Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles

Menglei Wang,1 Xuan Lai,2 Longquan Shao,2 Li Li1 1Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China; 2Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China Abstract: Nanotechnology i...

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Autores principales:	Wang M, Lai X, Shao L, Li L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	metallic nanoparticles transdermal penetration toxicity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d39a233d9879459fb03f469f7116b57d
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spelling	oai:doaj.org-article:d39a233d9879459fb03f469f7116b57d2021-12-02T05:16:59ZEvaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles1178-2013https://doaj.org/article/d39a233d9879459fb03f469f7116b57d2018-08-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-immunoresponses-and-cytotoxicity-from-skin-exposure-to-m-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Menglei Wang,1 Xuan Lai,2 Longquan Shao,2 Li Li1 1Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China; 2Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China Abstract: Nanotechnology is an interdisciplinary science that has developed rapidly in recent years. Metallic nanoparticles (NPs) are increasingly utilized in dermatology and cosmetology, because of their unique properties. However, skin exposure to NPs raises concerns regarding their transdermal toxicity. The tight junctions of epithelial cells form the skin barrier, which protects the host against external substances. Recent studies have found that NPs can pass through the skin barrier into deeper layers, indicating that skin exposure is a means for NPs to enter the body. The distribution and interaction of NPs with skin cells may cause toxic side effects. In this review, possible penetration pathways and related toxicity mechanisms are discussed. The limitations of current experimental methods on the penetration and toxic effects of metallic NPs are also described. This review contributes to a better understanding of the risks of topically applied metallic NPs and provides a foundation for future studies. Keywords: metallic nanoparticles, transdermal penetration, toxicityWang MLai XShao LLi LDove Medical Pressarticlemetallic nanoparticlestransdermal penetrationtoxicityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 4445-4459 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	metallic nanoparticles transdermal penetration toxicity Medicine (General) R5-920
spellingShingle	metallic nanoparticles transdermal penetration toxicity Medicine (General) R5-920 Wang M Lai X Shao L Li L Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles
description	Menglei Wang,1 Xuan Lai,2 Longquan Shao,2 Li Li1 1Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China; 2Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China Abstract: Nanotechnology is an interdisciplinary science that has developed rapidly in recent years. Metallic nanoparticles (NPs) are increasingly utilized in dermatology and cosmetology, because of their unique properties. However, skin exposure to NPs raises concerns regarding their transdermal toxicity. The tight junctions of epithelial cells form the skin barrier, which protects the host against external substances. Recent studies have found that NPs can pass through the skin barrier into deeper layers, indicating that skin exposure is a means for NPs to enter the body. The distribution and interaction of NPs with skin cells may cause toxic side effects. In this review, possible penetration pathways and related toxicity mechanisms are discussed. The limitations of current experimental methods on the penetration and toxic effects of metallic NPs are also described. This review contributes to a better understanding of the risks of topically applied metallic NPs and provides a foundation for future studies. Keywords: metallic nanoparticles, transdermal penetration, toxicity
format	article
author	Wang M Lai X Shao L Li L
author_facet	Wang M Lai X Shao L Li L
author_sort	Wang M
title	Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles
title_short	Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles
title_full	Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles
title_fullStr	Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles
title_full_unstemmed	Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles
title_sort	evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d39a233d9879459fb03f469f7116b57d
work_keys_str_mv	AT wangm evaluationofimmunoresponsesandcytotoxicityfromskinexposuretometallicnanoparticles AT laix evaluationofimmunoresponsesandcytotoxicityfromskinexposuretometallicnanoparticles AT shaol evaluationofimmunoresponsesandcytotoxicityfromskinexposuretometallicnanoparticles AT lil evaluationofimmunoresponsesandcytotoxicityfromskinexposuretometallicnanoparticles
_version_	1718400500156596224

Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles

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