota and Microbiota-Related Bile Acids
title_full_unstemmed	<i>Armillaria luteo-virens Sacc</i> Ameliorates Dextran Sulfate Sodium Induced Colitis through Modulation of Gut Microbiota and Microbiota-Related Bile Acids
title_sort	<i>armillaria luteo-virens sacc</i> ameliorates dextran sulfate sodium induced colitis through modulation of gut microbiota and microbiota-related bile acids
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d39865cc54b0405ba584c397bf712099
work_keys_str_mv	AT nanazhang iarmillarialuteovirenssacciamelioratesdextransulfatesodiuminducedcolitisthroughmodulationofgutmicrobiotaandmicrobiotarelatedbileacids AT jianlinliu iarmillarialuteovirenssacciamelioratesdextransulfatesodiuminducedcolitisthroughmodulationofgutmicrobiotaandmicrobiotarelatedbileacids AT xinxinguo iarmillarialuteovirenssacciamelioratesdextransulfatesodiuminducedcolitisthroughmodulationofgutmicrobiotaandmicrobiotarelatedbileacids AT shuyingli iarmillarialuteovirenssacciamelioratesdextransulfatesodiuminducedcolitisthroughmodulationofgutmicrobiotaandmicrobiotarelatedbileacids AT fengzhongwang iarmillarialuteovirenssacciamelioratesdextransulfatesodiuminducedcolitisthroughmodulationofgutmicrobiotaandmicrobiotarelatedbileacids AT minjiewang iarmillarialuteovirenssacciamelioratesdextransulfatesodiuminducedcolitisthroughmodulationofgutmicrobiotaandmicrobiotarelatedbileacids
_version_	1718410980319297536

<i>Armillaria luteo-virens Sacc</i> Ameliorates Dextran Sulfate Sodium Induced Colitis through Modulation of Gut Microbiota and Microbiota-Related Bile Acids

Ejemplares similares